indocyanine green

Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. It has a peak spectral absorption at about 800nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than fluorescein angiography. ICG binds tightly to plasma proteins and becomes confined to the vascular system. ICG has a half-life of 150 to 180 seconds and is removed from circulation exclusively by the liver to bile juice.
ICG is a fluorescent dye which is used in medicine as an indicator substance (e.g. for photometric hepatic function diagnostics and fluorescence angiography) in cardiac, circulatory, hepatic and ophthalmic conditions. It is administered intravenously and, depending on liver performance, is eliminated from the body with a half life of approx. 3–4 minutes. ICG sodium salt is normally available in powder form and can be dissolved in various solvents; 5% (<5% depending on batch) sodium iodide is usually added to ensure better solubility. The sterile lyophilisate of a water-ICG solution is approved many European countries and the United States under the names ICG-Pulsion and IC-Green as a diagnostic for intravenous use.

Chemical Name	indocyanine green
Synonyms	IR-125,laser grade; Indocyanine Green; Foxgreen,IC Green,Indocyanine green; Sodium 2-(7-(3,3-dimethyl-1-(4-sulfonatobutyl)benz(e)indolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolinium; Cardiogreen,Foxgreen,IC Green; Cardio-green; Expand
CAS No.	3599-32-4
Molecular Formula	C43H47N2NaO6S2
Molecular Weight	774.96300
PSA	137.41000
LogP	10.55570

UNII	IX6J1063HV

Appearance & Physical State	GREEN TO GREEN WITH A BROWN CAST POWDER
Boiling Point	157ºC
Melting Point	235ºC
Water Solubility	slightly soluble
Stability	Stable under normal temperatures and pressures.
Storage Condition	Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

RTECS	DE3150000
Safety Statements	S26-S37/39
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xi