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DBCP 96-12-8 MSDS

Section I.Chemical Product and Company Identification
    Chemical Name        1,2-Dibromo-3-chloropropane (1mg/ml in Methanol)    
    [for Water Analysis]
    Portland OR
    Not available.
    Synonym
    Chemical Formula        C3H5Br2Cl    
    CAS Number        96-12-8    
    67-56-1 (Methanol)

Section II.        Composition and Information on Ingredients    
    Chemical Name        CAS Number Percent (%)        TLV/PEL        Toxicology Data    
    1,2-Dibromo-3-chloropropane (1mg/ml in Methanol)        ca. 0.13        This chemical is classified as a        Rat LD50 (oral) 170 mg/kg    
    96-12-8
    [for Water Analysis]
    ca. 99.87        carcinogen. There is no        Rabbit LD50 (dermal) 1400 mg/kg    
    67-56-1
    acceptable exposure limit for a        Rat LD50 (inhalation) 98 mg/m3/4H    
    (Methanol)
    carcinogen.        (Methanol)    
    Rat LD50 (oral) 5600 mg/kg
    Rabbit LD50 (dermal) 15800 mg/kg
    Rat LD50 (inhalation) 6400 ppm/4H

Section III. Hazards Identification
    Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
    Acute Health Effects
    Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
    eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
    occasionally, blistering.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
    CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria.
    Chronic Health Effects
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Tumorigenic effects.
    Rat TC Inhalation 600 ppb/6H for 76 weeks intermittent
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Sense Organs and Special Senses - Tumors
    Endocrine - Adrenal cortex tumors
    Rat TD Oral 9280 mg/kg for 64 weeks intermittent
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Gastrointestinal - Tumors
    Skin and Appendages - Tumors
    Rat TD Subcutaneous 240 mg/kg for 12 weeks intermittent
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Kidney, Ureter, and Bladder - Kidney tumors
    DEVELOPMENTAL TOXICITY: Reproductive effects.
    Rat TDLo Oral 375 mg/kg, male 75 days prior to mating
    Toxic Effects:
    Paternal Effects - Spermatogenesis
    Paternal Effects - Testes, epididymis, sperm duct
    Effects on Fertility - Male fertility index
    Rat TDLo Oral 250 mg/kg, male 5 days prior to mating
    Toxic Effects:
    Effects on Fertility - Post-implantation mortality
    Effects on Fertility - Litter size
    Rat TDLo Unreported 150 mg/kg, female 14-19 days of pregnancy
    Toxic Effects:
    Specific Developmental Abnormalities - Endocrine system
    Effects on Newborn - Growth statistics
    Effects on Newborn - Delayed effects
    DEVELOPMENTAL TOXICITY: Reproductive effects. (Methanol)
    Rat TCLo Inhalation 20000 ppm for 7 hours, female 1-22 days of pregnancy
    TOXIC EFFECTS:
    Specific Developmental Abnormalities – Musculoskeletal system
    Continued on Next Page
    1,2-Dibromo-3-chloropropane (1mg/ml in Methanol)
    [for Water Analysis]
    Specific Developmental Abnormalities – Cardiovascular system
    Specific Developmental Abnormalities – Urogenital system
    Rat TDLo Oral 35295 mg/kg, female 1-15 days of pregnancy
    TOXIC EFFECTS:
    Effects on Fertility – Female fertility index
    Effects on Fertility – Pre-implantation mortality
    Effects on Fertility – Post implantation mortality
    Mouse TDLo Oral 4 gm/kg, female 7 days of pregnancy
    TOXIC EFFECTS:
    Specific Developmental Abnormalities – Craniofacial
    Specific Developmental Abnormalities – Musculoskeletal system
    Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or
    many human organs.

Section IV.        First Aid Measures    
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15    
    minutes. Get medical attention.
    Skin Contact        In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing    
    and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately.
    Inhalation        If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or    
    waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
    improve.
    Ingestion        INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.    
    Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
    resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
    material was ingested; the absence of such signs, however, is not conclusive.

Section V.        Fire and Explosion Data    
    385°C (725°F) (Methanol)
    Flammability        Flammable.        Auto-Ignition    
    Flammable Limits        LOWER: 6% UPPER: 36% (Methanol)    
    Flash Points        77°C (170.6°F)    
    11°C (51.8°F) (Methanol)
    These products are toxic carbon oxides (CO, CO2), halogenated compounds.
    Combustion Products
    WARNING: Highly toxic HCl gas is produced during combustion.
    Fire Hazards
    Not available.
    Explosion Hazards        Risks of explosion of the product in presence of mechanical impact: Not available.    
    Risks of explosion of the product in presence of static discharge: Not available.
    Fire Fighting Media        Flammable liquid.    
    SMALL FIRE: Use DRY chemical powder.
    and Instructions
    LARGE FIRE: Use alcohol foam, water spray or fog. Cool containing vessels with water jet in order to prevent pressure
    build-up, autoignition or explosion. Consult with local fire authorities before attempting large scale fire-fighting operations.

Section VI.        Accidental Release Measures    
    Spill Cleanup        Flammable material. Highly toxic material. Irritating material. This material is a reproductive effector. Carcinogenic material.    
    Hygroscopic material.
    Instructions
    Keep away from heat. Mechanical exhaust required. Stop leak if without risk. Absorb with DRY earth, sand or other
    non-combustible material. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce
    vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Consult federal, state, and/or local
    authorities for assistance on disposal.

Section VII. Handling and Storage
    FLAMMABLE. HIGHLY TOXIC. IRRITANT. REPRODUCTIVE EFFECTOR. CARCINOGEN. HYGROSCOPIC.
    Handling and Storage
    REFRIGERATE. Keep locked up. Keep away from heat. Mechanical exhaust required. Avoid excessive heat and light. DO
    Information
    NOT ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. If ingested, seek medical advice
    immediately and show the container or the label. Treat symptomatically and supportively.
    Always store away from incompatible compounds such as oxidizing agents, reducing agents, acids, alkalis (bases).

Section VIII. Exposure Controls/Personal Protection
    Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective
    Engineering Controls
    threshold limit value. Ensure that eyewash station and safety shower is proximal to the work-station location.
    Splash goggles. Lab coat. Vapor respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid
    Personal Protection
    inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
    product.
    Exposure Limits        This chemical is classified as a carcinogen. There is no acceptable exposure limit for a carcinogen.    
    Continued on Next Page
    1,2-Dibromo-3-chloropropane (1mg/ml in Methanol)
    [for Water Analysis]

Section IX.        Physical and Chemical Properties    
    Physical state @ 20°C        Liquid. (Clear, colorless.)        Solubility        Miscible with water, ethanol, ether,    
    benzene,
    2.08 (water=1)        ketones, and most other organic solvents.    
    Specific Gravity
    0.79 (water=1) (Methanol)
    Molecular Weight        C3H5Br2Cl = 236.33        Partition Coefficient        LOG Pow: 2.96    
    CH4O = 32.04 (Methanol)
    LOG Pow: -0.77 (Methanol)
    Boiling Point        200°C (392°F)        Vapor Pressure        0.58 mmHg (@ 20°C)    
    64°C (147.2°F) (Methanol)        97.68 mmHg (@ 20°C) (Methanol)    
    Melting Point        5°C (41°F)        Vapor Density        2.09 (Air = 1)    
    -98°C ( -144.4°F) (Methanol)        1.1 (Air = 1) (Methanol)    
    Refractive Index        1.55        Volatility        Not available.    
    1.329 (Methanol)
    Not available.        Not available.    
    Critical Temperature        Odor    
    Viscosity        Not available.        Taste        Not available.    

Section X.        Stability and Reactivity Data    

This material is stable if stored under proper conditions. (See Section VII for instructions)
    Stability
    Conditions of Instability        Avoid excessive heat and light. Hygroscopic; keep container tightly closed.    
    Incompatibilities
    Reactive with oxidizing agents, reducing agents, metals, acids, alkalis (bases), magnesium.

Section XI. Toxicological Information
    TX8750000
    RTECS Number
    PC1400000 (Methanol)
    Routes of Exposure        Eye Contact. Ingestion. Inhalation.    
    Rat LD50 (oral) 170 mg/kg
    Toxicity Data
    Rabbit LD50 (dermal) 1400 mg/kg
    Rat LD50 (inhalation) 98 mg/m3/4H
    (Methanol)
    Rat LD50 (oral) 5600 mg/kg
    Rabbit LD50 (dermal) 15800 mg/kg
    Rat LD50 (inhalation) 6400 ppm/4H
    Chronic Toxic Effects        CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria.    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Tumorigenic effects.
    Rat TC Inhalation 600 ppb/6H for 76 weeks intermittent
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Sense Organs and Special Senses - Tumors
    Endocrine - Adrenal cortex tumors
    Rat TD Oral 9280 mg/kg for 64 weeks intermittent
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Gastrointestinal - Tumors
    Skin and Appendages - Tumors
    Rat TD Subcutaneous 240 mg/kg for 12 weeks intermittent
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Kidney, Ureter, and Bladder - Kidney tumors
    DEVELOPMENTAL TOXICITY: Reproductive effects.
    Rat TDLo Oral 375 mg/kg, male 75 days prior to mating
    Toxic Effects:
    Paternal Effects - Spermatogenesis
    Paternal Effects - Testes, epididymis, sperm duct
    Effects on Fertility - Male fertility index
    Rat TDLo Oral 250 mg/kg, male 5 days prior to mating
    Toxic Effects:
    Effects on Fertility - Post-implantation mortality
    Effects on Fertility - Litter size
    Rat TDLo Unreported 150 mg/kg, female 14-19 days of pregnancy
    Toxic Effects:
    Specific Developmental Abnormalities - Endocrine system
    Effects on Newborn - Growth statistics
    Effects on Newborn - Delayed effects
    DEVELOPMENTAL TOXICITY: Reproductive effects. (Methanol)
    Rat TCLo Inhalation 20000 ppm for 7 hours, female 1-22 days of pregnancy
    TOXIC EFFECTS:
    Specific Developmental Abnormalities – Musculoskeletal system
    Specific Developmental Abnormalities – Cardiovascular system
    Specific Developmental Abnormalities – Urogenital system
    Rat TDLo Oral 35295 mg/kg, female 1-15 days of pregnancy
    TOXIC EFFECTS:
    Effects on Fertility – Female fertility index
    Effects on Fertility – Pre-implantation mortality
    Continued on Next Page
    1,2-Dibromo-3-chloropropane (1mg/ml in Methanol)
    [for Water Analysis]
    Effects on Fertility – Post implantation mortality
    Mouse TDLo Oral 4 gm/kg, female 7 days of pregnancy
    TOXIC EFFECTS:
    Specific Developmental Abnormalities – Craniofacial
    Specific Developmental Abnormalities – Musculoskeletal system
    Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many
    human organs.
    Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
    Acute Toxic Effects
    Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye
    is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
    occasionally, blistering.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

Section XII.        Ecological Information    
    Ecotoxicity        Not available.    
    Environmental Fate        (1,2-Dibromo-3-chloropropane)    
    Due to the restrictions on the use of 1,2-dibromo-3-chloropropane as a nematocide and soil fumigant, little release of
    1,2-dibromo-3-chloropropane presently occurs. The use of 1,2-dibromo-3-chloropropane as a laboratory reactant is not
    expected to result in large quantities being released to the environment. If released to the atmosphere,
    1,2-dibromo-3-chloropropane will exist solely in the vapor phase in the ambient atmosphere, based on a measured vapor
    pressure of 0.58 mm Hg at 20 deg C. Vapor-phase 1,2-dibromo-3-chloropropane is degraded in the atmosphere by reaction
    with photochemically-produced hydroxyl radicals with an estimated half-life of about 37 days. Products of
    1,2-dibromopropanol, chlorobromopropanol, and 1-bromo-3-chloro-2-propanone are formed during this process.
    1,2-Dibromo-3-chloropropane released to soil will likely volatilize or leach. In alkaline, but not neutral or acidic soils, hydrolysis
    may be significant. Biodegradation is possible but is expected to be slow relative to volatilization and leaching. In water,
    1,2-dibromo-3-chloropropane is expected to volatilize. It may also slowly hydrolyze (half-life= 38 years, neutral pH, at 25 deg
    C). Estimated volatilization half-lives for a model river and model lake are 14 hours and 9 days, respectively. In groundwater,
    1,2-dibromo-3-chloropropane is expected to persist due to its low estimated rate of hydrolysis (half-life= 141 years, neutral pH,
    at 15 deg C). In surface waters, biodegradation may occur, but is expected to be slow relative to the rate of volatilization.
    Photodegradation is not expected to be an important fate process for this compound. Sorption to sediments and
    bioconcentration are not expected to be important fate processes based on measured Koc values of 40-149 and measured
    BCF values of 3.6-19, respectively. Human exposure is expected to result primarily from ingestion of drinking water,
    particularly from groundwater sources, containing 1,2-dibromo-3-chloropropane. Occupational exposure to
    1,2-dibromo-3-chloropropane is likely via inhalation and dermal contact with vapors, water, and products containing
    1,2-dibromo-3-chloro-propane.
    (Methanol)
    Methanol’s production and use as a solvent, fuel additive, and in the production of formaldehyde, acetic acid, and methyl
    tertiary butyl ether (MTBE) may result in its release to the environment through various waste streams. Methanol has been
    identified as a natural emission product from various plants and as a biological decomposition product of biological wastes
    and sewage. If released to the atmosphere, a vapor pressure of 127 mm Hg at 25 deg C indicates that methanol will exist
    solely in the vapor phase. Vapor phase methanol is degraded in the atmosphere by reaction with photochemically-produced
    hydroxyl radicals; the half-life for this reaction in air is estimated to be 17 days. If released to soil, methanol is expected to
    have very high mobility based upon an estimated Koc of 1. Volatilization from moist soil surfaces is expected to be an
    important fate process based upon a Henry’s Law constant of 4.55X10-6 atm-cu m/mole. Methanol may also volatilize from
    dry soils based upon it vapor pressure. Biodegradation of methanol in soils is expected to occur rapidly based on half-lives in
    a sandy silt loam from Texas and a sandy loam from Mississippi of 1 and 3.2 days, respectively. If released into water,
    methanol is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from
    water surfaces is expected to be an important fate process based upon this compound’s Henry’s Law constant. Estimated
    volatilization half-lives for a model river and model lake are 3 and 35 days, respectively. Biodegradation is expected to occur
    in natural waters since methanol is degraded quickly in soils and was biodegraded rapidly in various aqueous screening tests
    using sewage seed or activated sludge. BCF values of less than 10, measured in fish suggests bioconcentration in aquatic
    organisms is low. Hydrolysis of methanol and photolysis in sunlit surface waters are not expected since methanol lacks
    functional groups that are susceptible to hydrolysis or photolysis under environmental conditions. Occupational exposure to
    methanol may occur through inhalation and dermal contact with this compound at workplaces where methanol is produced or
    used. Monitoring data indicate that the general population may be exposed to methanol via inhalation of ambient air, and
    ingestion of food and drinking water.

Section XIII. Disposal Considerations
    Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
    Waste Disposal
    combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
    federal, state and local regulations when disposing of the substance.

Section XIV. Transport Information
    DOT Classification        DOT CLASS 3: Flammable liquid    
    DOT CLASS 6.1: Toxic material
    PIN Number
    Proper Shipping Name        Methanol solution    
    II
    Packing Group (PG)
    DOT Pictograms
    Continued on Next Page
    1,2-Dibromo-3-chloropropane (1mg/ml in Methanol)
    [for Water Analysis]

Section XV. Other Regulatory Information and Pictograms
    TSCA Chemical Inventory        This compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list.    
    (EPA)
    WHMIS Classification        CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).    
    CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
    (Canada)
    CLASS D-2B: Material causing other toxic effects (TOXIC).
    On NDSL.
    On DSL. (Methanol)
    EINECS Number (EEC)        202-479-3    
    200-659-6 (Methanol)
    EEC Risk Statements        R11- Highly flammable.    
    R18- In use, may form flammable/explosive vapor-air mixture.
    R26/27/28- Very toxic by inhalation, in contact with skin and if swallowed.
    R36/37/38- Irritating to eyes, respiratory system and skin.
    R45- May cause cancer.
    R60- May impair fertility.
    R61- May cause harm to the unborn child.
    Japanese Regulatory Data        ENCS No. 2-82    


SECTION 16 - ADDITIONAL INFORMATION
N/A

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