carbamazepine
CAS No.: 298-46-4 Formula: C15H12N2O Molecular Weight: 236.26900
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carbamazepine

CAS No.: 298-46-4 Formula: C15H12N2O Molecular Weight: 236.26900
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Description

Carbamazepine (CBZ), sold under the tradename Tegretol among others, is a medication used primarily in the treatment of epilepsy and neuropathic pain. For seizures it works as well as phenytoin and valproate.[needs update][needs update] It is not effective for absence seizures or myoclonic seizures. It may be used in schizophrenia along with other medications and as a second line agent in bipolar disorder. It is taken two to four times per day. A controlled release formulation is available for which there is tentative evidence showing fewer side effects.[needs update]; Common side effects include nausea and drowsiness. Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion. It should not be used in those with a history of bone marrow problems. Use during pregnancy may cause harm to the baby; however stopping it in pregnant women with seizures is not recommended. Its use during breastfeeding is not recommended. Care should be taken in those with either kidney or liver problems.
Carbamazepine was discovered in 1953 by Swiss chemist Walter Schindler. It was first marketed in 1962. It is available as a generic medication and is not very expensive. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. The wholesale cost in the developing world is between 0.01 and 0.07 USD per dose as of 2014.

Basic Info

Chemical Name carbamazepine
Synonyms

5H-Dibenz[b,f]azepine-5-carboxamide; TEGRETOL; Biston; Neurotol; Carbamazepine; Sirtal; Timonil; Carbamazepin; Epitol; Carbelan; Calepsin; 5H-Dibenzo[b,f]azepine-5-carboxamide; Lexin; Expand

CAS No. 298-46-4
Molecular Formula C15H12N2O
Molecular Weight 236.26900
PSA 46.33000
LogP 4.15250

Numbering system

MDL number MFCD00005073

Properties

Appearance & Physical State white to off-white powder
Density 1.266g/cm3
Boiling Point 411ºC at 760mmHg
Melting Point 189-192ºC
Flash Point 202.4ºC
Refractive Index 1.669
Water Solubility pract. insoluble
Stability Stable under normal temperatures and pressures.
Storage Condition 2-8ºC
Vapor Pressure 5.78E-07mmHg at 25°C

Safety Info

RTECS HN8225000
Hazard Class 6.1(b)
Safety Statements S22-S24-S37
HS Code 2933990090
Packing Group III
RIDADR 3249
Risk Statements R22; R42/43
Hazard Codes Xn
1H NMR : 400 MHz in CDCl3Expand

NMR Spectrum 1H NMR : 400 MHz in CDCl3

Collapse

C15 H12 N2 O 0.038 g : 0.5 ml CDCl3
5H-dibenz(b,f)azepine-5-carboxamide

Assign. Shift(ppm)
A 7.444
B 7.398
C 7.339
D 7.300
E 6.908
F 5.0

IR : KBr discExpand
Mass spectrum (electron ionization)Expand
UV/Visible spectrumExpand
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