amiloride hydrochloride

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: amiloride hydrochloride
CAS No.: 2016-88-8 Formula: C6H9Cl2N7O Molecular Weight: 266.08800
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CAS No.:
2016-88-8
Formula:
C6H9Cl2N7O
Molecular Weight: 266.08800

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Overview
Description
Basic Info
Numbering system
Properties
Safety Info

Description

Amiloride is a potassium-sparing diuretic, first approved for use in 1967 (then known as MK 870), used in the management of hypertension and congestive heart failure. Amiloride was also tested as treatment of cystic fibrosis, but it was revealed inefficient in vivo due to its short time of action, therefore longer-acting epithelial sodium channel (ENaC) inhibitors may prove more effective, e.g. benzamil.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Basic Info

Chemical Name	amiloride hydrochloride
Synonyms	N-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride; GUANAMPRAZINE; Arumil; amiprazidine; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride; AMipraMidine; HCL AMILORIDE HCL; AMILORIDE HCL; N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate; AMIPRAMIZIDE; 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide Hydrochloride Hydrate; Amiloridhydrochlorid; amiloridechloride; Amiloride (hydrochloride); AMIPRAMIDIN; AMipraMizi; Amiloride hydrochloride; Expand
CAS No.	2016-88-8
Molecular Formula	C6H9Cl2N7O
Molecular Weight	266.08800
PSA	156.79000
LogP	2.07300

Numbering system

EINECS number	217-958-2
MDL number	MFCD00058197
PubChem number	24277817
RTECS number	UQ2275500

Properties

Appearance & Physical State	Light yellow solid.
Density	2.11 g/cm3
Boiling Point	628.1ºC at 760 mmHg
Melting Point	293-294ºC
Flash Point	333.7ºC
Storage Condition	Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Vapor Pressure	1.08E-15mmHg at 25°C

Safety Info

RTECS	UQ2275500
Hazard Class	6.1(a)
Safety Statements	S36-S45
HS Code	29339980
WGK Germany	3
Packing Group	II
RIDADR	UN 2811
Risk Statements	R25
Hazard Codes	T

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