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N-Benzyloxycarbonyl-D-proline
CAS No.: 6404-31-5 Formula: C13H15NO4 Molecular Weight: 249.26200Search Suppliers
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N-Benzyloxycarbonyl-D-proline
CAS No.:6404-31-5
Formula:C13H15NO4
Molecular Weight: 249.26200
Description
N-(Benzyloxycarbonyl)-D-proline is an an N-Cbz-protected form of D-proline. It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.
Basic Info
Chemical Name |
N-Benzyloxycarbonyl-D-proline |
|---|---|
Synonyms |
|
CAS No. |
6404-31-5 |
Molecular Formula |
C13H15NO4 |
Molecular Weight |
249.26200 |
PSA |
66.84000 |
LogP |
1.81010 |
Numbering system
| EINECS number | 229-021-5 |
|---|
Properties
Appearance & Physical State |
white to off-white crystalline powder |
|---|---|
Density |
1.309 g/cm3 |
Boiling Point |
75 - 77ºC |
Melting Point |
75-79ºC |
Flash Point |
215.3ºC |
Refractive Index |
40 ° (C=2, EtOH) |
Storage Condition |
Store at RT. |
Safety Info
WGK Germany |
3 |
|---|---|
Hazard Codes |
Xi |
Synthesis Route
Total 13 Documents >>
Precursor
Total 14 Documents >>
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- Precursor:
- Benzyl chloroformate (R)-methyl 4-azido-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butanoate 1-Chloroethyl benzyl carbonate N-(Benzyloxycarbonyloxy)succinimide (2S)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid (R)-4-azido-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butanal methyl 2,3-dideoxy-5,6-O-isopropylidene-4-O-p-tolylsulfonyl-D-erythro-hexonate proline D-proline
- Product:
- benzyl (2R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate benzyl (2R)-2-carbamoylpyrrolidine-1-carboxylate (R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole 1-[5-bromo-3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]indol-1-yl]ethanone (R)-1-Cbz-2-Cyano-Pyrrolidine pyrrolidin-2-ylmethylamine (R)-Benzyl 2-(5-bromo-1H-indole-3-carbonyl)-pyrrolidine-1-carboxylate (2R)-pyrrolidine-2-carboxamide eletriptan D-proline
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