Simagchem Corp.

Uses 1. Application in healthcare industry

Collagen is mainly used as scaffolds, skin and bones in tissue engineering. With the application of collagen in tissue engineering, the study of biological membrane also becomes more extensive such as vascular membrane, ligaments and heart valves.

Collagen has good biocompatibility and biodegradable security. It can be degraded and absorbed, and have a good adhesion force thus having a unique skin repair function which can be used for skin transplant after modification. Collagen can form the skeleton of the extracellular matrix and is an important component of cells. It plays a role of anchoring and supporting the cells, and providing the appropriate microenvironment for cell proliferation and growth, also providing a good supply of nutrients. Thus whether as the backbone of the new organization before being absorbed, or being assimilated into the host to become part of it, the collagen always has good interaction with the matrix surrounding them which exhibits the coordination of interaction with each other. This will boost the normal proliferation and repairmen of epithelial cells, thus boosting the healing wound healing of the wound. In this case, it is used for burns and trauma repair, treatment and care, reducing and alleviating the degree of burns. Collagen biological dressing has two advantages: First, the preparation method is simple, easy for sterilization, easy for process; the second is having good adhesion, suitable for the formation of granulation tissue and epithelial cells; can reduce the contracture and antigenic response of wounds, having a good hemostatic effect and easy to absorb tissue exudates.

Because of its unique properties, collagen protein can also be used to treat ophthalmic diseases. Collagen can promote cell growth and the repair of corneal epithelial cell damage, and can also be dissolved in tears. It also has the ability to introduce epithelia cells into the defect area. At the same time, its degraded products can be taken advantage by new cells for new collagen synthesis, which plays the role of connecting different cells. Thus, it is widely applied in the treatment of eye diseases. Collagen can also be used as the carrier for ocular administration, with the function of increasing drug concentration, prolonging drug action time, and reducing the systemic toxicity of the drug, which has broad prospects for development.

In clinical medicine, collagen has also been widely used for cosmetic and orthopedic treatment, for treatment of periodontal diseases, for hard tissue repair, for nerve repair and regeneration, as the wrapping materials of periodontal nerve repair, as artificial organs, as pacemakers and the filling materials of human organs.

2. The application in cosmetics

Collagen can be extracted from animal skin which also contains some proteoglycans like hyaluronic acid, chondroitin sulfate in addition to collagen, which all belongs to the natural moisturizing factor as important materials for maintaining skin moisture. Moreover it also has the role of preventing the conversion of tyrosine into melanin in the skin. Collagen, similar with the collagen structure in the skin and also the stratum corneum, which promotes the proliferation and repair of epithelial cell and replenishes amino acids and other nutrients, improves the living environment of skin cells, promotes the metabolism of skin and enhance circulation, fill and repair the damaged and aging skin, and also has a good compatibility, affinity and permeability with the skin. It can be fully absorbed by the skin and make the skin plump, stretch the wrinkles while being able to increase the density of the skin and resulting in tension. Therefore, collagen has a natural effect of moisturizing, whitening, eliminating freckle and wrinkle, and thus be widely used in the cosmetics industry. Currently on the market, many selling cosmetics such as masks, eye creams, skin creams contain collagen.

3. Application in Food Industry

There are two aspects of the application of collagen in food industry: its function and nutrition, respectively. Collagen peptides can be directly taken as a functional food alone, such as chewable tablets, and protein powders or enteral nutrition agents desired for athletes. Having foods rich in collagen can not only effectively delay the aging of body, strengthening the gluten and bone, enhancing physical fitness, but also lose the weight and blood pressure and have other health effects like replenishing calcium. Treating collagen with specific enzyme can break the intermolecular hydrogen bonds and further disrupting the original compact super-coiled structure. The resulting structure is more loosely-formed small molecules whose addition to the meat products can improve the connective tissue, increase the protein content, and have good taste and nutritious. The hydrolysis products of collagen can be used as frozen food modifier for using as thickening agent and have a low melting point, easy to be dissolved immediately after entrance into mouth. Therefore, collagen is widely used in jelly, sour cheese, ham, canned food, and bread. In addition, using the film-forming property can make collagen be the membrane materials for solidified and the labels of meat. Collagen can also be used as food adhesive for synthesizing film and as protective layer of food like meat and fish which has antioxidant activity while maintaining the bright color of meat.

4. Applications in other fields

With the continuous studies of collagen, there are increasing cases and promising prospects that collagen are applied in other fields. For example, extracting the collagen rich in the residual waste of tanning process can make collagen be the protein resources for feeding animal which realizes resource utilization. After the denaturation treatment of collagen, we can improve its textile properties and apply to the textile industry. In recent years, there are more and more cases that collagen has been applied to light industry such as paper industry, leather industry, and daily chemical industry. With the continuous development and progress of research techniques, it is clear that collagen will have broader application.

Chemical properties Yellowish flakes freeze-dried substance; It is the main component of skin, connective tissue, bone and teeth. Different sources of collagen have different types, but they all contain three α chain, and are arranged into three-helical conformation. The slight difference in primary structure results in the formation of different types of collagen. The denatured collagen is referred as gelatin.

Uses Surgical suture fibers; as the substrate for measuring collagen.

Synthetic method Use bovine tendon as the raw materials. Extract it with disodium hydrogen phosphate solution and KCl solution. Wash the residue, dehydrate and dry to obtain the finished product.

Chemical Properties type V

Uses for collagenase binding

Uses inhibit carcinogenesis