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CAS No.: 71-43-2
Formula: C6H6
Exact Mass: 78.04700
Molecular Weight: 78.11180
PSA: 0.00000
LogP: 1.68660
Reference Price: $737/ton Inquiry Now
benzene 71-43-2 MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Benzene    
    REACH No.        : 01-2119447106-44-XXXX    
    CAS-No.        : 71-43-2    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Flammable liquids (Category 2), H225
    Carcinogenicity (Category 1A), H350
    Germ cell mutagenicity (Category 1B), H340
    Specific target organ toxicity - repeated exposure (Category 1), H372
    Aspiration hazard (Category 1), H304
    Eye irritation (Category 2), H319
    Skin irritation (Category 2), H315
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    F Highly flammable        R11    
    T Toxic        R48/23/24/25    
    Xn Harmful        R65    
    Xi Irritant        R36/38    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Signal word        Danger    
    Hazard statement(s)
    H225        Highly flammable liquid and vapour.    
    H304        May be fatal if swallowed and enters airways.    
    H315        Causes skin irritation.    
    H319        Causes serious eye irritation.    
    H340        May cause genetic defects.    
    H350        May cause cancer.    
    H372        Causes damage to organs through prolonged or repeated exposure.    
    Precautionary statement(s)
    P201        Obtain special instructions before use.    
    P210        Keep away from heat/sparks/open flames/hot surfaces. - No smoking.    
    P301 + P310        IF SWALLOWED: Immediately call a POISON CENTER or doctor/    
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    P308 + P313        IF exposed or concerned: Get medical advice/ attention.    
    P331        Do NOT induce vomiting.    
    Supplemental Hazard        none    
    Restricted to professional users.
  Other hazards - none

SECTION 3: Composition/information on ingredients
    Formula        : C6H6    
    Molecular Weight        : 78,11 g/mol    
    CAS-No.        : 71-43-2    
    EC-No.        : 200-753-7    
    Registration number        : 01-2119447106-44-XXXX    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
    CAS-No.        71-43-2        Flam. Liq. 2; Skin Irrit. 2; Eye        <= 100 %    
    EC-No.        200-753-7        Irrit. 2; Muta. 1B; Carc. 1A;    
    Index-No.        601-020-00-8        STOT RE 1; Asp. Tox. 1;    
    Registration number        01-2119447106-44-XXXX        H225, H304, H315, H319,    
    H340, H350, H372
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
    CAS-No.        71-43-2        F, T, Carc.Cat.1, Mut.Cat.2,        <= 100 %    
    EC-No.        200-753-7        R45 - R46 - R11 - R36/38 -    
    Index-No.        601-020-00-8        R48/23/24/25 - R65    
    Registration number        01-2119447106-44-XXXX    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides
    Flash back possible over considerable distance., Container explosion may occur under fire conditions.
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
    Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
    form explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
    environment must be avoided.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13).
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation
    of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Full contact
    Material: Fluorinated rubber
    Minimum layer thickness: 0,7 mm
    Break through time: 480 min
    Material tested:Vitoject® (KCL 890 / Z677698, Size M)
    Splash contact
    Material: Fluorinated rubber
    Minimum layer thickness: 0,7 mm
    Break through time: 480 min
    Material tested:Vitoject® (KCL 890 / Z677698, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type
    of protective equipment must be selected according to the concentration and amount of the
    dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
    the environment must be avoided.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: liquid    
    Colour: colourless
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        Melting point/range: 5,5 °C - lit.    
    f) Initial boiling point and 80 °C - lit.
    boiling range
    g) Flash point        -11,0 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        Upper explosion limit: 8 %(V)    
    flammability or        Lower explosion limit: 1,3 %(V)    
    explosive limits
    k) Vapour pressure        221,3 hPa at 37,7 °C    
    99,5 hPa at 20,0 °C
    l) Vapour density        no data available    
    m) Relative density        0,874 g/cm3 at 25 °C    
    n) Water solubility        no data available    
    o) Partition coefficient: n- no data available
    p) Auto-ignition        562,0 °C    
    q) Decomposition        no data available    
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    no data available

SECTION 10: Stability and reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Heat, flames and sparks. Extremes of temperature and direct sunlight.
  Incompatible materials
    acids, Bases, Halogens, Strong oxidizing agents, Metallic salts
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LD50 Oral - rat - 2.990 mg/kg
    LC50 Inhalation - rat - female - 4 h - 44.700 mg/m3
    LD50 Dermal - rabbit - 8.263 mg/kg
  Skin corrosion/irritation
    Skin - rabbit
    Result: Skin irritation
  Serious eye damage/eye irritation
    Eyes - rabbit
    Result: Eye irritation
  Respiratory or skin sensitisation
    no data available
  Germ cell mutagenicity
    Laboratory experiments have shown mutagenic effects.
    In vivo tests showed mutagenic effects
    Sister chromatid exchange
    Mutation in mammalian somatic cells.
    Sister chromatid exchange
    Carcinogenicity - Human - male - Inhalation
    Tumorigenic:Carcinogenic by RTECS criteria. Leukaemia Blood:Thrombocytopenia.
    Carcinogenicity - rat - Oral
    Tumorigenic:Carcinogenic by RTECS criteria. Endocrine:Tumors. Leukaemia
    This is or contains a component that has been reported to be carcinogenic based on its IARC, OSHA,
    ACGIH, NTP, or EPA classification.
    Human carcinogen.
    IARC:        1 - Group 1: Carcinogenic to humans (Benzene)    
  Reproductive toxicity
    Reproductive toxicity - mouse - Intraperitoneal
    Effects on Fertility: Pre-implantation mortality (e.g., reduction in number of implants per female; total
    number of implants per corpora lutea). Effects on Embryo or Fetus: Fetal death.
    Developmental Toxicity - rat - Inhalation
    Effects on Embryo or Fetus: Extra embryonic structures (e.g., placenta, umbilical cord). Effects on Embryo
    or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
    Developmental Toxicity - mouse - Inhalation
    Effects on Embryo or Fetus: Cytological changes (including somatic cell genetic material). Specific
    Developmental Abnormalities: Blood and lymphatic system (including spleen and marrow).
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    May be fatal if swallowed and enters airways.
  Additional Information
    RTECS: CY1400000
    Nausea, Dizziness, Headache, narcosis, Inhalation of high concentrations of benzene may have an initial
    stimulatory effect on the central nervous system characterized by exhilaration, nervous excitation and/or
    giddiness, depression, drowsiness, or fatigue. The victim may experience tightness in the chest,
    breathlessness, and loss of consciousness. Tremors, convulsions, and death due to respiratory paralysis
    or circulatory collapse can occur in a few minutes to several hours following severe exposures. Aspiration
    of small amounts of liquid immediately causes pulmonary edema and hemorrhage of pulmonary tissue.
    Direct skin contact may cause erythema. Repeated or prolonged skin contact may result in drying, scaling
    dermatitis, or development of secondary skin infections. The chief target organ is the hematopoietic
    system. Bleeding from the nose, gums, or mucous membranes and the development of purpuric spots,
    pancytopenia, leukopenia, thrombocytopenia, aplastic anemia, and leukemia may occur as the condition
    progresses. The bone marrow may appear normal, aplastic or hyperplastic, and may not correlate with
    peripheral blood-forming tissues. The onset of effects of prolonged benzene exposure may be delayed for
    many months or years after the actual exposure has ceased., Blood disorders

SECTION 12: Ecological information
    Toxicity to fish        LC50 - Oncorhynchus mykiss (rainbow trout) - 5,90 mg/l - 96 h    
    LC50 - Pimephales promelas (fathead minnow) - 15,00 - 32,00 mg/l - 96 h
    LC50 - Lepomis macrochirus (Bluegill) - 230,00 mg/l - 96 h
    NOEC - Pimephales promelas (fathead minnow) - 10,2 mg/l - 7 d
    LOEC - Pimephales promelas (fathead minnow) - 17,2 mg/l - 7 d
    Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 22,00 mg/l - 48 h
    other aquatic
    EC50 - Daphnia magna (Water flea) - 9,20 mg/l - 48 h
    Toxicity to algae        EC50 - Pseudokirchneriella subcapitata (green algae) - 29,00 mg/l - 72 h    
  Persistence and degradability
    Biodegradability        Result: - Readily biodegradable.    
  Bioaccumulative potential
    Bioaccumulation        Leuciscus idus (Golden orfe) - 3 d    
    - 0,05 mg/l
    Bioconcentration factor (BCF): 10
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    Toxic to aquatic life.

SECTION 13: Disposal considerations
  Waste treatment methods
    Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
    as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 1114        IMDG: 1114        IATA: 1114    
  UN proper shipping name
    IATA:        Benzene    
  Transport hazard class(es)
    ADR/RID: 3        IMDG: 3        IATA: 3    
  Packaging group
    ADR/RID: II        IMDG: II        IATA: II    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available



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