CAS No.: 79-06-1
Formula: C3H5NO
Exact Mass: 71.03710
Molecular Weight: 71.07790
PSA: 43.09000
LogP: 0.35800
acrylamide 79-06-1 MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Acrylamide    
    REACH No.        : 01-2119463260-48-XXXX    
    CAS-No.        : 79-06-1    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Carcinogenicity (Category 1B), H350
    Germ cell mutagenicity (Category 1B), H340
    Reproductive toxicity (Category 2), H361f
    Acute toxicity, Oral (Category 3), H301
    Specific target organ toxicity - repeated exposure (Category 1), H372
    Acute toxicity, Inhalation (Category 4), H332
    Acute toxicity, Dermal (Category 4), H312
    Eye irritation (Category 2), H319
    Skin irritation (Category 2), H315
    Skin sensitisation (Category 1), H317
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    T Toxic        R25, R48/23/24/25    
    Xn Harmful        R20/21    
    Xi Irritant        R36/38    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Signal word        Danger    
    Hazard statement(s)
    H301        Toxic if swallowed.    
    H312 + H332        Harmful in contact with skin or if inhaled    
    H315        Causes skin irritation.    
    H317        May cause an allergic skin reaction.    
    H319        Causes serious eye irritation.    
    H340        May cause genetic defects.    
    H350        May cause cancer.    
    H361f        Suspected of damaging fertility.    
    H372        Causes damage to organs through prolonged or repeated exposure.    
    Precautionary statement(s)
    P201        Obtain special instructions before use.    
    P280        Wear protective gloves/ protective clothing.    
    P301 + P310        IF SWALLOWED: Immediately call a POISON CENTER or doctor/    
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    P308 + P313        IF exposed or concerned: Get medical advice/ attention.    
    Supplemental Hazard        none    
    Restricted to professional users.
  Other hazards - none

SECTION 3: Composition/information on ingredients
    Synonyms        : Acrylic acid amide    
    Formula        : C3H5NO    
    Molecular Weight        : 71,08 g/mol    
    CAS-No.        : 79-06-1    
    EC-No.        : 201-173-7    
    Registration number        : 01-2119463260-48-XXXX    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  Acrylamide Included in the Candidate List of Substances of Very High Concern (SVHC) according to
    Regulation (EC) No. 1907/2006 (REACH)
    CAS-No.        79-06-1        Carc. 1B; Muta. 1B; Repr. 2; <= 100 %    
    EC-No.        201-173-7        Acute Tox. 3; STOT RE 1;    
    Index-No.        616-003-00-0        Acute Tox. 4; Eye Irrit. 2; Skin    
    Registration number 01-2119463260-48-XXXX Irrit. 2; Skin Sens. 1; H372,
    H319, H315, H301, H312,
    H317, H332, H340, H350,
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  Acrylamide Included in the Candidate List of Substances of Very High Concern (SVHC) according to
    Regulation (EC) No. 1907/2006 (REACH)
    CAS-No.        79-06-1        T, Carc.Cat.2, Mut.Cat.2,        <= 100 %    
    EC-No.        201-173-7        Repr.Cat.3, R45 - R46 -    
    Index-No.        616-003-00-0        R20/21 - R25 - R36/38 - R43 -    
    Registration number 01-2119463260-48-XXXX R48/23/24/25 - R62
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides, nitrogen oxides (NOx)
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    no data available

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
    adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
    environment must be avoided.
  Methods and materials for containment and cleaning up
    Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
    containers for disposal.
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Avoid exposure - obtain special
    instructions before use.
    Provide appropriate exhaust ventilation at places where dust is formed.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
    Light sensitive.
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
    the product.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Full contact
    Material: Nitrile rubber
    Minimum layer thickness: 0,11 mm
    Break through time: 480 min
    Material tested:Dermatril® (KCL 740 / Z677272, Size M)
    Splash contact
    Material: Nitrile rubber
    Minimum layer thickness: 0,11 mm
    Break through time: 480 min
    Material tested:Dermatril® (KCL 740 / Z677272, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    Complete suit protecting against chemicals, The type of protective equipment must be selected
    according to the concentration and amount of the dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face particle
    respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering
    controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use
    respirators and components tested and approved under appropriate government standards such
    as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
    the environment must be avoided.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: powder    
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        5,2 - 6 at 500 g/l    
    e) Melting point/freezing        Melting point/range: 82 - 86 °C - lit.    
    f) Initial boiling point and 125 °C at 33 hPa - lit.
    boiling range
    g) Flash point        138 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        no data available    
    flammability or
    explosive limits
    k) Vapour pressure        2,1 hPa at 84,50 °C    
    0,04 hPa at 40 °C
    0,0900 hPa at 25 °C
    l) Vapour density        2,45 - (Air = 1.0)    
    m) Relative density        no data available    
    n) Water solubility        200 g/l at 20 °C    
    o) Partition coefficient: n- log Pow: -0,67
    p) Auto-ignition        no data available    
    q) Decomposition        no data available    
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    Relative vapour density 2,45 - (Air = 1.0)

SECTION 10: Stability and reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    no data available
  Incompatible materials
    Acids, Oxidizing agents, Iron and iron salts., Copper, Brass, Free radical initiators
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LD50 Oral - rat - 177 mg/kg
    LC50 Inhalation - rat - 4 h - > 1.500 mg/m3
    LD50 Dermal - rabbit - 1.141 mg/kg
    (OECD Test Guideline 402)
  Skin corrosion/irritation
    Skin - rabbit
    Result: No skin irritation
    (OECD Test Guideline 404)
    Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
  Serious eye damage/eye irritation
    Eyes - rabbit
    Result: Irritating to eyes.
    (OECD Test Guideline 405)
  Respiratory or skin sensitisation
    Maximisation Test - guinea pig
    May cause allergic skin reaction.
    (OECD Test Guideline 406)
  Germ cell mutagenicity
    May alter genetic material. In vivo tests showed mutagenic effects
    This product is or contains a component that has been reported to be probably carcinogenic based on its
    IARC, OSHA, ACGIH, NTP, or EPA classification. Possible human carcinogen
    IARC:        2A - Group 2A: Probably carcinogenic to humans (Acrylamide)    
  Reproductive toxicity
    Animal testing did not show any effects on foetal development.
    May cause reproductive disorders. Suspected human reproductive toxicant
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    Oral - Causes damage to organs through prolonged or repeated exposure. - Peripheral nervous system
  Aspiration hazard
    no data available
  Additional Information
    RTECS: AS3325000
    Liver - Irregularities - Based on Human Evidence

SECTION 12: Ecological information
    Toxicity to fish        LC50 - Pimephales promelas (fathead minnow) - 90 mg/l - 96 h    
    NOEC - Cyprinus carpio (Carp) - 5 mg/l - 28 d
    Toxicity to daphnia and mortality NOEC - Daphnia magna (Water flea) - 60 mg/l - 48 h
    other aquatic
    EC50 - Daphnia magna (Water flea) - 160 mg/l - 48 h
  Persistence and degradability
    Biodegradability        Result: 100 % - Readily biodegradable.    
    (OECD Test Guideline 301D)
  Bioaccumulative potential
    Bioaccumulation        Oncorhynchus mykiss (rainbow trout) - 72 h    
    - 710 µg/l
    Bioconcentration factor (BCF): 1,65
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    Harmful to aquatic life.
    no data available

SECTION 13: Disposal considerations
  Waste treatment methods
    Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
    with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 2074        IMDG: 2074        IATA: 2074    
  UN proper shipping name
    IATA:        Acrylamide, solid    
  Transport hazard class(es)
    ADR/RID: 6.1        IMDG: 6.1        IATA: 6.1    
  Packaging group
    ADR/RID: III        IMDG: III        IATA: III    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available



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