D-mannitol
CAS No.: 69-65-8 Formula: C6H14O6 Molecular Weight: 182.17200
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D-mannitol

CAS No.: 69-65-8 Formula: C6H14O6 Molecular Weight: 182.17200
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Description

Mannitol, also known as mannite or manna sugar, is a white, crystalline solid that looks and tastes sweet like sucrose. Medically it is used to treat increased intracranial pressure. It also has several industrial uses. In plants its purpose is to alleviate osmotic stress.
Serious side effects may include worsening heart failure, electrolyte abnormalities, or low blood volume. It is unclear if it is safe in pregnancy. Mannitol is classified as a sugar alcohol; that is, it is derived from a sugar (mannose) by reduction. Other sugar alcohols include xylitol and sorbitol. Mannitol and sorbitol are isomers, the only difference being the orientation of the hydroxyl group on carbon 2.
It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It was originally isolated from the flowering ash and called manna after its supposed resemblance to the Biblical food.

Basic Info

Chemical Name D-mannitol
Synonyms

D-Mannitol; [3H]-D-(-)-Mannitol; Cyt; [3H]-Cytosine; [14C]-D-(-)-Mannitol; Cytosinimine; Cytosine (100 mg); 4-aminopyrimidin-2-one; Cytosine API; Cytosin; Expand

CAS No. 69-65-8
Molecular Formula C6H14O6
Molecular Weight 182.17200
PSA 121.38000
LogP -3.58540

Properties

Appearance & Physical State white crystalline powder
Density 1.52
Boiling Point 295ºC
Melting Point 167-170ºC
Flash Point 100ºC
Refractive Index 1.333 (20ºC)
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
Storage Condition Store at RT.

Safety Info

Safety Statements S24/25
HS Code 2905430000
Risk Statements R36/37/38
Hazard Codes Xi
SDS 1.0 Expand

SDS 1.0

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name D-mannitol

1.2 Other means of identification

Product number -
Other names D-Mannitol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food Additives: BULKING_AGENT; HUMECTANT; STABILIZER; SWEETENER; TEXTURIZER; THICKENER
Uses advised against no data available

1.4 Supplier's details

Company XiXisys.com
Address XiXisys.com
Telephone XiXisys.com
Fax XiXisys.com

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
D-mannitol D-mannitol 69-65-8 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

SYMPTOMS: Symptoms of exposure to this compound include nausea, vomiting, headache, chills, chest pain and pulmonary edema. It may cause irritation of the skin, eyes and respiratory tract. Other symptoms may include lethargy, confusion, heart failure and death. Exposure has caused an electrolyte and fluid imbalance, hypersensitivity reactions, diarrhea, thirst, fever, tachycardia, hyponatremia, urinary retention, dehydration, blurred vision, convulsions, urticaria, hypotension and hypertension. It has also caused hyperglycemia and glycosuria. Coughing may result from inhalation. Ingestion may cause gastric irritation. Skin contact may cause discoloration of sensitive skin. Eye contact may cause redness and pain. Intravenous use has led to blood pressure elevation and bladder tubule changes. ACUTE/CHRONIC HAZARDS: This compound may cause irritation of the skin, eyes and respiratory tract. When heated to decomposition it emits acrid smoke and toxic fumes of carbon monoxide and carbon dioxide.

4.3 Indication of immediate medical attention and special treatment needed, if necessary

SIX PATIENTS WITH SEVERE MANNITOL INTOXICATION WERE TREATED WITH HEMODIALYSIS & ONE WITH PERITONEAL DIALYSIS. MANNITOL HAD HALF-LIFE OF APPROX 36 HR DURING INTERVALS WITHOUT TREATMENT. IDEAL TREATMENT IS HEMODIALYSIS WHICH RAPIDLY REMOVES MANNITOL (HALF-LIFE, 6 HR) & REPLACES IT WITH SODIUM; PERITONEAL DIALYSIS REMOVED MANNITOL SLOWLY (HALF-LIFE, 21 HR).

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.

5.2 Specific hazards arising from the chemical

This chemical is probably combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Mannitol solutions should be stored at room temperature and protected from freezing.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state white crystalline powder
Colour Orthorhombic needles from alc
Odour Odorless
Melting point/ freezing point 139°C(lit.)
Boiling point or initial boiling point and boiling range 166°C/17mmHg(lit.)
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 80°C(lit.)
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility greater than or equal to 100 mg/mL at 20°C
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure no data available
Density and/or relative density 1.52
Relative vapour density no data available
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Mannitol 25% (Invenex) was chemically and physically stable after five autoclavings at 250 deg F for 15 min.

10.3 Possibility of hazardous reactions

A sugar alcohol. More closely related to carbohydrates than to other polyhydric alcohols [Noller]. Flammable and/or toxic gases are generated by the combination with alkali metals, nitrides, strong reducing agents and strong oxidizing agents.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

It has been stated that mannitol is incompatible in strongly acidic and alkaline solutions.

10.6 Hazardous decomposition products

When heated to decomposition it emits acrid smoke and fumes.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 13,500 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

D-Mannitol is a simple sugar alcohol and should be readily biodegraded in the environment. (SRC)

12.3 Bioaccumulative potential

An estimated BCF of 1 was calculated for D-mannitol(SRC), using a water solubility of 2.16X10+5 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of D-mannitol is estimated as approximately 5(SRC), using a water solubility of 2.16X10+5 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that D-mannitol is expected to have very high mobility in soil(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.2 UN Proper Shipping Name

ADR/RID: unknown
IMDG: unknown
IATA: unknown

14.3 Transport hazard class(es)

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.4 Packing group, if applicable

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
D-mannitol D-mannitol 69-65-8 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS Expand
1H NMR : 400 MHz in DMSO-d6Expand

NMR Spectrum 1H NMR : 400 MHz in DMSO-d6

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C6 H14 O6 0.041 g : 0.5 ml DMSO-d6
D-mannitol

Assign. Shift(ppm)
A 4.42
B 4.35
C 4.15
D 3.610
E 3.540
F 3.45
G 3.38

ASSIGNED BY H-H COSY.
J(A,F)=5.4HZ
J(B,D)=J(B,G)=5.7HZ
J(C,E)=7.1HZ
J(D,G)=-10.7HZ
J(D,F)=3.3HZ
J(G,F)=5.6HZ

IR : KBr discExpand
Mass spectrum (electron ionization)Expand
Raman : 4880 A,200 M,powderExpand
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