anthranilic acid
CAS No.: 118-92-3 Formula: C7H7NO2 Molecular Weight: 137.13600

anthranilic acid

CAS No.: 118-92-3 Formula: C7H7NO2 Molecular Weight: 137.13600
Suppliers: All(0) China Suppliers(0) Price Available(0) Contractor(0)


Anthranilic Acid is is used as an intermediate for production of dyes, pigments, and saccharin. Anthranilic Acid is used in the synthesis of drugs of abuse such as Methaqualone for use as internal standards in quantification and its labelled analogue is used in the quantitative profiling of tryptophan metabolites.


Appearance & Physical State White to pale yellow crystalline powder
Density 1.412
Melting Point 144-148ºC
Flash Point 150ºC
Refractive Index 1.578 (144ºC)
Water Solubility 5.7 g/L (25 ºC)
Stability Stable. Incompatible with strong oxidizing agents.
Storage Condition Store at 0ºC
Vapor Density 4.7 (vs air)
Vapor Pressure 0.000234mmHg at 25°C

Safety Info

RTECS CB2450000
Safety Statements S26-S39
HS Code 2922431000
WGK Germany 2
Risk Statements R36; R37
Hazard Codes Xi
SDS 1.0 Expand

SDS 1.0

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According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017


1.1 GHS Product identifier

Product name anthranilic acid

1.2 Other means of identification

Product number -
Other names 2-amino-benzoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Serious eye damage, Category 1

2.2 GHS label elements, including precautionary statements

Signal word


Hazard statement(s)

H318 Causes serious eye damage

Precautionary statement(s)

P280 Wear protective gloves/protective clothing/eye protection/face protection.


P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P310 Immediately call a POISON CENTER/doctor/…





2.3 Other hazards which do not result in classification


3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
anthranilic acid anthranilic acid 118-92-3 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest.

In case of skin contact

Rinse and then wash skin with water and soap.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give one or two glasses of water to drink. Seek medical attention if you feel unwell.

4.2 Most important symptoms/effects, acute and delayed

SYMPTOMS: Symptoms of exposure to this compound may include nausea, vomiting, acidosis, rash, fever, methemoglobinemia and possibly hepatitis. Other symptoms of exposure include allergic reaction and cyanosis (bluing of skin). Skin contact may cause irritation, itching and dermatitis. It may also cause pruritus. Eye contact may cause irritation. Exposure may cause respiratory irritation, mucous membrane irritation, conjunctivitis and liver inflammation. ACUTE/CHRONIC HAZARDS: This compound is moderately toxic by ingestion. It may be harmful by inhalation or skin absorption. It may cause irritation of the skin and eyes. It may also be absorbed through the skin. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides.

4.3 Indication of immediate medical attention and special treatment needed, if necessary

/First aid for: inhalation exposure-/ fresh air, rest; refer for medical attention; /for skin exposure-/ remove contaminated clothes; rinse and then wash skin with water and soap; /for eye exposure-/ first rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor; /for ingestion-/ rinse mouth; give plenty of water to drink; refer for medical attention. /from table/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Powder, water spray, foam, carbon dioxide. /from table/

5.2 Specific hazards arising from the chemical

This chemical is combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.

6.3 Methods and materials for containment and cleaning up

Remove all ignition sources. Sweep spilled substance into covered containers; if appropriate, moisten first to prevent dusting, then remove to safe place. Do NOT let this chemical enter the environment.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from oxidants.Separated from strong oxidants. /from table/

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state White to pale yellow crystalline powder
Colour White to pale yellow, crystalline powder
Odour no data available
Melting point/ freezing point 144-148ºC
Boiling point or initial boiling point and boiling range Sublimes
Flammability Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 150ºC
Auto-ignition temperature >530°C
Decomposition temperature 200°C
pH no data available
Kinematic viscosity no data available
Solubility In water:5.7 g/L (25 ºC)
Partition coefficient n-octanol/water (log value) log Kow = 1.21
Vapour pressure 0.000234mmHg at 25°C
Density and/or relative density 1.412
Relative vapour density 4.7 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Change on exposure to light, due to photooxidation.

10.3 Possibility of hazardous reactions

Combustible. /from table/Dust explosion possible if in powder or granular form, mixed with air.ANTHRANILIC ACID is incompatible with strong oxidizers.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Reacts with oxidants causing fire hazard. /from table/

10.6 Hazardous decomposition products

On combustion, forms carbon monoxide, nitrogen oxides. /from table/

11.Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available


No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Anthranilic acid (10 ppm) degraded 100% in 2 days using a 1% suspension of Niagara silt loam at 25°C(1). Biodegradation of anthranilic acid was studied using 7 different tests, (inoculum conc, incubation time, chemical conc) result; closed bottle (1 drop sewage/L, 30 days, 2 ppm) 90% BODT; OECD screening (0.05% sewage effluent, 19 days, 20 ppm carbon) 100% DOC; Sturm CO2-evolution (1% sewage, 28 days, 10 ppm carbon) 71% CO2 and 100% DOC removal; French AFNOR (sewage, 42 days, 40 ppm carbon) 93% DOC removal; Japanese MITI (30 mg activated sludge/L, 14 days, 50 ppm carbon) 70% BODT; Zahn-Wellens (1 g activated sludge/L, 14 days, 400 ppm carbon) 97% DOC after 1 day; OECD coupled units (2500 mg sewage/L, 12 ppm carbon) 103%DOC removal(2). Warburg activated sludge screening tests gave results of 96% BODT in 0.6 days after 20 days of acclimation(3), 17% BODT after 8 days(4) and 50% BODT in 0.5 days after 23 hours acclimation(5). Anthranilic acid degraded 81% in a 5 day BOD test using sewage at 20°C(6). Anthranilic acid degraded 97.5% by COD removal in 5 days after 20 days acclimation of activated sludge(7). A 5 day BOD test gave 62.7% biodegradation of anthranilic acid in Songhua River water collected from Jilin Province, China(8). Anthranilic acid degraded 104 and 127% in 8 weeks after a 1 week lag time in a 10% sludge(9).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for anthranilic acid(SRC), using a log Kow of 1.21(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of anthranilic acid is estimated as 110(SRC), using a log Kow of 1.21(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that anthranilic acid is expected to have high mobility in soil. The pKa of anthranilic acid is 2.14(4), indicating that this compound will primarily exist in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods


The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: no data available IMDG: no data available IATA: no data available

14.2 UN Proper Shipping Name

ADR/RID: no data available
IMDG: no data available
IATA: no data available

14.3 Transport hazard class(es)

ADR/RID: no data available IMDG: no data available IATA: no data available

14.4 Packing group, if applicable

ADR/RID: no data available IMDG: no data available IATA: no data available

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
anthranilic acid anthranilic acid 118-92-3 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 15, 2017
Revision Date Aug 15, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%


  • IPCS - The International Chemical Safety Cards (ICSC), website:
  • HSDB - Hazardous Substances Data Bank, website:
  • IARC - International Agency for Research on Cancer, website:
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
  • CAMEO Chemicals, website:
  • ChemIDplus, website:
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:
  • Germany GESTIS-database on hazard substance, website:
  • ECHA - European Chemicals Agency, website:

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS Expand
1H NMR : 90 MHz in DMSO-d6Expand

NMR Spectrum 1H NMR : 90 MHz in DMSO-d6


C7 H7 N O2 0.042 g : 0.5 ml DMSO-d6
anthranilic acid

Assign. Shift(ppm)
A 8.4
B 7.72
C 7.23
D 6.761
E 6.524
F 3.6

J(B,C)=1.6HZ. J(B,E)=8.0HZ. J(C,D)=8.3HZ. J(D,E)=1.3HZ.

IR : CCl4 solutionExpand
Mass spectrum (electron ionization)Expand
UV/Visible spectrumExpand

GC Analysis

Total 4 Documents >>
Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
Capillary VF-5MS - 1413.1 custom temperature program
Capillary HP-5 MS - 1416. temperature ramp
Capillary DB-Wax - 2997. temperature ramp
Capillary DB-Wax - 3021. temperature ramp
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