4-hydroxycyclophosphamide

Edit: 4-hydroxycyclophosphamide

CAS No.:
40277-05-2
Formula:
C7H15Cl2N2O3P
Molecular Weight: 277.08500

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Overview
Description
Basic Info
Numbering system
Properties
Safety Info
Synthesis Route
Downstream Product

Description

4-Hydroxycyclophosphamide is in the class of oxazaphosphorine compounds, and is the main, active metabolite of cyclophosphamide and of mafosfamide after they partially metabolized by cytochrome P450. It is then partially tautomerized into aldophosphamide, which, in turn, easily enters live cells and then is partially detoxified into inactive carboxycyclophosphamide by the enzyme ALDH, but partially is hydrolyzed by another cell's enzyme phosphatase to the two directly cytotoxic metabolites - phosphoramide mustard and acrolein.

Basic Info

Chemical Name	4-hydroxycyclophosphamide
Synonyms	4-Hydroperoxydechlorocyclophosphamide; 4-Hydroxycyclophosphamid; 4-OH cyclophosphamide; 4-Hydroxycyclophosphamide; 2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ<sup>5</sup>-oxazaphosphinan-4-ol;
CAS No.	40277-05-2
Molecular Formula	C7H15Cl2N2O3P
Molecular Weight	277.08500
PSA	71.61000
LogP	1.53120

Numbering system

MDL number	MFCD00869529

Properties

Density	1.42g/cm3
Boiling Point	387.1ºC at 760 mmHg
Flash Point	187.9ºC
Refractive Index	1.527

Safety Info

HS Code	2934999090

Synthesis Route

Total 3 Documents >>

: 50-18-0
cyclophosphamide

: 40277-05-2
4-hydroxycyclophosphamide

: 51274-71-6
4-[[2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ5-oxazaphosphinan-4-yl]peroxy]-N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine

Detail>>

Downstream Product

Total 2 Documents >>

: 65882-95-3
sodium,5-(2,2-dimethylpropyl)-5-methyl-4-oxo-1,3-oxazol-2-olate

: 51274-71-6
4-[[2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ5-oxazaphosphinan-4-yl]peroxy]-N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine

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40277-05-2

C7H15Cl2N2O3P

Description

Basic Info

Chemical Name

Synonyms

CAS No.

Molecular Formula

Molecular Weight

PSA

LogP

Numbering system

Properties

Density

Boiling Point

Flash Point

Refractive Index

Safety Info

HS Code

Synthesis Route

Downstream Product

Hangzhou J&H Chemical Co., Ltd.

Henan Coreychem Co.,Ltd

Ibookbio

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