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2,2'-Dichlorodiethyl ether
CAS No.: 111-44-4 Formula: C4H8Cl2O Molecular Weight: 143.01200
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2,2'-Dichlorodiethyl ether

CAS No.: 111-44-4 Formula: C4H8Cl2O Molecular Weight: 143.01200
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Description

Bis(chloroethyl) ether is a chemical compound (an ether), which contains two 2-chloroethyl groups. It is a clear liquid with the odor of a chlorinated solvent.

Basic Info

Chemical Name 2,2'-Dichlorodiethyl ether
Synonyms

1-chloro-2-(2-chloroethoxy)ethane; Bis(2-chloroethyl) Ether; Bis(2-Chloroethyl)ether; 2,2'-Dichlorodiethyl Ether; 2-Chloroethyl ether; Ethane, 1,1‘-oxybis[2-chloro-; Expand

CAS No. 111-44-4
Molecular Formula C4H8Cl2O
Molecular Weight 143.01200
PSA 9.23000
LogP 1.48060

Properties

Appearance & Physical State clear to pale yellow liquid
Density 1.22
Boiling Point 178.5ºC
Melting Point -52ºC
Flash Point 55ºC
Refractive Index 1.456-1.458
Water Solubility Slightly soluble. 1.72 g/100 mL
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
Storage Condition 2-8ºC
Vapor Pressure 0.4 mm Hg ( 20 °C)

Safety Info

RTECS KN0875000
Hazard Class 6.1
Safety Statements S27-S28-S36/37-S45-S7/9
HS Code 29091900
WGK Germany 2
Packing Group II
RIDADR UN 1916
Risk Statements R10; R26/27/28; R40
Hazard Codes T+
SDS Version: 1.0 Expand

SDS Version: 1.0

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2'-Dichlorodiethyl ether

1.2 Other means of identification

Product number -
Other names 2,2'-Dichlorodiethyl Ether

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Nitrosamines/ethers/alcohols
Uses advised against no data available

1.4 Supplier's details

Company XiXisys.com
Address XiXisys.com
Telephone XiXisys.com
Fax XiXisys.com

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 2

Acute toxicity - Dermal, Category 1

Acute toxicity - Inhalation, Category 2

Carcinogenicity, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H300 Fatal if swallowed

H310 Fatal in contact with skin

H330 Fatal if inhaled

H351 Suspected of causing cancer

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P262 Do not get in eyes, on skin, or on clothing.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P310 Immediately call a POISON CENTER/doctor/…

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P320 Specific treatment is urgent (see ... on this label).

P308+P313 IF exposed or concerned: Get medical advice/ attention.

Storage

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
2,2'-Dichlorodiethyl ether 2,2'-Dichlorodiethyl ether 111-44-4 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Half-upright position. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

This material is very toxic; the probable oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 ounce for a 150 pound person. It can be a central nervous system depressant in high concentrations. It is extremely irritating to the eyes, nose, and respiratory passages. It can penetrate the skin to cause serious and even fatal poisoning. Poisonous; may be fatal if inhaled, swallowed or absorbed through skin. (EPA, 1998)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Treat frostbite by rapid rewarming ... . /Ethers and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

WATER, FOAM, MIST, FOG, SPRAY, DRY CHEMICAL.

5.2 Specific hazards arising from the chemical

May form phosgene or hydrogen chloride in fires. There is danger of explosion when ethers are heated or exposed to flames or sparks. Ethers tend to form peroxides; when ethers containing peroxides are heated, they can detonate. May be ignited by heat, sparks, or flames. Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Decomposes in the presence of moisture to form hydrochloric acid. Emits toxic fumes when heated to decomposition. Reacts vigorously with oleum and chlorosulfonic acid. Ethers tend to form peroxides upon standing. Heating peroxide-containing ethers can cause detonation. (EPA, 1998)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: chemical protection suit. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF SPILL OR LEAK. 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN A SAFE PLACE (SUCH AS A FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR THE HOOD DUCTWORK. BURN THE PAPER IN A SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS. LARGE QUANTITIES CAN BE RECLAIMED.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from food and feedstuffs. See Chemical Dangers. Keep in the dark. Well closed.Store in a cool, dry, well-ventilated location. Store away form heat, oxidizing materials, strong acids, & sunlight.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH considers dichloroethyl ether to be a potential occupational carcinogen.

NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concn.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 ppm (30 mg/cu m).

Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 10 ppm (60 mg/cu m). Skin.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state clear to pale yellow liquid
Colour COLORLESS, CLEAR LIQ
Odour PUNGENT
Melting point/ freezing point -47°C(lit.)
Boiling point or initial boiling point and boiling range 178°C
Flammability Class II Combustible Liquid: Fl.P. at or above 37.78°C and below 60°C.Flammable. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 55°C
Auto-ignition temperature 368.89°C (USCG, 1999)
Decomposition temperature no data available
pH no data available
Kinematic viscosity 2.0653 cP @ 25°C
Solubility In water:Slightly soluble. 1.72 g/100 mL
Partition coefficient n-octanol/water (log value) log Kow= 1.29
Vapour pressure 0.4 mm Hg ( 20 °C)
Density and/or relative density 1.22
Relative vapour density 4.93 (EPA, 1998) (Relative to Air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

FLAMMABLE LIQUID WHEN EXPOSED TO HEAT, FLAME, OR OXIDANTS.The vapour is heavier than air.2,2'-DICHLORODIETHYL ETHER may form phosgene or hydrogen when heated to high temperature. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154]. Mixing in equal molar portions with the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid and oleum [NFPA 1991].

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

... IT DECOMPOSES IN PRESENCE OF MOISTURE TO FORM HYDROCHLORIC ACID.

10.6 Hazardous decomposition products

WHEN HEATED TO DECOMP, EMITS HIGHLY TOXIC FUMES OF /HYDROGEN CHLORIDE/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Mouse oral 136 mg/kg
  • Inhalation: Rat inhalation 700 ppm/6 hr killed all 5 animals
  • Dermal: LD50 Rabbit single percutaneous 0.3 ml/kg /From table/

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Cancer Classification: Group B2 Probable Human Carcinogen

Reproductive toxicity

No information is available on the developmental or reproductive effects of dichloroethyl ether in humans. In one animal study, no effects were observed on the reproductive tissues of the animals, but no tests on reproductive function were performed.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (cladoceran) 238,000 ug/l/48 hr /in static and unmeasured methodologies
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

Bis(2-chloroethyl) ether was added to Ohio River water at pH 7.2 and 22-25°C(1). Thirty-five days following the addition of bis(2-chloroethyl) ether to the water, 50% of the carbon dioxide theoretically derivable from bis(2-chloroethyl) ether was recovered. After a second addition of bis(2-chloroethyl) ether, only 9-10 days were required to observe 50% recovery of theoretical carbon dioxide, suggesting acclimation was necessary for optimal biodegradation rates(1). The absence of evidence of biodegradation in another study(2) may be attributed to an insufficiently long acclimation period (18 days)(SRC). Bis(2-chloroethyl) ether, present at 100 mg/l, reached 8.3% of its theoretical BOD in 3 weeks using an activated sludge inoculum(3).

12.3 Bioaccumulative potential

A BCF of 0.4 to 1.3 in carp(1) and a BCF of 11 in bluegills exposed to bis(2-chloroethyl) ether for 14 days(2) was observed. According to a classification scheme(3), these BCF values suggest that the potential for bioconcentration in aquatic organisms is low.

12.4 Mobility in soil

The Koc of bis(2- chloroethyl) ether is estimated as approximately 120(SRC), using a log Kow of 1.29(1) and a regression-derived equation(2,SRC). According to a classification scheme(3), this estimated Koc value suggests that bis(2-chloroethyl) ether is expected to have high mobility in soil(SRC). In a 140 cm long column containing Lincoln fine sand collected in Ada, OK, 86% of the applied bis(2-chloroethyl) ether reached 140 cm, indicating minimal adsorption to this soil(4).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1916 IMDG: UN1916 IATA: UN1916

14.2 UN Proper Shipping Name

ADR/RID: 2,2'-DICHLORODIETHYL ETHER
IMDG: 2,2'-DICHLORODIETHYL ETHER
IATA: 2,2'-DICHLORODIETHYL ETHER

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
2,2'-Dichlorodiethyl ether 2,2'-Dichlorodiethyl ether 111-44-4 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS Expand
1H NMR : 90 MHz in CDCl3Expand

NMR Spectrum 1H NMR : 90 MHz in CDCl3

Collapse

C4 H8 Cl2 O 0.05 ml : 0.5 ml CDCl3
bis(2-chloroethyl) ether

Assign. Shift(ppm)
A *1 3.77
B *1 3.66

IR : liquid filmExpand
Mass Expand
Raman : 4880 A,100M,liquidExpand

GC Analysis

Total 15 Documents >>
Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
Capillary DB-1 - 945.9 temperature ramp
Capillary OV-1 - 948. temperature ramp
Capillary SE-54 - 984. temperature ramp
Capillary Ultra-1 - 951.52 temperature ramp
Capillary DB-1 - 948. temperature ramp
Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
Administration onto the skin Open irritation test Rodent - rabbit 10 mg/24H -
Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 75 mg/kg 1.Details of toxic effects not reported other than lethal dose value
Inhalation LC50 - Lethal concentration, 50 percent kill Rodent - rat 330 mg/m3/4H 1.Details of toxic effects not reported other than lethal dose value
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