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N-(Hydroxymethyl)acrylamide
CAS No.: 924-42-5
Synonyms:
Formula: C4H7NO2
Exact Mass: 101.04800
Molecular Weight: 101.10400
PSA: 49.33000
LogP: -0.37070
Reference Price: $2,016/ton Inquiry Now
N-(Hydroxymethyl)acrylamide 924-42-5 MSDS

Section I.Chemical Product and Company Identification
    Chemical Name N-(Hydroxymethyl)acrylamide
    Portland OR
    Synonym        N-Methylolacrylamide    
    Chemical Formula        C4H7NO2    
    924-42-5
    CAS Number

Section II.        Composition and Information on Ingredients    
    Toxicology Data
    Chemical Name        CAS Number Percent (%)        TLV/PEL    
    N-(Hydroxymethyl)acrylamide        This chemical is classified as        Rat LD50 (oral) 474 mg/kg    
    924-42-5        Min.    
    98.0%(Tit.)        a carcinogen. There is no        Mouse LD50 (oral) 420 mg/kg    
    acceptable exposure limit for a        Rat LD50 (intraperitoneal) 563    
    carcinogen.        mg/kg    

Section III. Hazards Identification
    Acute Health Effects        Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or    
    death.
    Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
    eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening,
    or, occasionally, blistering.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
    CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria
    Chronic Health Effects
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : TUMORIGENIC EFFECTS
    Mouse TDLo Oral; 25750 mg/kg/103 weeks intermittent
    TOXIC EFFECTS
    Tumorigenic - Carcinogenic by RTECS criteria
    Liver - Tumors
    TDLo Oral; 12875 mg/kg/103 weeks intermittent
    TOXIC EFFECTS
    Tumorigenic - Carcinogenic by RTECS criteria
    Endocrine - Tumors
    TDLo Oral; 25750 mg/kg/2 years continuous
    TOXIC EFFECTS
    Tumorigenic - Carcinogenic by RTECS criteria
    Lung, Thorax, or Respiration - Tumors
    Liver - Tumors
    DEVELOPMENTAL TOXICITY: REPRODUCTIVE EFFECTS
    Mouse TDLo Oral; 730 gm/kg; male 6 weeks prior to mating
    TOXIC EFFECTS
    Paternal Effects - Spermatogenesis (including genetic material, sperm morphology, motility, and count)
    Paternal Effects - Testes, epididymis, sperm duct
    Effects on Fertility - Post-implantation mortility (e.g., dead and or resorbed implants per total number of implants)
    TDLo Oral; 15.6 mg/kg; female multigenerations
    TOXIC EFFECTS
    Effects on Newborn - Live birth index (similar to T26, except measured after birth)
    Effects on Newborn - Growth statistics (e.g., reduced weight gain)
    Effects on Newborn - Behavioral
    TDLo Oral; 188.8 mg/kg; female multigenerations
    TOXIC EFFECTS
    Specific Developmental Abnormalities - Urogenital system
    Effects on Newborn - Growth statistics (e.g., reduced weight gain)
    Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or
    many human organs.
    Continued on Next Page
    N-(Hydroxymethyl)acrylamide

Section IV.        First Aid Measures    
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15    
    minutes. Get medical attention.
    Skin Contact        In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing    
    and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately.
    Inhalation        If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or    
    waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
    improve.
    Ingestion        INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.    
    Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
    resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the
    toxic material was ingested; the absence of such signs, however, is not conclusive.

Section V.        Fire and Explosion Data    
    Not available.
    May be combustible at high temperature.        Auto-Ignition    
    Flammability
    Flammable Limits
    Flash Points        Not available.    
    Not available.
    Combustion Products        These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2).    
    Fire Hazards
    Not available.
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards
    Risks of explosion of the product in presence of static discharge: Not available.
    Fire Fighting Media        SMALL FIRE: Use DRY chemical powder.    
    and Instructions        LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.    
    Consult with local fire authorities before attempting large scale fire-fighting operations.

Section VI.        Accidental Release Measures    
    Spill Cleanup        Toxic Material. Irritating Material. Carcinogenic Material. Light Sensitive Material.    
    Stop leak if without risk. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce
    Instructions
    vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all sources of ignition.
    Consult federal, state, and/or local authorities for assistance on disposal.

Section VII. Handling and Storage
    Handling and Storage        TOXIC. IRRITANT. CARCINOGEN. LIGHT SENSITIVE. REFRIGERATE. Keep locked up.. Keep away from heat.    
    Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool place. Avoid excessive
    Information
    heat and light. DO NOT ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice
    immediately and show the container or the label. Treat symptomatically and supportively.
    Always store away from incompatible compounds such as oxidizing agents.

Section VIII. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below    
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Personal Protection        Splash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid    
    inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling
    this product.
    Exposure Limits        This chemical is classified as a carcinogen. There is no acceptable exposure limit for a carcinogen.    

Section IX. Physical and Chemical Properties
    Solid. (White Crystalline Powder.)        Solubility    
    Physical state @ 20°C        Not available.    
    1.082 (water=1)
    Specific Gravity
    Molecular Weight        101.1        Partition Coefficient        Not available.    
    Boiling Point        Not available.        Vapor Pressure        Not applicable.    
    Melting Point        76°C (168.8°F)        Vapor Density        Not available.    
    1.412        Volatility        Not available.    
    Refractive Index
    Critical Temperature        Not available.        Odor        Not available.    
    Viscosity        Not available.        Taste        Not available.    
    Continued on Next Page
    N-(Hydroxymethyl)acrylamide

Section X.        Stability and Reactivity Data    
    Stability    
This material is stable if stored under proper conditions. (See Section VII for instructions)    
    Conditions of Instability        Avoid excessive heat and light.    
    Incompatibilities        Highly reactive with oxidizing agents.    

Section XI. Toxicological Information
    AS3600000
    RTECS Number
    Eye Contact. Ingestion. Inhalation.
    Routes of Exposure
    Toxicity Data        Rat LD50 (oral) 474 mg/kg    
    Mouse LD50 (oral) 420 mg/kg
    Rat LD50 (intraperitoneal) 563 mg/kg
    Chronic Toxic Effects        CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : TUMORIGENIC EFFECTS
    Mouse TDLo Oral; 25750 mg/kg/103 weeks intermittent
    TOXIC EFFECTS
    Tumorigenic - Carcinogenic by RTECS criteria
    Liver - Tumors
    TDLo Oral; 12875 mg/kg/103 weeks intermittent
    TOXIC EFFECTS
    Tumorigenic - Carcinogenic by RTECS criteria
    Endocrine - Tumors
    TDLo Oral; 25750 mg/kg/2 years continuous
    TOXIC EFFECTS
    Tumorigenic - Carcinogenic by RTECS criteria
    Lung, Thorax, or Respiration - Tumors
    Liver - Tumors
    DEVELOPMENTAL TOXICITY: REPRODUCTIVE EFFECTS
    Mouse TDLo Oral; 730 gm/kg; male 6 weeks prior to mating
    TOXIC EFFECTS
    Paternal Effects - Spermatogenesis (including genetic material, sperm morphology, motility, and count)
    Paternal Effects - Testes, epididymis, sperm duct
    Effects on Fertility - Post-implantation mortility (e.g., dead and or resorbed implants per total number of implants)
    TDLo Oral; 15.6 mg/kg; female multigenerations
    TOXIC EFFECTS
    Effects on Newborn - Live birth index (similar to T26, except measured after birth)
    Effects on Newborn - Growth statistics (e.g., reduced weight gain)
    Effects on Newborn - Behavioral
    TDLo Oral; 188.8 mg/kg; female multigenerations
    TOXIC EFFECTS
    Specific Developmental Abnormalities - Urogenital system
    Effects on Newborn - Growth statistics (e.g., reduced weight gain)
    Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or
    many human organs.
    Acute Toxic Effects        Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or    
    death.
    Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
    eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening,
    or, occasionally, blistering.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

Section XII.        Ecological Information    
    Ecotoxicity        Not available.    
    Environmental Fate        Not available.    

Section XIII. Disposal Considerations
    Waste Disposal        Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a    
    combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
    federal, state and local regulations when disposing of the substance.

Section XIV. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    Not applicable.
    PIN Number
    Proper Shipping Name        Not applicable.    
    Packing Group (PG)        Not applicable.    
    Continued on Next Page
    N-(Hydroxymethyl)acrylamide
    DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
    TSCA Chemical Inventory        This compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list.    
    (EPA)
    WHMIS Classification
    CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
    On DSL.
    (Canada)
    EINECS Number (EEC)        213-103-2    
    EEC Risk Statements
    R23/24/25- Toxic by inhalation, in contact with skin and if swallowed.
    R36/37/38- Irritating to eyes, respiratory system and skin.
    R45- May cause cancer.
    Japanese Regulatory Data


SECTION 16 - ADDITIONAL INFORMATION
N/A

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