CAS No.: 74-87-3 Formula: CH3Cl Molecular Weight: 50.48750
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CAS No.: 74-87-3 Formula: CH3Cl Molecular Weight: 50.48750
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Chloromethane, also called methyl chloride, Refrigerant-40, R-40 or HCC 40, is a chemical compound of the group of organic compounds called haloalkanes. It was once widely used as a refrigerant. It is a colorless extremely flammable gas with a mildly sweet odor, which is, however, detected at possibly toxic levels. Due to concerns about its toxicity, it is no longer present in consumer products. Chloromethane was first synthesized by the French chemists Jean-Baptiste Dumas and Eugene Peligot in 1835 by boiling a mixture of methanol, sulfuric acid, and sodium chloride. This method is similar to that used today.

Basic Info

Chemical Name Chloromethane

Methane, chloro-;

CAS No. 74-87-3
Molecular Formula CH3Cl
Molecular Weight 50.48750
PSA 0.00000
LogP 0.85500


Appearance & Physical State colourless gas
Density 0.92
Boiling Point -24.2ºC
Melting Point -97ºC
Flash Point -46ºC
Refractive Index 1.0007
Stability Stable. May react violently or explosively with interhalogens, magnesium, zinc, potassium, sodium or their alloys. Incompatible with natural rubber and neoprene composites, but does not attack PVA. Highly flammable. May decompose upon exposure to moist air
Storage Condition 2-8ºC

Safety Info

RTECS PA6300000
Hazard Class 2.1
Safety Statements 9-16-33
HS Code 2903110000
WGK Germany 2
RIDADR UN 1993 3
Risk Statements R12
Hazard Declaration H220; H280; H351; H361fd; H373
Symbol GHS02, GHS08
Caution Statement P210; P281; P410 + P403
Signal Word Danger
SDS 1.0 Expand

SDS 1.0

Download/Modify | Technical supported by For US version, EU version (23 languages) and more, please refer to


According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name Chloromethane

1.2 Other means of identification

Product number -
Other names Methane, chloro-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Volatile organic compounds
Uses advised against no data available

1.4 Supplier's details


1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Gases under pressure: Compressed gas

Flammable gases, Category 1

Carcinogenicity, Category 2

Specific target organ toxicity – repeated exposure, Category 2

2.2 GHS label elements, including precautionary statements

Signal word


Hazard statement(s)

H220 Extremely flammable gas

H351 Suspected of causing cancer

Precautionary statement(s)

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.


P377 Leaking gas fire: Do not extinguish, unless leak can be stopped safely.

P381 In case of leakage, eliminate all ignition sources.

P308+P313 IF exposed or concerned: Get medical advice/ attention.

P314 Get medical advice/attention if you feel unwell.


P410+P403 Protect from sunlight. Store in a well-ventilated place.

P403 Store in a well-ventilated place.

P405 Store locked up.


P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification


3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Chloromethane Chloromethane 74-87-3 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

In case of skin contact

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention .

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

Inhalation causes nausea, vomiting, weakness, headache, emotional disturbances; high concentrations cause mental confusion, eye disturbances, muscular tremors, cyanosis, convulsions. Contact of liquid with skin may cause frostbite. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Flush eyes with water, and hospitalize. Treat with oxygen against shock, and, if indicated administer stimulants. Treat burns of skin in the usual way.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Toxic and irritating gases are generated in fires. Behavior in Fire: Containers may explode (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. NEVER direct water jet on liquid.

6.3 Methods and materials for containment and cleaning up

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains; Methods and materials for containment and cleaning up: Clean up promptly by sweeping or vacuum.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Ventilation along the floor.Keep container tightly closed in a dry and well-ventilated place. Contents under pressure. Moisture sensitive. Storage class (TRGS 510): Gases

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH considers methyl chloride to be a potential occupational carcinogen.

NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state colourless gas
Colour Colorless compressed gas or liquid
Odour Faint sweet ethereal odor
Melting point/ freezing point -91°C(lit.)
Boiling point or initial boiling point and boiling range ?24.2°C(lit.)
Flammability Flammable GasHighly flammable. Heating will cause rise in pressure with risk of bursting.
Lower and upper explosion limit / flammability limit Lower flammable limit: 8.1% by volume; Upper flammable limit: 17.4% by volume
Flash point 24°C(lit.)
Auto-ignition temperature 631.67°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity 0.00027 Pa.s at 20°C (liquid, 0.5 MPa)
Solubility Slightly soluble
Partition coefficient n-octanol/water (log value) log Kow = 0.91
Vapour pressure 760 mm Hg at --11.67°C ; 3672 mm Hg at 20°C
Density and/or relative density 0.915g/mLat 25°C(lit.)
Relative vapour density 1.74 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Chemical stability: Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Flammable gas. Very dangerous fire hazard when exposed to heat, flame or powerful oxidizers. ... May ignite on contact with aluminum chloride or powdered aluminum.The gas is heavier than air and may travel along the ground; distant ignition possible. The gas is heavier than air and may accumulate in lowered spaces causing a deficiency of oxygen. See Notes.METHYL CHLORIDE can react vigorously with oxidizing agents. May react explosively with sodium, potassium, sodium-potassium alloy, magnesium, zinc. Reacts with aluminum powder in the presence of catalytic amounts of aluminum chloride to form pyrophoric trimethylaluminum. When heated to decomposition, it emits highly toxic fumes of chlorine [Bretherick, 5th ed., 1995, p. 176].

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Incompatible materials: Strong oxidizing agents, Iron

10.6 Hazardous decomposition products

... In contact with moisture undergoes slow decomposition to hydrochloric acid and methanol.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 1800 mg/kg
  • Inhalation: LC50 Mouse inhalation 6300 mg/cu m/7 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available


The Human Health Assessment Group in EPA's Office of Health and Environmental Assessment has evaluated methyl chloride for carcinogenicity. According to their analysis, the weight-of-evidence for methyl chloride is group C, which is based on limited evidence in animals. No data are available for humans. As a group C chemical, methyl chloride is considered possibly carcinogenic to humans.

Reproductive toxicity

No studies were located concerning developmental or reproductive effects of methyl chloride in humans. Several inhalation studies have demonstrated that methyl chloride causes reproductive effects in animals, with effects such as testicular lesions, disrupted spermatogenesis, and decreased sperm production in male rats. Delayed fetal development was noted in rats exposed to the same concentration of methyl chloride that resulted in maternal toxicity.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Lepomis macrochirus (/Bluegill)/; Conditions: static bioassay in fresh water at 23°C, mild aeration applied after 24 hr; Concentration: 550 ppm for 96 hr
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Methyl chloride, present at 3.79-19.2 mg/L, reached 1% of its theoretical BOD in 4 weeks using an activated sludge inoculum concentration of 1 drop/L in the Japanese MITI test(1). Using OECD Guideline 301D (Ready Biodegradability: Closed Bottle Test) with an activated sludge inoculum, methyl chloride (at 3 mg/L) reached 77% degradation after 28 days of incubation(2). Direct measurements of methyl chloride degradation in coastal seawater from Nova Scotia indicated that loss of methyl chloride was due to microbial activity(3). Strains of bacteria isolated from terrestrial, freshwater, estuarine and marine environments have been shown to be capable of biodegrading methyl chloride(2,4). Methyl chloride was biodegraded in a soil microcosm(5).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated for methyl chloride in fish(SRC), using a log Kow of 0.91(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc for methyl chloride can be estimated to be 13(SRC). According to a classification scheme(2), this estimated Koc value suggests that methyl chloride is expected to have very high mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods


The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1063 IMDG: UN1063 IATA: UN1063

14.2 UN Proper Shipping Name


14.3 Transport hazard class(es)


14.4 Packing group, if applicable


14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Chloromethane Chloromethane 74-87-3 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%


  • IPCS - The International Chemical Safety Cards (ICSC), website:
  • HSDB - Hazardous Substances Data Bank, website:
  • IARC - International Agency for Research on Cancer, website:
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
  • CAMEO Chemicals, website:
  • ChemIDplus, website:
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:
  • Germany GESTIS-database on hazard substance, website:
  • ECHA - European Chemicals Agency, website:

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS Expand
1H NMR : parameter in CCl4Expand

NMR Spectrum 1H NMR : parameter in CCl4


C H3 Cl 10 wt% in CCl4

Parameter ppm Hz
D(A) 3.052

LACEY,M.J. ET AL. AUST.J.CHEM. 23, 1421 (1970)
J(GEM):-10.7HZ. J(C-13,H):150HZ.

GC Analysis

Total 14 Documents >>
Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
Packed Squalane 80. 329. isothermal
Packed Squalane 27. 324. isothermal
Packed Squalane 49. 326. isothermal
Packed Squalane 67. 327. isothermal
Packed Squalane 86. 329. isothermal
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