N,N-dimethylnitrous amide
CAS No.: 62-75-9 Formula: C2H6N2O Molecular Weight: 74.08180
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N,N-dimethylnitrous amide

CAS No.: 62-75-9 Formula: C2H6N2O Molecular Weight: 74.08180
Suppliers: All (9) China Suppliers (9) Price Available (2) Contractor(0)

Description

N-Nitrosodimethylamine (NDMA), also known as dimethylnitrosamine (DMN), is a semi-volatile organic chemical, produced as by-product of several industrial processes and present at very low levels in certain foodstuffs, especially those cooked, smoked, or cured. NDMA is water-soluble, colorless, and its taste and odor are weak or absent. It is toxic to the liver and other organs.

Properties

Appearance & Physical State yellow oily liquid
Density 1.01 g/mL(lit.)
Boiling Point 151 - 154ºC
Melting Point 50ºC
Flash Point 61ºC
Refractive Index n20/D 1.437(lit.)
Stability Stability Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases, strong reducing agents.
Storage Condition 2-8ºC
Vapor Pressure 5 mm Hg ( 20 °C)

Safety Info

RTECS IQ0525000
Hazard Class 6.1(b)
Safety Statements S45-S53-S61
WGK Germany 3
Packing Group III
RIDADR UN 3382 6.1/PG 1
Risk Statements R45; R25; R26; R48/25; R51/53; R39/23/24/25; R23/24/25; R11
Hazard Codes T+; N; F
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N-dimethylnitrous amide

1.2 Other means of identification

Product number -
Other names N-NITROSODIMETHYLAMINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Nitrosamines/ethers/alcohols
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Inhalation, Category 2

Carcinogenicity, Category 1B

Specific target organ toxicity – repeated exposure, Category 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H301 Toxic if swallowed

H330 Fatal if inhaled

H350 May cause cancer

H411 Toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P273 Avoid release to the environment.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P310 Immediately call a POISON CENTER/doctor/…

P320 Specific treatment is urgent (see ... on this label).

P308+P313 IF exposed or concerned: Get medical advice/ attention.

P314 Get medical advice/attention if you feel unwell.

P391 Collect spillage.

Storage

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
N,N-dimethylnitrous amide N,N-dimethylnitrous amide 62-75-9 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Give a slurry of activated charcoal in water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: nausea, vomiting, diarrhea, abdominal cramps; headache; fever; enlarged liver, jaundice; decreased liver, kidney, pulmonary function; [Potential occupational carcinogen] Target Organs: Liver, kidneys,lungs Cancer Site [in animals; lung, kidney, liver & nasal cavity tumors] (NIOSH, 2016)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Irrigate eyes with water. Wash contaminated areas of body with soap and water.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

/Fire fighters should wear/ any self-contained breathing apparatus with a full facepiece and operated in a pressure demand or other positive pressure mode.

5.2 Specific hazards arising from the chemical

When heated to decomposition, it emits toxic fumes of nitrogen oxides. Avoid exposure to ultraviolet light. (EPA, 1998)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Evacuate danger area! Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

SPILLS OF N-NITROSODIETHYLAMINE CAN BE ABSORBED BY CELITE OR COMMERCIAL SPILL ABSORBANT. AFTER ABSORBANT CONTAINING MAJOR SHARE OF NITROSAMINE HAS BEEN PICKED UP (AVOID DUSTS; DO NOT SWEEP), SURFACE SHOULD BE THOROUGHLY CLEANED WITH STRONG DETERGENT SOLN. IF MAJOR SPILL OCCURS OUTSIDE OF VENTILATED AREA, ROOM SHOULD BE EVACUATED & CLEANUP OPERATION SHOULD BE CARRIED OUT BY PERSONS EQUIPPED WITH SELF-CONTAINED RESPIRATORS. THOSE INVOLVED IN THIS OPERATION SHOULD WEAR RUBBER GLOVES, LAB COATS, & PLASTIC APRONS OR EQUIVALENT PROTECTIVE APPAREL. /N-NITROSODIETHYLAMINE, ALSO APPLICABLE TO OTHER DIALKYLNITROSAMINES/

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants and food and feedstuffs. Cool. Keep in the dark. Well closed.ALL BOTTLES OF N-NITROSODIETHYLAMINE SHOULD BE STORED & TRANSPORTED WITHIN UNBREAKABLE OUTER CONTAINER; STORAGE SHOULD BE IN VENTILATED STORAGE CABINET (OR IN HOOD). /N-NITROSODIETHYLAMINE, ALSO APPLICABLE TO OTHER DIALKYLNITROSAMINES/

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH considers N-nitrosodimethylamine to be a potential occupational carcinogen.

NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state yellow oily liquid
Colour Yellow, oily liquid
Odour Faint, characteristic odor
Melting point/ freezing point 16°C(lit.)
Boiling point or initial boiling point and boiling range 208°C(lit.)
Flammability Combustible LiquidCombustible.
Lower and upper explosion limit / flammability limit no data available
Flash point -8°C(lit.)
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity Low
Solubility greater than or equal to 100 mg/mL at 18.89°C
Partition coefficient n-octanol/water (log value) log Kow = -0.57
Vapour pressure 5 mm Hg ( 20 °C)
Density and/or relative density 1.01 g/mL(lit.)
Relative vapour density 2.56 (Relative to Air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable at room temperature for more than 14 days in neutral or alkaline solutions in the dark; slightly less stable in acidic solutions; sensitive to UV light.

10.3 Possibility of hazardous reactions

CombustibleN-NITROSODIMETHYLAMINE is sensitive to exposure to light, especially ultraviolet light. Is stable at room temperature for more than 14 days in aqueous solution at neutral and alkaline pH in the absence of light. Slightly less stable at strongly acid pH at room temperature. Incompatible with strong oxidizing agents. Also incompatible with strong bases. Can be reduced by reducing agents. Incompatible with hydrogen bromide in acetic acid. Also photochemically reactive.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Oxidants, especially peracids. Sensitive to UV light.

10.6 Hazardous decomposition products

When heated to decomp it emits toxic fumes of /oxides of nitrogen/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 27-41 mg/kg
  • Inhalation: LC50 Rat inhalation 78 ppm/4 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

NTP: Reasonably anticipated to be a human carcinogen

Reproductive toxicity

No information is available on the reproductive or developmental effects of N-nitrosodimethylamine in humans. In a study of rats exposed to N-nitrosodimethylamine by injection, increased fetal mortality was observed but no birth defects were noted. N-Nitrosodimethylamine, when administered to pregnant rats, mice, and hamsters by several routes, has been shown to cause cancer in the offspring.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LD50; Species: Oncorhynchus mykiss (Rainbow trout) ip 1770 mg/kg for 10 days
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: EC50; Species: Anabaena flosaquae (Blue-Green Algae) 10000 cells; Conditions: freshwater, static, 24°C; Concentration: 5100 ug/L for 96 hr; Effect: growth, general
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

No biodegradation of dimethylnitrosamine was observed in lake water samples during an observation period of 3.5 months, and a lag of nearly 30 days occurred before its slow disappearance from soil. The nitrosamine appeared to be degraded very slowly in sewage, but it was not affected by the anaerobic organisms /found in collected bog sediments/.

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for N-nitrosodimethylamine(SRC), using a log Kow of -0.57(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Kd (soil distribution coefficient) values of 0.45-0.64 L/kg were measured for N-nitrosodimethylamine in turfgrass, ground cover and bare surface soils that corresponded to Koc values 68-118(1). Similar results were observed in a study of subsurface soil samples including sand, sandy loam and loamy sand soils with Kd values ranging from 0.4-1.2 L/kg(2). According to a recommended classification scheme(3), the Koc values suggests that N-nitrosodimethylamine is expected to have high mobility in soil(SRC). N-Nitrosodimethylamine was found to leach through 4 different soils as readily as chloride ion(4). Another study also found that N-nitrosodimethylamine readily leached through soils(5). The leaching risk of N-nitrosodimethylamine in soils receiving reclaimed wastewater depend upon the hydraulic conductivity of the soil and irrigation intensity(6); proper irrigation volumes can reduce the leaching risk(6).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN3382 IMDG: UN3382 IATA: UN3382

14.2 UN Proper Shipping Name

ADR/RID: TOXIC BY INHALATION LIQUID, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50
IMDG: TOXIC BY INHALATION LIQUID, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50
IATA: TOXIC BY INHALATION LIQUID, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
N,N-dimethylnitrous amide N,N-dimethylnitrous amide 62-75-9 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS Expand
1H NMR : parameter in CDCl3Expand

NMR Spectrum 1H NMR : parameter in CDCl3

Collapse

C2 H6 N2 O 0.04 ml : O.5 ml CDCl3
N-nitrosodimethylamine

Parameter ppm Hz
D(A) 3.804

D(B) 3.077

IR : liquid filmExpand
Mass spectrum (electron ionization)Expand
ESR : PHOTOLYSIS IN CH3COOH-H2O-DTBPO-2-PROPANOL, 22CExpand

GC Analysis

Total 2 Documents >>
Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
Capillary OV-101 - 708. temperature ramp
Capillary Methyl Silicone - 708. custom temperature program
Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
Oral LDLo - Lowest published lethal dose Human - woman 20 mg/kg/2.5Y 1.Gastrointestinal-ulceration or bleeding from small intestine
2.Gastrointestinal-nausea or vomiting
3.Nutritional and Gross Metabolic-body temperature increase
Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 37 mg/kg 1.Details of toxic effects not reported other than lethal dose value
Inhalation LC50 - Lethal concentration, 50 percent kill Rodent - rat 78 ppm/4H 1.Sense Organs and Special Senses (Eye)-effect, not otherwise specified
2.Behavioral-somnolence (general depressed activity)
3.Blood-hemorrhage
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