propan-2-ol
CAS No.: 67-63-0 Formula: C3H8O Molecular Weight: 60.09500
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propan-2-ol

CAS No.: 67-63-0 Formula: C3H8O Molecular Weight: 60.09500
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Description

Isopropyl alcohol (IUPAC name propan-2-ol), also called isopropanol or dimethyl carbinol, is a compound with the chemical formula C3H8O or C3H7OH or CH3CHOHCH3 (sometimes represented as i-PrOH). It is a colorless, flammable chemical compound with a strong odor. As a propyl group linked to a hydroxyl group, it is the simplest example of a secondary alcohol, where the alcohol carbon atom is attached to two other carbon atoms, sometimes shown as (CH3)2CHOH. It is a structural isomer of 1-propanol. It has a wide variety of industrial and household uses.

Basic Info

Chemical Name propan-2-ol
Synonyms

iso-Propyl alcohol; iso-propanol; Isopropanol; 2-Propanol; PriOH; isopropyl alcohol; i-propyl alcohol; Expand

CAS No. 67-63-0
Molecular Formula C3H8O
Molecular Weight 60.09500
PSA 20.23000
LogP 0.38710

Properties

Appearance & Physical State Colourless liquid
Density 0.785g/mL
Boiling Point 81-83ºC
Melting Point -89.5ºC
Freezing Point -89.5℃
Flash Point 12ºC
Refractive Index 1.376-1.378
Water Solubility miscible
Storage Condition Flammables area
Vapor Density 2.1 (vs air)
Vapor Pressure 33 mm Hg ( 20 °C)

Safety Info

RTECS NT8050000
Hazard Class 3
Safety Statements 7-16-24/25-26-36/37
HS Code 2905122000
WGK Germany 1
Packing Group II
RIDADR UN 1219
Risk Statements R11; R36; R67; R40; R10; R36/38
Hazard Codes F
Caution Statement P210; P280; P305 + P351 + P338; P337 + P313; P403 + P235
Symbol GHS02, GHS07
Signal Word Danger
Hazard Declaration H225; H319; H336
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SDS 1.0

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name propan-2-ol

1.2 Other means of identification

Product number -
Other names iso-Propyl alcohol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Antimicrobial Actives;Solvents;Surfactants
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 2

Eye irritation, Category 2

Specific target organ toxicity – single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H225 Highly flammable liquid and vapour

H319 Causes serious eye irritation

H336 May cause drowsiness or dizziness

Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash ... thoroughly after handling.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

Response

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P312 Call a POISON CENTER/doctor/…if you feel unwell.

Storage

P403+P235 Store in a well-ventilated place. Keep cool.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
propan-2-ol propan-2-ol 67-63-0 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Do NOT induce vomiting. Rest. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Vapors cause mild irritation of eyes and upper respiratory tract; high concentrations may be anesthetic. Liquid irritates eyes and may cause injury; harmless to skin; if ingested causes drunkenness and vomiting. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Lower alcohols (1-3 Carbons) and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Accidental Release Measures: Personal Precautions: Ensure adequate ventilation. Keep people away from and upwind of spill/leak. Avoid contact with skin, eyes and clothing. Use personal protective equipment. Remove all sources of ignition. Pay attention to flashback. Take precautionary measures against static discharges. All equipment used when handling the product must be grounded. Use spark-proof tools and explosion-proof equipment. In case of large spill, water spray or vapor suppressing foam may be used to reduce vapors, but may not prevent ignition in closed spaces. /Isopropyl Alcohol, Reagent, ACS/

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants. Cool. Well closed.Keep container tightly closed in a dry and well-ventilated place. Store at room temperature in the original container. Sensitive to light. Store in light-resistant containers. Keep away from heat and sources of ignition. Store in a segrated and approved area. Store away from incompatible materials. /Isopropyl Alcohol, Reagent, ACS/

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 400 ppm (980 mg/cu m).

Recommended Exposure Limit: 15 Minute Short-Term Exposure Limit: 500 ppm (1225 mg/cu m).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Colourless liquid
Colour Colorless liquid
Odour Pleasant odor
Melting point/ freezing point 7°C(lit.)
Boiling point or initial boiling point and boiling range 82°C(lit.)
Flammability Class IB Flammable Liquid: Fl.P. below 22.78°C and BP at or above 37.78°C.Highly flammable.
Lower and upper explosion limit / flammability limit Lower flammable limit: 2.0% by volume; Upper flammable limit: 12.7% by volume @ 200 deg F (93°C)
Flash point 12°C
Auto-ignition temperature 398.89°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity 2.038 mPa s at 25°C
Solubility In water:miscible
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 33 mm Hg ( 20 °C)
Density and/or relative density 0.785g/mLat 25°C(lit.)
Relative vapour density 2.1 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Preserve in tight containers, remove from heat.

10.3 Possibility of hazardous reactions

A very dangerous fire hazard when exposed to heat, flame or oxidizers.The vapour mixes well with air, explosive mixtures are easily formed.ISOPROPANOL reacts with air or oxygen to form dangerously unstable peroxides. Contact with 2-butanone increases the rate of peroxide formation. An explosive reaction occurs when it is heated with (aluminum isopropoxide + crotonaldehyde). Forms explosive mixtures with trinitromethane and hydrogen peroxide. Reacts with barium perchlorate to form a highly explosive compound. Ignites on contact with dioxygenyl tetrafluoroborate, chromium trioxide and potassium-tert-butoxide. Vigorous reactions occur with (hydrogen + palladium), nitroform, oleum, COCl2, aluminum triisopropoxide and oxidizing agents. Reacts explosively with phosgene in the presence of iron salts. Incompatible with acids, acid anhydrides, halogens and aluminum . Isopropanol can react with PCl3, forming toxic HCl gas. (Logsdon, John E., Richard A. Loke., "Isopropyl Alcohol." Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. 1996.).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

During distillation of 2-propanol recovered from the reduction of crotonaldehyde with aluminium isopropoxide, a violent explosion occurred. This was attributed either to peroxidized diisopropyl ether (a possible by-product) or to peroxidized crotonaldehyde.

10.6 Hazardous decomposition products

When heated to decomposition it emits acrid smoke and fumes.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Dog oral 4797 mg/kg
  • Inhalation: LC50 Mouse inhalation 53 mg/L 2 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Evaluation: There is inadequate evidence for the carcinogenicity of isopropanol in humans. There is inadequate evidence for the carcinogenicity of isopropanol in experimental animals. Overall evaluation: Isopropanol is not classifiable as to its carcinogenicity to humans (Group 3).

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill) length 40-50 mm; Conditions: static, 22°C; Concentration: >1400000 ug/L for 24-96 hr /formulation
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr neonate; Conditions: freshwater, static, 21°C, pH 7.6; Concentration: 114 mM for 24 hr; Effect: intoxication, immobilization
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Degradation of isopropanol with municipal waste water for 5 and 20 days resulted in a theoretical oxygen demand (ThOD) of 7% and 70%, respectively(1). Degradation of 3, 7 and 10 mg/L of isopropanol with filtered sewage seed in fresh water resulted in a ThOD of 28% in 5 days and 78% in 20 days(2). In 2 other studies, the ThOD for isopropanol using domestic waste water was 66% and 74% in 5 days(1). Isopropanol was 99% degraded with acclimated activated sludge at 20°C (52 mg COD/g-hr rate)(3). Filtered sewage seed resulted in a ThOD of 49% and acclimated sewage seed resulted in a ThOD of 72% after 5 days(4). Degradation of isopropanol with sewage at 20°C for 5 days resulted in a ThOD of 58% (avg 4 results)(5). In domestic waste water, diluted with salt water, a ThOD of 13% in 5 days and 72% in 20 days was observed(1). Biodegradation of 3, 7, and 10 mg/L of isopropanol with filtered sewage seed in salt water resulted in a ThOD of 13% in 5 days and a ThOD of 72% in 20 days(2). Isopropanol, present at 100 mg/L, reached 86% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test which determined isopropanol to be ready biodegradable(6).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for isopropanol(SRC), using a log Kow of 0.05(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc of isopropanol can be estimated to be 1.5(SRC). According to a classification scheme(2), this estimated Koc value suggests that isopropanol is expected to have very high mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1219 IMDG: UN1219 IATA: UN1219

14.2 UN Proper Shipping Name

ADR/RID: ISOPROPANOL (ISOPROPYL ALCOHOL)
IMDG: ISOPROPANOL (ISOPROPYL ALCOHOL)
IATA: ISOPROPANOL (ISOPROPYL ALCOHOL)

14.3 Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
propan-2-ol propan-2-ol 67-63-0 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS Expand
1H NMR : 90 MHz in CDCl3Expand

NMR Spectrum 1H NMR : 90 MHz in CDCl3

Collapse

C3 H8 O 0.04 ml : 0.5 ml CDCl3
2-propanol

Assign. Shift(ppm)
A 4.008
B 2.16
C 1.200

IR : liquid filmExpand
Mass Expand
Raman : 4880 A,150M,liquidExpand
ESR : OXIDATION WITH TI(III)/H2O2Expand
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