107-21-1 structure, C2H6O2
Ethylene glycol
CAS No.: 107-21-1 Formula: C2H6O2 Molecular Weight: 62.06780
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Ethylene glycol

CAS No.:




Molecular Weight: 62.06780
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Ethylene glycol (IUPAC name: ethane-1,2-diol) is an organic compound with the formula (CH2OH)2. It is mainly used for two purposes, as a raw material in the manufacture of polyester fibers and for antifreeze formulations. It is an odorless, colorless, sweet-tasting syrup. Ethylene glycol is moderately toxic.

Basic Info

Chemical Name

Ethylene glycol


1,2-dihydroxy ethane; Ethane-1,2-diol; 1,2-Ethanediol; 1,2-Dihydroxyethane; 2-hydroxy ethanol;



Molecular Formula


Molecular Weight






Numbering system

PubChem number 24859450
EINECS number 203-473-3
MDL number MFCD00283324
RTECS number KW2975000
BRN number 505945


Appearance & Physical State

clear viscous liquid


1.220 g/mL at 25ºC

Boiling Point


Melting Point


Freezing Point


Flash Point


Refractive Index


Water Solubility



Stable at room temperature in closed containers under normal storage and handling conditions.

Storage Condition


Vapor Density

2.1 (vs air)

Vapor Pressure

0.08 mm Hg ( 20 °C)

Safety Info



Safety Statements


HS Code


WGK Germany



UN 1219 3/PG 2

Risk Statements


Hazard Codes



GHS07, GHS08

Hazard Declaration

H302; H373

Caution Statement

P260; P301 + P312 + P330

Signal Word


SDS 1.0


SDS 1.0

Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search


According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name Ethylene glycol

1.2 Other means of identification

Product number -
Other names 1,2-dihydroxy ethane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Ethylene glycol is used as antifreeze in cooling and heating systems, in hydraulic brake fluids, as an industrial humectant, as an ingredient of electrolytic condensers, as a solvent in the paint and plastics industries, in the formulations of printers' inks, stamp pad inks, and inks for ballpoint pens, as a softening agent for cellophane, and in the synthesis of safety explosives, plasticizers, synthetic fibers (Terylene, Dacron), and synthetic waxes. Ethylene glycol is also used to de-ice airport runways and aircraft. (2)
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

2.2 GHS label elements, including precautionary statements

Signal word


Hazard statement(s)

H302 Harmful if swallowed

Precautionary statement(s)

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.


P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.




P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification


3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Ethylene glycol Ethylene glycol 107-21-1 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Inhalation of vapor is not hazardous. Ingestion causes stupor or coma, sometimes leading to fatal kidney injury. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ethylene glycol, glycols, and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

In case of fire in the surroundings: carbon dioxide, foam, powder, water spray.

5.2 Specific hazards arising from the chemical

This chemical is combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

6.3 Methods and materials for containment and cleaning up

Collect leaking liquid in covered containers. Wash away spilled liquid with plenty of water.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants and strong bases. Dry. Ventilation along the floor.Polyethylene glycols should be stored in well-closed containers in a cool, dry place. Stainless steel, aluminum, glass, or lined steel containers are preferred for the storage of liquid grades.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state clear viscous liquid
Colour Clear, colorless, viscous liquids to waxy solids
Odour no data available
Melting point/ freezing point -13°C(lit.)
Boiling point or initial boiling point and boiling range 195-198°C
Flammability Combustible.
Lower and upper explosion limit / flammability limit no data available
Flash point 111°C
Auto-ignition temperature 400°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity /p>PEG 400: 105 to 130 mPa.s at 20 °C; PEG 3000: 75 to 100 mPa.s at 20 °C; PEG 3350: 83 to 120 mPa.s at 20 °C; PEG 4000: 110 to 170 mPa.s at 20 °C; PEG 6000: 200 to 270 mPa.s at 20 °C; PEG 8000: 260 to 510 mPa.s at 20 °C; For polyethylene glycols having a average molecular weight greater than 400, the viscosity is determined on a 50 per cent m/m solution of the candidate substance in water
Solubility In water:miscible
Partition coefficient n-octanol/water (log value) -1.93
Vapour pressure 0.08 mm Hg ( 20 °C)
Density and/or relative density 1.113g/mLat 25°C(lit.)
Relative vapour density 2.1 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Polyethylene glycols are chemically stable in air and in solution, although grades with a mol wt < 2000 are hygroscopic. Polyethylene glycols do not support microbial growth, and they do not become rancid. Polyethylene glycols and aqueous polyethylene glycol solutions can be sterilized by autoclaving, filtration, or gamma irradiation ... Ideally, sterilization should be carried out in an inert atmosphere.

10.3 Possibility of hazardous reactions

CombustibleVapors are heavier than air and will collect and stay in poorly-ventilated, low-lying, or confined areas (e.g., sewers, basements, and tanks).Hazardous concentrations may develop quickly in enclosed, poorly-ventilated, or low-lying areas. Keep out of these areas. Stay upwind.Mixing ETHYLENE GLYCOL in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, oleum, sulfuric acid, [NFPA 1991].

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Materials to avoid: Strong oxidizing agents.

10.6 Hazardous decomposition products

When heated to decomposition it emits acrid smoke and irritating fumes.

11.Toxicological information

Acute toxicity

  • Oral: Animal toxicity data for Polyethylene glycols (see Table) LD50 mg/kg PEG grade Guinea pig (oral) Mouse (ip) Mouse (iv) Mouse (oral) Rabbit (oral) Rabbit (iv) Rat (ip) Rat (iv) Rat (oral) 200 --- 7500 --- 3400 19900 --- --- --- 28000 300 19600 --- --- 17300 --- --- --- --- 27500 400 15700 10000 8600 28900 26800 --- 9700 7300 --- 600 --- --- --- 47000 --- --- --- --- 38100 1000 --- 20000 --- --- --- --- 15600 --- 44200 1500 28900 --- --- --- 28900 8000 17700 --- 44200 4000 50900 --- 16000 --- 76000 --- 11600 --- 50000 6000 50000 --- --- --- --- --- 6800 --- ---
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available



Reproductive toxicity

No information is available on the reproductive or developmental effects of ethylene glycol in humans. Several studies of rodents exposed orally or by inhalation showed ethylene glycol to affect animal fetuses. Fetotoxicity manifested as increased preimplantation loss, delayed ossification, and an increased incidence of fetal malformations were reported. The inhalation study, however, noted continuous grooming of the fur, resulting in a high rate of exposure by ingestion as well.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Oncorhynchus mykiss (Rainbow trout, weight 25-50 g); Conditions: freshwater, static, 14°C, pH 7.2, dissolved oxygen 10 mg/L; Concentration: >20000000 ug/L for 96 hr /PEG400
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

... will not support mold growth

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods


The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN3082 IMDG: UN3082 IATA: UN3082

14.2 UN Proper Shipping Name


14.3 Transport hazard class(es)


14.4 Packing group, if applicable


14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Ethylene glycol Ethylene glycol 107-21-1 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%


  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.


1H NMR : in CDCl3Expand

NMR Spectrum 1H NMR : in CDCl3


C2H6O2 0.019 g : 0.5 ml CDCl3

107-21-1 NMR spectrum

Assign. Shift(ppm)
A 3.716
B 3.17

Assigned with HMQC and HMBC.

IR : liquid filmExpand
Mass Expand
Raman : 4880 A,150M,liquidExpand

GC Analysis

Total 19 Documents >>
Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
Packed SE-30 150. 705. isothermal
Packed Apiezon L 160. 659. isothermal
Packed PEG-2000 179. 1695. isothermal
Packed PEG-2000 180. 1652. isothermal
Packed PEG-2000 200. 1667. isothermal
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