2-nitroanisole 91-23-6 MSDS
Name: 2-Nitroanisole Material Safety Data Sheet
Synonym: 1-Methoxy-2-nitrobenzene; 2-Methoxynitrobenzene; ortho-Nitrobenzene methyl ether; 2-Nitromethoxybenzene; o-Nitrophenyl methyl ether
CAS: 91-23-6
Section 1 - Chemical Product   MSDS Name:2-Nitroanisole Material Safety Data Sheet
Synonym:1-Methoxy-2-nitrobenzene; 2-Methoxynitrobenzene; ortho-Nitrobenzene methyl ether; 2-Nitromethoxybenzene; o-Nitrophenyl methyl ether

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
91-23-6 2-Nitroanisole 99 202-052-1
Hazard Symbols: T
Risk Phrases: 22 45

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Harmful if swallowed. May cause cancer.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. No skin absorption data found. No data found on whether or not this chemical would be likely to cause an allergic skin reaction.
Ingestion:
May cause irritation of the digestive tract. Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed. Overexposure may cause methemoglobinemia.
Inhalation:
Effects may be delayed. May cause respiratory tract irritation.
Chronic:
Possible cancer hazard based on tests with laboratory animals.

Section 4 - FIRST AID MEASURES
  Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
For large fires, use water spray, fog, or alcohol-resistant foam.
For small fires, use dry chemical, carbon dioxide, halon, or water spray.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 91-23-6: Russia: 1 mg/m3 TWA CAS# 29191-53-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Color: clear brown yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: 0.0036 mm Hg @ 25 deg C
Viscosity: Not available.
Boiling Point: 273 deg C
Freezing/Melting Point: 9.4 deg C
Autoignition Temperature: 464 deg C ( 867.20 deg F)
Flash Point: 142 deg C ( 287.60 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Insoluble.
Specific Gravity/Density: 1.2500 g/cm3
Molecular Formula: C7H7NO3
Molecular Weight: 153.14

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 91-23-6: BZ8790000 CAS# 29191-53-5 unlisted.
LD50/LC50:
CAS# 91-23-6: Oral, mouse: LD50 = 1300 mg/kg; Oral, mouse: LD50 = 1300 mg/kg; Oral, rat: LD50 = 740 mg/kg; Oral, rat: LD50 = 760 mg/kg.
CAS# 29191-53-5.
Carcinogenicity:
2-Nitroanisole - California: carcinogen, initial date 10/1/92 NTP: Suspect carcinogen IARC: Group 2B carcinogen Nitro-methoxybenzene - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Water danger/protection: WGK2 Invertebrate toxicity: EC50 (24 hr) Daphnia magna 13 mg/l (nominal value) [Kuehn, R. et al Water Res.
1989, 23(4), 501-510]

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: NITROANISOLE, LIQUID
Hazard Class: 6.1
UN Number: 2730
Packing Group: III
IMO
Shipping Name: NITROANISOLES, LIQUID
Hazard Class: 6.1
UN Number: 2730
Packing Group: III
RID/ADR
Shipping Name: NITROANISOLE
Hazard Class: 6.1
UN Number: 2730
Packing group: III

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 45 May cause cancer.
R 22 Harmful if swallowed.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 91-23-6: 3
CAS# 29191-53-5: No information available.
Canada
CAS# 91-23-6 is listed on Canada's NDSL List.
CAS# 91-23-6 is listed on Canada's Ingredient Disclosure List.
CAS# 29191-53-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 91-23-6 is listed on the TSCA inventory.
CAS# 29191-53-5 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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