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298-46-4 structure, C15H12N2O
carbamazepine
CAS No.: 298-46-4 Formula: C15H12N2O Molecular Weight: 236.26900
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298-46-4 structure, C15H12N2O

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298-46-4 structure, C15H12N2O

carbamazepine

CAS No.:

298-46-4

 Formula:

C15H12N2O

 Molecular Weight: 236.26900
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Description

Carbamazepine (CBZ), sold under the tradename Tegretol among others, is a medication used primarily in the treatment of epilepsy and neuropathic pain. For seizures it works as well as phenytoin and valproate.[needs update][needs update] It is not effective for absence seizures or myoclonic seizures. It may be used in schizophrenia along with other medications and as a second line agent in bipolar disorder. It is taken two to four times per day. A controlled release formulation is available for which there is tentative evidence showing fewer side effects.[needs update]; Common side effects include nausea and drowsiness. Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion. It should not be used in those with a history of bone marrow problems. Use during pregnancy may cause harm to the baby; however stopping it in pregnant women with seizures is not recommended. Its use during breastfeeding is not recommended. Care should be taken in those with either kidney or liver problems.
Carbamazepine was discovered in 1953 by Swiss chemist Walter Schindler. It was first marketed in 1962. It is available as a generic medication and is not very expensive. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. The wholesale cost in the developing world is between 0.01 and 0.07 USD per dose as of 2014.

Basic Info

Chemical Name

 carbamazepine

Synonyms

5H-Dibenz[b,f]azepine-5-carboxamide; TEGRETOL; Biston; Neurotol; Carbamazepine; Sirtal; Timonil; Carbamazepin; Epitol; Carbelan; Calepsin; 5H-Dibenzo[b,f]azepine-5-carboxamide; Lexin; Expand

CAS No.

 298-46-4

Molecular Formula

 C15H12N2O

Molecular Weight

 236.26900

PSA

 46.33000

LogP

 4.15250

Numbering system

MDL number MFCD00005073

Properties

Appearance & Physical State

 white to off-white powder

Density

 1.266g/cm3

Boiling Point

 411ºC at 760mmHg

Melting Point

 189-192ºC

Flash Point

 202.4ºC

Refractive Index

 1.669

Water Solubility

 pract. insoluble

Stability

 Stable under normal temperatures and pressures.

Storage Condition

 2-8ºC

Vapor Pressure

 5.78E-07mmHg at 25°C

Safety Info

RTECS

 HN8225000

Hazard Class

 6.1(b)

Safety Statements

 S22-S24-S37

HS Code

 2933990090

Packing Group

 III

RIDADR

 3249

Risk Statements

 R22; R42/43

Hazard Codes

 Xn
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Precursor:
5H-dibenzo[b,f]azepine potassium cyanate cyanic acid Iminostilbene N-Carbonyl Chloride trans-10,11-dibromo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide Chlorosulfonyl Isocyanate benzo[b][1]benzazepine-11-carbonitrile sodium cyanate Urea monohydrochloride hydrogen peroxide
Product:
5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide benzo[b][1]benzazepine-11-carbonitrile oxcarbazepine glyoxylic acid carbamazepine-10,11-epoxide 10,11-Dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide Glyoxal anthranilic acid carbamazepine cyclobutyl dimer Oxalic acid
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Compound Synonyms: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 1 2 3 4 5 6 7 8 9

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