N-Aminoethylpiperazine
CAS No.: 140-31-8 Formula: C6H15N3 Molecular Weight: 129.20300
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N-Aminoethylpiperazine

CAS No.: 140-31-8 Formula: C6H15N3 Molecular Weight: 129.20300
Suppliers: All (44) China Suppliers (44) Price Available (11) Contractor(0)

Description

Aminoethylpiperazine is a derivative of piperazine. This ethyleneamine contains one primary, secondary and tertiary nitrogen atom. It is a corrosive liquid and can cause second or third degree burns. Aminoethylpiperazine can also cause pulmonary edema as a result of inhalation. Uses include inhibition of corrosion, epoxy curing, surface activation, and as an asphalt additive.

Basic Info

Chemical Name N-Aminoethylpiperazine
Synonyms

2-(Piperazin-1-yl)ethanamine; 1-(2-Aminoethyl)piperazine; 2-piperazin-1-ylethanamine; 1-Piperazineethanamine; N-(2-Aminoethyl)piperazine;

CAS No. 140-31-8
Molecular Formula C6H15N3
Molecular Weight 129.20300
PSA 41.29000
LogP -0.18270

Numbering system

MDL number MFCD00005971
EINECS number 205-411-0
BRN number 104363
RTECS number TK8050000
PubChem number 24890984

Properties

Appearance & Physical State clear liquid
Density 0.985
Boiling Point 218-222ºC
Melting Point -19ºC
Flash Point 93ºC
Refractive Index 1.499-1.501
Water Solubility soluble
Stability Stable. Flammable. Incompatible with acids, acid anhydrides, acid chlorides, strong oxidizing agents, chloroformates.
Storage Condition Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area. Store protected from moisture.
Vapor Density 4.4 (vs air)
Vapor Pressure 0.05 mm Hg ( 20 °C)

Safety Info

RTECS TK8050000
Hazard Class 8
Safety Statements S26-S36/37/39-S45-S61
HS Code 2933599090
Packing Group III
WGK Germany 2
RIDADR UN 2815
Risk Statements R21/22; R34; R43; R52/53
Hazard Codes C
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SDS 1.0

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name N-Aminoethylpiperazine

1.2 Other means of identification

Product number -
Other names 2-(Piperazin-1-yl)ethanamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Adhesives and sealant chemicals,Functional fluids (closed systems),Intermediates,Ion exchange agents,Paint additives and coating additives not described by other categories
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Acute toxicity - Dermal, Category 4

Skin corrosion, Category 1B

Skin sensitization, Category 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H302 Harmful if swallowed

H312 Harmful in contact with skin

H314 Causes severe skin burns and eye damage

H317 May cause an allergic skin reaction

H412 Harmful to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P273 Avoid release to the environment.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P310 Immediately call a POISON CENTER/doctor/…

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
N-Aminoethylpiperazine N-Aminoethylpiperazine 140-31-8 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

INHALATION: Burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. EYES AND SKIN: Extremely destructive to mucous membranes, upper respiratory tract, eyes and skin. Causes burns on short contact. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Solid streams of water may be ineffective. Use "alcohol" foam, dry chemical, or carbon dioxide.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Toxic fumes of NO x (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Do not let product enter drains. Discharge into the environment must be avoided. Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state clear liquid
Colour Light-colored liquid
Odour no data available
Melting point/ freezing point -19°C(lit.)
Boiling point or initial boiling point and boiling range 222°C(lit.)
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 93°C(lit.)
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:soluble
Partition coefficient n-octanol/water (log value) log Kow = -1.57 (est)
Vapour pressure 0.05 mm Hg ( 20 °C)
Density and/or relative density 0.985
Relative vapour density 4.4 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

N-AMINOETHYLPIPERAZINE neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Materials to avoid: oxidizing agents

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic fumes of /nitric oxides/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 2140 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnow, age 31 days, mean length 21.0 mm, mean weight 0.147 g); Conditions: flow through, 25.1°C, pH 7.66, hardness 37.8 mg/L CaCO3, alkalinity 92.0 mg/L CaCO3, dissolved oxygen 6.1 mg/L; Concentration: 2190 mg/L for 96 hr (95% confidence limit: 1950-2460 mg/L) /97% purity
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: N-(2-Aminoethyl)piperazine, present at 100 mg/L, reached 0-1% of its theoretical BOD (one test result resulted in -1% theoretical BOD indicating toxicity) in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for N-(2-aminoethyl)piperazine(SRC), using an estimated log Kow of -1.6(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc of N-(2-aminoethyl)piperazine can be estimated to be 43(SRC). According to a classification scheme(2), this estimated Koc value suggests that N-(2-aminoethyl)piperazine is expected to have very high mobility in soil. However, N-(2-aminoethyl)piperazine will exist primarily as a cation in the environment, and cations are expected to adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(3), suggesting that mobility may be much lower in some soils(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN2815 IMDG: UN2815 IATA: UN2815

14.2 UN Proper Shipping Name

ADR/RID: N-AMINOETHYLPIPERAZINE
IMDG: N-AMINOETHYLPIPERAZINE
IATA: N-AMINOETHYLPIPERAZINE

14.3 Transport hazard class(es)

ADR/RID: 8 IMDG: 8 IATA: 8

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
N-Aminoethylpiperazine N-Aminoethylpiperazine 140-31-8 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS Expand
1H NMR : 400 MHz in CDCl3Expand

NMR Spectrum 1H NMR : 400 MHz in CDCl3

Collapse

C6 H15 N3 0.05 ml : 0.5 ml CDCl3
1-(2-aminoethyl)piperazine

Assign. Shift(ppm)
A 2.879
B 2.782
C 2.40
D 2.40
E 1.32

IR : CCl4 solutionExpand
Mass spectrum (electron ionization)Expand
Raman : 4880 A,200 M,liquidExpand

GC Analysis

Total 9 Documents >>
Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
Packed PMS-100 130. 1150. isothermal
Packed PMS-100 150. 1186. isothermal
Packed PMS-100 180. 1198. isothermal
Packed PEG-2000 150. 1795. isothermal
Packed PEG-2000 152. 1806. isothermal
Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
Administration onto the skin Open irritation test Rodent - rabbit 100 ug/24H -
Administration onto the skin Standard Draize test Rodent - rabbit 5 mg/24H -
Administration into the eye Standard Draize test Rodent - rabbit 20 mg/24H -
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