2-ethoxyethanol
CAS No.: 110-80-5 Formula: C4H10O2 Molecular Weight: 90.12100
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2-ethoxyethanol

CAS No.: 110-80-5 Formula: C4H10O2 Molecular Weight: 90.12100
Suppliers: All (73) China Suppliers (73) Price Available (16) Contractor (7)

Description

2-Ethoxyethanol, also known by the trademark Cellosolve or ethyl cellosolve, is a solvent used widely in commercial and industrial applications. It is a clear, colorless, nearly odorless liquid that is miscible with water, ethanol, diethyl ether, acetone, and ethyl acetate.
2-Ethoxyethanol can be manufactured by the reaction of ethylene oxide with ethanol.
As with other glycol ethers, 2-ethoxyethanol has the useful property of being able to dissolve chemically diverse compounds. It will dissolve oils, resins, grease, waxes, nitrocellulose, and lacquers. This is an ideal property as a multi-purpose cleaner, and, therefore, 2-ethoxyethanol is used in products, such as varnish removers and degreasing solutions.

Properties

Appearance & Physical State clear, colorless, nearly odorless liquid
Density 0.93
Boiling Point 135ºC
Melting Point -100ºC
Freezing Point -70℃
Flash Point 44ºC
Refractive Index 1.406-1.41
Water Solubility miscible
Stability Stable. Readily forms explosive mixtures with air - note the wide explosion range. Vapour may travel considerable distance to a source of ignition. Flammable. Incompatible with strong acids, strong bases, strong oxidizing agents, aluminium, alkalies.
Storage Condition Flammables area
Vapor Density 3.1 (vs air)
Vapor Pressure 3.8 mm Hg ( 20 °C)

Safety Info

RTECS KK8050000
Hazard Class 3
Safety Statements S45-S53
HS Code 2909499000
WGK Germany 1
Packing Group III
RIDADR UN 1171
Risk Statements R10; R20/21/22; R60; R61
Hazard Codes T
Symbol GHS02, GHS06, GHS08
Caution Statement P201; P210; P280; P304 + P340 + P312; P308 + P313; P370 + P378
Hazard Declaration H226; H302; H331; H360
Signal Word Danger
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SDS 1.0

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-ethoxyethanol

1.2 Other means of identification

Product number -
Other names 2-hydroxyethyl ethyl ether

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 3

Acute toxicity - Oral, Category 4

Acute toxicity - Inhalation, Category 3

Reproductive toxicity, Category 1B

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H226 Flammable liquid and vapour

H302 Harmful if swallowed

H331 Toxic if inhaled

H360FD

Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

Response

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P311 Call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P308+P313 IF exposed or concerned: Get medical advice/ attention.

Storage

P403+P235 Store in a well-ventilated place. Keep cool.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
2-ethoxyethanol 2-ethoxyethanol 110-80-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Some eye irritation. Inhalation of vapors causes irritation of nose. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Emergency and supportive measures. 1. Maintain an open airway and assist ventilation if necessary. Administer supplemental oxygen. 2. Treat coma, convulsions, cardiac arrhythmia and metabolic acidosis if they occur. Observe the patient for several hours to monitor for development of metabolic acidosis, especially if the patient is symptomatic or there is a known co-ingestion of ethanol. 3. Treat hypocalcemia with intravenous calcium gluconate or calcium chloride. /Ethylene glycol and other glycols/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Toxic gases, such as carbon monoxide, may be produced in fire. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Remove all ignition sources. Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Wash away remainder with plenty of water.

6.3 Methods and materials for containment and cleaning up

Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants and food and feedstuffs. Keep in the dark. Cool.Conditions for safe storage: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 0.5 ppm (1.8 mg/cu m). Skin designation.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state clear, colorless, nearly odorless liquid
Colour Colorless liquid
Odour Sweet, pleasant, ether-like odor
Melting point/ freezing point -100ºC
Boiling point or initial boiling point and boiling range 135°C(lit.)
Flammability Class II Combustible Liquid: Fl.P. at or above 37.78°C and below 60°C.Flammable.
Lower and upper explosion limit / flammability limit Upper 15.6% at 93°C; lower 1.7% at 93°C
Flash point 42°C
Auto-ignition temperature 237.78°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity 1.84 centipoise at 25°C
Solubility In water:miscible
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 3.8 mm Hg ( 20 °C)
Density and/or relative density 0.93g/mLat 25°C(lit.)
Relative vapour density 3.1 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Flammable in the presence of a source of ignition when the temperature is above the flash point.ETHYLENE GLYCOL MONOMETHYL ETHER may react with oxidizing materials, i.e. hydrogen peroxide, to form peroxides. It dissolves many oils, resins and waxes.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Polyacrylamide gels were dissolved in 30% peroxide solution and added to a scintillation mixture in 1:1 2-ethoxyethanol-toluene. After counting, the mixtures were bulked and evaporated intermittently with heat during a 4 week period, and the accumulated peroxidised residues eventually exploded violently. A subsequent comment indicated that peroxidised materials may not peroxide are themselves potentially explosive.

10.6 Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 1746 mg/kg bw
  • Inhalation: LC50 Guinea pig inhalation 3000 ppm/8 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill); Concentration: >10000 mg/L for 96hr /Conditions of bioassay not specified in source examined
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Ethylene glycol monoethyl ether, present at 100 mg/L, reached 76% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). In pilot-scale activated sludge systems, ethylene glycol monoethyl ether was reduced from 2,284 mg/L in the feed to 18 mg/L in the effluent(2). No ethylene glycol monoethyl ether was detected in the off-gas or waste mixed liquor samples(2).

12.3 Bioaccumulative potential

An estimated BCF value of 3 was calculated for ethylene glycol monoethyl ether(SRC), using a log Kow of -0.32(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of ethylene glycol monoethyl ether is estimated as 2(SRC), using a log Kow of -0.32(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that ethylene glycol monoethyl ether is expected to have very high mobility in soil(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1171 IMDG: UN1171 IATA: UN1171

14.2 UN Proper Shipping Name

ADR/RID: ETHYLENE GLYCOL MONOETHYL ETHER
IMDG: ETHYLENE GLYCOL MONOETHYL ETHER
IATA: ETHYLENE GLYCOL MONOETHYL ETHER

14.3 Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
2-ethoxyethanol 2-ethoxyethanol 110-80-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS Expand
1H NMR : 90 MHz in CDCl3Expand

NMR Spectrum 1H NMR : 90 MHz in CDCl3

Collapse

C4 H10 O2 0.04 ml : 0.5 ml CDCl3
ethylene glycol monoethyl ether

Assign. Shift(ppm)
A 3.72
B 3.55
C 3.55
D 2.70
E 1.224

IR : liquid filmExpand
Mass spectrum (electron ionization)Expand
Raman : 4880 A,100M,liquidExpand

GC Analysis

Total 25 Documents >>
Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
Capillary SPB-1 60. 687. isothermal
Packed Porapack Q 200. 671. isothermal
Packed SE-30 150. 694. isothermal
Packed Apiezon L 120. 666. isothermal
Packed Apiezon L 160. 670. isothermal
Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
Administration into the eye Standard Draize test Human 6000 ppm -
Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 2125 mg/kg 1.Behavioral-somnolence (general depressed activity)
2.Behavioral-withdrawal
3.Lungs, Thorax, or Respiration-respiratory depression
Inhalation LC50 - Lethal concentration, 50 percent kill Rodent - rat 2000 ppm/7H 1.Details of toxic effects not reported other than lethal dose value
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