Diethyl ether
CAS No.: 60-29-7 Formula: C4H10O Molecular Weight: 74.12160

Diethyl ether

CAS No.: 60-29-7 Formula: C4H10O Molecular Weight: 74.12160
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Basic Info

Chemical Name Diethyl ether
Synonyms

Ethane, 1,1‘-oxybis-;

CAS No. 60-29-7
Molecular Formula C4H10O
Molecular Weight 74.12160
PSA 9.23000
LogP 1.04280

Properties

Appearance & Physical State Clear liquid
Density 0.714
Boiling Point 34.6ºC
Melting Point -116ºC
Freezing Point -116.3℃
Flash Point -45ºC
Refractive Index 1.351-1.353
Water Solubility 69 g/L (20 ºC)
Stability Stable, but light-sensitive, sensitive to air. May contain BHT (2,6-di-tert-butyl-4-methylphenol) as a stabilizer. Substances to be avoided include zinc, halogens, halogen-halogen compounds, nonmetals, nonmetallic oxyhalides, strong oxidizing agents, chrom
Storage Condition Store at RT.
Vapor Density 2.6 (vs air)
Vapor Pressure 28.69 psi ( 55 °C)

Safety Info

RTECS KI5775000
Hazard Class 3
Safety Statements S16-S29-S33-S9
HS Code 2909110000
Packing Group I
WGK Germany 1
RIDADR UN 1155 3/PG 1
Risk Statements R12; R19; R22; R66; R67
Hazard Codes F+; Xn
Caution Statement P210; P301 + P312 + P330; P370 + P378; P403 + P235
Symbol GHS02, GHS07
Signal Word Danger
Supplemental Hazard Statements May form explosive peroxides; Repeated exposure may cause skin dryness or cracking.
Hazard Declaration H224; H302; H336
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SDS 1.0

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Diethyl ether

1.2 Other means of identification

Product number -
Other names Ethane, 1,1‘-oxybis-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food Additives: EXTRACTION_SOLVENT
Uses advised against no data available

1.4 Supplier's details

Company XiXisys.com
Address XiXisys.com
Telephone XiXisys.com
Fax XiXisys.com

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 1

Acute toxicity - Oral, Category 4

Specific target organ toxicity – single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H224 Extremely flammable liquid and vapour

H302 Harmful if swallowed

H336 May cause drowsiness or dizziness

Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

Response

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P312 Call a POISON CENTER/doctor/…if you feel unwell.

Storage

P403+P235 Store in a well-ventilated place. Keep cool.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Diethyl ether Diethyl ether 60-29-7 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Vapor inhalation may cause headache, nausea, vomiting, and loss of consciousness. Contact with eyes will be irritating. Skin contact from clothing wet with the chemical may cause burns. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

INHALATION: Cough. Sore throat. Drowsiness. Vomiting. Headache. Labored breathing. Unconsciousness. First aid: Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. SKIN: Symptoms: Dry skin. First aid: Remove contaminated clothes. Rinse skin with plenty of water or shower. EYES: Symptoms: Redness. Pain. First aid: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. INGESTION: Symptoms: Dizziness. Drowsiness. Vomiting. First aid: Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Water may be ineffective ... But water should be used to keep fire-exposed containers cool. Use water spray dry chemical, foam, or carbon dioxide.

5.2 Specific hazards arising from the chemical

Behavior in Fire: Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back. Decomposes violently when heated. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Spills and leakage: Absorb with paper. Evaporate completely all spilt surface. Dispose by burning the paper after complete ventilation of vapor.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants. See Chemical Dangers. Cool. Keep in the dark. Store only if stabilized.Separate from oxidizing materials. Store in a cool, dry, well-ventilated area. Avoid sunlight.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH questioned whether the PEL proposed by OSHA for ethyl ether [TWA 400 ppm; STEL 500 ppm] was adequate to protect workers from recognized health hazards.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Clear liquid
Colour Colorless, volatile, mobile liquid
Odour Sweetish, pungent odor
Melting point/ freezing point -116ºC
Boiling point or initial boiling point and boiling range 34.6°C(lit.)
Flammability Class IA Flammable Liquid: Fl.P. below 22.78°C and BP below 37.78°C.Extremely flammable.
Lower and upper explosion limit / flammability limit Lower flammable limit: 1.9% by volume; Upper flammable limit: 36.0% by volume
Flash point -40°C
Auto-ignition temperature 160°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity 0.2448 centipoise at 20°C
Solubility In water:69 g/L (20 ºC)
Partition coefficient n-octanol/water (log value) log Kow= 0.89
Vapour pressure 28.69 psi ( 55 °C)
Density and/or relative density 0.706g/mLat 25°C(lit.)
Relative vapour density 2.6 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

It is slowly oxidized by action of air, moisture, and light, with formation of peroxides.

10.3 Possibility of hazardous reactions

When shaken under absolutely dry conditions ether can generate enough static electricity to start a fire.The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.Occasional explosions have occurred when aluminum hydride was stored in ether. The explosions have been blamed on the presence of carbon dioxide impurity in the ether, [J. Amer. Chem. Soc. 70:877(1948)]. Diethyl ether and chromium trioxide react violently at room temperature. Solid acetyl peroxide in contact with ether or any volatile solvent may explode violently. A 5-gram portion in ether detonated while being carried, [Chem. Eng. News 27:175(1949)]. Nitrosyl perchlorate ignites and explodes with diethyl ether. A mixture of ether and ozone forms aldehyde and acetic acid and a heavy liquid, ethyl peroxide, an explosive, [Mellor 1:911(1946-1947)].

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Boron triazide, bromine trifluoride, bromine pentafluoride, bromine, iodine heptafluoride, silver perchlorate, fluorine nitrate, permanganic acid, nitric acid, hydrogen peroxide, peroxodisulfuric acid, iodine(VII) oxide, peat soils, thiotriazyl perchlorate, sulfonyl chloride, sulfur, uranyl nitrate, and wood pulp extracts.

10.6 Hazardous decomposition products

When heated to decomposition it emits acrid smoke and irritating fumes.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 3.56 (3.23 - 3.92 g/kg in a single vehicle) /From table/
  • Inhalation: LC50 Mouse inhalation 186 mg/L/90 min
  • Dermal: LD50 Rabbit percutaneous 20 mL/kg. /From table/

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50 Pimephales promelas (fathead minnow, age 29 days) 2560 mg/L/96 hr; flow-through, 24.8°C, pH 7.76, dissolved oxygen 7.1 mg/L, hardness 45.1 mg/L CaCO3, alkalinity 41.5 mg/L CaCO3
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea); Conditions: freshwater, static, pH 8.0; Concentration: 165 mg/L for 24 hr; Effect: behavior, equilibrium
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Diethyl ether has been included in a list of compounds which were not biodegraded in a relatively short time either in screening tests which utilized sewage sludge inocula or soil inocula(1). Many ethers are known to be resistant to biodegradation(1). The 5-day biological oxygen demand measured for diethyl ether in screening tests ranged from 0%(2,3) to approximately 1.1%(2) in studies using the standard dilution technique with sewage inocula and 0% in a screening study using an activated sludge inoculum(4). A lag time of >10 days was observed in the latter study with activated sludge(4). In a study which used the seawater dilution method with a sewage inoculum, 0% theoretical BOD was observed over a 5-day period(3). No change was observed in the biological oxygen demand in tests of a semi-continuous activated sludge biological treatment simulator which tested for the removal of diethyl ether at a concn of 200 to 800 ppm in a domestic sewage feed over a period of 24 hours(5). A biodegradation study of diethyl ether, based on TOC measurements (GC analysis), using an activated sludge seed and an initial diethyl ether concn of 100 mg/L, indicated 2.5% (6.5%) biodegradation over a period of 4 weeks(6).

12.3 Bioaccumulative potential

BCF values of 0.9 to 1.4 and <1.7 to 9.1 were measured for carp exposed to 500 and 50 ug/L of diethyl ether over the course of a 6 week incubation period(1). According to a classification scheme(2), these BCFs suggest bioconcentration in aquatic organisms is low.

12.4 Mobility in soil

The Koc of diethyl ether is estimated as approximately 73(SRC), using a log Kow of 0.89(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diethyl ether is expected to have high mobility in soil(SRC). A vapor-phase partition coefficient of 15.49 was measured for diethyl ether at 30°C in the silt and clay size fraction of a calcareous soil (1.2% organic carbon w/w) from Southern Nevada at 52% relative humidity(4).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1155 IMDG: UN1155 IATA: UN1155

14.2 UN Proper Shipping Name

ADR/RID: DIETHYL ETHER (ETHYL ETHER)
IMDG: DIETHYL ETHER (ETHYL ETHER)
IATA: DIETHYL ETHER (ETHYL ETHER)

14.3 Transport hazard class(es)

ADR/RID: 8 IMDG: 8 IATA: 8

14.4 Packing group, if applicable

ADR/RID: I IMDG: I IATA: I

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Diethyl ether Diethyl ether 60-29-7 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 13, 2017
Revision Date Aug 13, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS Expand
1H NMR : parameter in CDCl3Expand

NMR Spectrum 1H NMR : parameter in CDCl3

Collapse

C4 H10 O 0.04 ml : 0.5 ml CDCl3
diethyl ether

Parameter ppm Hz
D(A) 3.472
D(B) 1.206
J(A,B) 7.00

IR : liquid filmExpand
Mass spectrum (electron ionization)Expand
Raman : 4880 A,200 M,liquidExpand

GC Analysis

Total 49 Documents >>
Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
Packed OV-1 130. 495. isothermal
Packed SE-30 100. 496. isothermal
Packed Squalane 50. 478. isothermal
Packed Porapack Q 200. 486. isothermal
Packed Apiezon L 120. 473. isothermal
Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
Administration into the eye Standard Draize test Human 100 ppm -
Oral LDLo - Lowest published lethal dose Human - man 260 mg/kg 1.Details of toxic effects not reported other than lethal dose value
Inhalation TCLo - Lowest published toxic concentration Human 200 ppm 1.Sense Organs and Special Senses (Olfaction)-effect, not otherwise specified
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