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UDP-α-D-N-ACETYLGLUCOSAMINE, DISODIUM SALT
CAS No.: 91183-98-1 Formula: C17H25N3Na2O17P2 Molecular Weight: 651.31700
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UDP-α-D-N-ACETYLGLUCOSAMINE, DISODIUM SALT

CAS No.: 91183-98-1 Formula: C17H25N3Na2O17P2 Molecular Weight: 651.31700
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Description

Uridine diphosphate N-acetylglucosamine or UDP-GlcNAc is a nucleotide sugar and a coenzyme in metabolism. It is used by glycosyltransferases to transfer N-acetylglucosamine residues to substrates. D-Glucosamine is made naturally in the form of glucosamine-6-phosphate, and is the biochemical precursor of all nitrogen-containing sugars. To be specific, glucosamine-6-phosphate is synthesized from fructose 6-phosphate and glutamine as the first step of the hexosamine biosynthesis pathway. The end-product of this pathway is UDP-GlcNAc, which is then used for making glycosaminoglycans, proteoglycans, and glycolipids.
UDP-GlcNAc is extensively involved in intracellular signaling as a substrate for O-linked N-acetylglucosamine transferases (OGTs) in a wide range of species. It is also involved in nuclear pore formation and nuclear signalling. OGTs and OG-ases play an important role in the structure of the cytoskeleton. In mammals, there is enrichment of OGT transcripts in the pancreas beta-cells, and UDP-GlcNAc is thought to be part of the glucose sensing mechanism. There is also evidence that it plays a part in insulin sensitivity in other cells. In plants, it is involved in the control of gibberellin production.
Clostridium novyi type A alpha-toxin is an O-linked N-actetylglucosamine transferase acting on Rho proteins and causing the collapse of the cytoskeleton.

Numbering system

EINECS number 293-820-5

Properties

Appearance & Physical State WHITE POWDER
Storage Condition -20ºC

Safety Info

Safety Statements S22; S26; S36
Risk Statements R36/37/38
Hazard Codes Xi
Hazard Declaration H315; H319; H335
Signal Word Warning
Symbol GHS07
Caution Statement P261; P305 + P351 + P338
Predict 1H proton NMRExpand

NMR Spectrum Predict 1H proton NMR

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