glutaraldehyde
CAS No.: 111-30-8 Formula: C5H8O2 Molecular Weight: 100.11600
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glutaraldehyde

CAS No.: 111-30-8 Formula: C5H8O2 Molecular Weight: 100.11600
Suppliers: All (108) China Suppliers (108) Price Available (20) Contractor (10)

Description

Glutaraldehyde is an organic compound with the formula CH2(CH2CHO)2. A pungent colorless oily liquid, glutaraldehyde is used as a sterilisation agent and preservative. It is mainly available as an aqueous solution, and in these solutions the aldehyde groups are hydrated.

Numbering system

EINECS number 203-856-5
MDL number MFCD00007025
BRN number 605390
RTECS number MA2450000
PubChem number 24895235

Properties

Appearance & Physical State Clear to yellowish liquid
Density 1.06
Boiling Point 100ºC
Melting Point -5ºC
Flash Point 71ºC
Refractive Index 1.373
Water Solubility miscible
Storage Condition 2-8ºC
Vapor Pressure 0.583mmHg at 25°C

Safety Info

RTECS MA2450000
Hazard Class 8
Safety Statements S26-S36/37/39-S45
HS Code 2912190090
Packing Group II
WGK Germany 3
RIDADR UN 2810
Risk Statements R22; R23; R34; R42/43
Hazard Codes T
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name glutaraldehyde

1.2 Other means of identification

Product number -
Other names pentane-1,3,5-tricarboxylic acid trimethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Skin corrosion, Category 1B

Skin sensitization, Category 1A

Acute toxicity - Inhalation, Category 2

Specific target organ toxicity – single exposure, Category 3

Respiratory sensitization, Category 1

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H410 Very toxic to aquatic life with long lasting effects

H301 Toxic if swallowed

H314 Causes severe skin burns and eye damage

H317 May cause an allergic skin reaction

H330 Fatal if inhaled

H335 May cause respiratory irritation

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

P273 Avoid release to the environment.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P310 Immediately call a POISON CENTER/doctor/…

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P320 Specific treatment is urgent (see ... on this label).

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/...

P391 Collect spillage.

Storage

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
glutaraldehyde glutaraldehyde 111-30-8 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Contact with liquid causes severe irritation of eyes and irritation of skin. Chemical readily penetrates skin in harmful amounts. Ingestion causes irritation of mouth and stomach. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Aldehydes and Related Compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

Literature sources indicate that this chemical is nonflammable.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

6.3 Methods and materials for containment and cleaning up

Accidental release measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from food and feedstuffs.Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: -20°C. Store under inert gas. Air sensitive.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: Ceiling value: 0.2 ppm (0.8 mg/cu m).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Clear to yellowish liquid
Colour Colorless liquid
Odour Pungent odor
Melting point/ freezing point 255°C(lit.)
Boiling point or initial boiling point and boiling range 97°C/24mmHg(lit.)
Flammability Noncombustible LiquidNot combustible.
Lower and upper explosion limit / flammability limit no data available
Flash point 51°C(lit.)
Auto-ignition temperature 225°C
Decomposition temperature 187-189°C
pH Mildly acidic (50% solution)
Kinematic viscosity no data available
Solubility In water:miscible
Partition coefficient n-octanol/water (log value) log Kow = -0.33
Vapour pressure 0.583mmHg at 25°C
Density and/or relative density 1.06
Relative vapour density 3.4 (Air = 1)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

NonflammableGLUTARALDEHYDE may discolor on exposure to air. It polymerizes on heating. This chemical is incompatible with strong oxidizing agents. It polymerizes in the presence of water.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Incompatible materials: Strong bases, strong oxidizing agents, strong acids.

10.6 Hazardous decomposition products

When heated to decomposition it emits acrid smoke and irritating fumes.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 134 mg/kg
  • Inhalation: LC50 Rat inhalation 5000 ppm/4 hr exposure
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

A4; Not classifiable as a human carcinogen. /Glutaraldehyde/

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill sunfish); Concentration: 22.6 ppm for 96 hr /Conditions of bioassay not specified in source examined/ /50% glutaraldehyde
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, static; Concentration: 14600 ug/L for 48 hr (11000-18000 ug/L); Effect: intoxication, immobilization /50% purity
  • Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green Algae); Conditions: freshwater, static; Concentration: 310 ug/L for 96 hr (90-1040 ug/L); Effect: population, abundance /50.7% purity
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Glutaraldehyde, present at 100 mg/L, reached 59% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Using OECD Guideline 301C (Ready biodegradability: Modified MITI Test (I)), glutaraldehyde reached 74% of its theoretical BOD in 28 days and 80% DOC in 15 days with classified the compound as readily biodegradable(2). Glutaraldehyde was found to be readily biodegradable using OECD Guideline 301D (Closed Bottle Test)(2). In a DOC die-away test, glutaradehyde, present at 25 mg/L, showed 83% degradation in 5 days using a sewage inoculum(3). Glutaraldehyde, present at 8.3 mg/L, degraded 60% in 28 days using sewage inoculum in a CO2 evolution test(3). In a closed bottle test, glutaraldehyde present at 2.0 mg/L, degraded 64% in 28 days using a Polyseed inoculum(3). A higher biodegradability with a short lag time was observed when the glutaraldehyde concentrations in the test systems were low (<2 mg/L) than when the concentrations were high (>8 mg/L). Since bacterial inhibition for glutaraldehyde occurs at about 5 mg/L, the lower biodegradation rates observed in studies where high concentrations of glutaraldehyde were used were likely due to inhibition of the inoculum(3). In a closed bottle test using seawater as inoculum, glutaraldehyde showed 73% degradation in 28 days(3). The major metabolite of glutaraldehyde produced by microbes in an aerobic sediment-river water system was carbon dioxide, with glutaric acid formed as an intermediate in the water phase(3). The calculated pseudo-first-order half-life of glutaraldehyde catabolism in water (based on the loss of the parent compound) under aerobic conditions was 10.6 hours(3). A soil degradation study using a loamy sand soil and initial glutaraldehyde concentration of 10 ppm observed a pseudo-first order biodegradation half-life of 1.7 days due primarily to soil microorganisms(4).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated for glutaraldehyde(SRC), using a log Kow of -0.33(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Aqueous solutions of [14C] glutaraldehyde in 0.01 M calcium chloride were prepared at concentrations of 0.51, 1.0, 2.5, 5.0, and 10.3 g/L and used to determine the adsorption/desorption characteristics of glutaraldehyde in various soil types according to FIFRA 163-1 guidelines(1). Measured Koc values were 210, 500, 340, 460, and 120 in sandy loam, silty clay loam, silt loam, loamy sand, and sediment, respectively(1). Batch adsorption studies determined Koc values of 22.2, 18.9 and 5.1 in New York loam, Nebraska silt loam and Highview clay loam soils respectively(3). According to a classification scheme(2), these Koc values suggest that glutaraldehyde is expected to have very high to moderate mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN2927 IMDG: UN2927 IATA: UN2927

14.2 UN Proper Shipping Name

ADR/RID: TOXIC LIQUID, CORROSIVE, ORGANIC, N.O.S.
IMDG: TOXIC LIQUID, CORROSIVE, ORGANIC, N.O.S.
IATA: TOXIC LIQUID, CORROSIVE, ORGANIC, N.O.S.

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
glutaraldehyde glutaraldehyde 111-30-8 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS Expand
1H NMR : PredictExpand

NMR Spectrum 1H NMR : Predict

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Mass spectrum (electron ionization)Expand
Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
Administration onto the skin Standard Draize test Human 6 mg/3D (Intermittent) -
Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 134 mg/kg 1.Details of toxic effects not reported other than lethal dose value
Inhalation LC50 - Lethal concentration, 50 percent kill Rodent - rat 480 mg/m3/4H 1.Details of toxic effects not reported other than lethal dose value
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