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Tobramycin sulphate
CAS No.: 79645-27-5
Formula: C18H39N5O13S
Exact Mass: 565.22700
Molecular Weight: 565.59300
PSA: 351.15000
LogP: -2.36630
Reference Price: $1,674/kg Inquiry Now
Tobramycin sulphate 79645-27-5 MSDS

Section 1. Chemical Product and Company Identification
    Tobramycin Sulfate
    Common Name/
    Trade Name
    Tobramycin Sulfate

Section 3. Hazards Identification
    Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
    Potential Acute Health
    CARCINOGENIC EFFECTS: Not available.
    Potential Chronic Health
    MUTAGENIC EFFECTS: Not available.
    TERATOGENIC EFFECTS: Not available.
    The substance may be toxic to kidneys, ears.
    Repeated or prolonged exposure to the substance can produce target organs damage.

Section 4. First Aid Measures
    Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
    Eye Contact
    15 minutes. Cold water may be used. Get medical attention if irritation occurs.
    Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
    Skin Contact
    Cold water may be used.
    Not available.
    Serious Skin Contact
    If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
    medical attention.
    Not available.
    Serious Inhalation
    Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
    unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms
    Not available.
    Serious Ingestion

Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Not available.
    Flash Points
    Not available.
    Flammable Limits
    These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
    Products of Combustion
    Fire Hazards in Presence of Slightly flammable to flammable in presence of open flames and sparks, of heat.
    Various Substances
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards in
    Risks of explosion of the product in presence of static discharge: Not available.
    Presence of Various
    SMALL FIRE: Use DRY chemical powder.
    Fire Fighting Media
    LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    and Instructions
    Not available.
    Special Remarks on
    Fire Hazards
    Not available.
    Special Remarks on
    Explosion Hazards
    Tobramycin Sulfate

Section 6. Accidental Release Measures
    Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading
    Small Spill
    water on the contaminated surface and dispose of according to local and regional authority requirements.
    Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on
    Large Spill
    the contaminated surface and allow to evacuate through the sanitary system.

Section 7. Handling and Storage
    Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
    ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label.
    Keep away from incompatibles such as oxidizing agents, acids.
    Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C (46.4°F).

Section 8. Exposure Controls/Personal Protection
    Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
    Engineering Controls
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
    Personal Protection
    Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to
    avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE
    of a Large Spill
    handling this product.
    Not available.
    Exposure Limits

Section 9. Physical and Chemical Properties
    Solid. (crystalline powder)        Not available.    
    Physical state and        O dor    
    Not available.
    467.51 g/mole
    Molecular Weight
    Not available.
    pH (1% soln/water)
    Not available.
    Boiling Point
    549°C (1020.2°F)
    Melting Point
    Not available.
    Critical Temperature
    Not available.
    Specific Gravity
    Not applicable.
    Vapor Pressure
    Not available.
    Vapor Density
    Not available.
    Not available.
    Odor Threshold
    Not available.
    Water/Oil Dist. Coeff.
    Not available.
    Ionicity (in Water)
    See solubility in water.
    Dispersion Properties
    Easily soluble in cold water.
    Tobramycin Sulfate

Section 10. Stability and Reactivity Data
    The product is stable.
    Not available.
    Instability Temperature
    Conditions of Instability Excess heat, incompatible materials
    Incompatibility with various Reactive with oxidizing agents, acids.
    Not available.
    Not available.
    Special Remarks on
    Not available.
    Special Remarks on
    Will not occur.

Section 11. Toxicological Information
    Inhalation. Ingestion.
    Routes of Entry
    Acute oral toxicity (LD50): 10500 mg/kg [Mouse].
    Toxicity to Animals
    Chronic Effects on Humans May cause damage to the following organs: kidneys, ears.
    Other Toxic Effects on        Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.    
    Not available.
    Special Remarks on
    Toxicity to Animals
    May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data.
    Special Remarks on
    Chronic Effects on Humans
    Special Remarks on other        Acute Potential Health Effects:    
    Toxic Effects on Humans        Skin: May cause skin irritation.    
    Eyes: May cause eye irritation.
    Inhalation: May cause respiratory tract irritation.
    Ingestion: May cause nausea, vomiting, increased thirst, loss of appetite. May affect behavior/central nervous
    system/nervous system (wakefulness, hallucinations, convulsions, muscle twitching, numbness, seizures, tingling,
    dizziness, unsteadiness, clumsiness, headache), respiration (dyspnea). May also cause skin itching, redness, rash, or
    Chronic Potential Health Effects:
    Ingestion: Prololnged or repeated ingestion may cause weight loss, affect kidneys (acute renal failure, acute tubular
    necrosis), endocrine system (adrenal gland), ears (change in cochlear structure or function, auditory ototoxicity (any
    hearing loss, high-pitched ringing or buzzing or feeling of fullness in ears), vestibular ototoxicity (clumsiness ,dizziness
    ,nausea, vomiting, unsteadiness)), and have symptoms similar to acute ingestion.

Section 12. Ecological Information
    Not available.
    Not available.
    BOD5 and COD
    Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
    The product itself and its products of degradation are not toxic.
    Toxicity of the Products
    of Biodegradation
    Not available.
    Special Remarks on the
    Products of Biodegradation
    Tobramycin Sulfate

Section 13. Disposal Considerations
    Waste Disposal

Section 14. Transport Information
    Not a DOT controlled material (United States).
    DO T Cl assi fi cati on
    Not applicable.
    Not applicable.
    Special Provisions for
    DO T (Pi ctograms)

Section 15. Other Regulatory Information and Pictograms
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    Federal and State
    cause cancer, birth defects or other reproductive harm, which would require a warning under the statute: Tobramycin
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause birth defects which would require a warning under the statute: Tobramycin Sulfate
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause cancer which would require a warning under the statute: No products were found.
    Proposition 65
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause birth defects which would require a warning under the statute: Tobramycin Sulfate
    OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
    Other Regulations
    EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
    WHMIS (Canada) Not controlled under WHMIS (Canada).
    Other Classifications
    This product is not classified according Not applicable.
    DSCL (EEC)
    to the EU regulations.
    HMIS (U.S.A.)        Health Hazard        1 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    1 0 Reactivity
    Specific hazard
    Personal Protection
    WHMIS (Canada)
    DSCL (Europe)
    Tobramycin Sulfate
    ADR (Europe)
    Protective Equipment
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or equivalent.


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