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norfloxacin 70458-96-7 MSDS

Section I.Chemical Product and Company Identification
    Chemical Name Norfloxacin
    Portland OR
    Synonym        3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-    
    dihydro-4-oxo-7-(1-piperazinyl)- (CA INDEX NAME);
    1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
    3-quinolinecarboxylic Acid
    Chemical Formula        C16H18FN3O3    
    CAS Number        70458-96-7    

Section II.        Composition and Information on Ingredients    
    Toxicology Data
    Chemical Name        CAS Number Percent (%)        TLV/PEL    
    Min. 98.0 Not available.        Rat LD50 (oral) >4 gm/kg    
    Norfloxacin        70458-96-7    
    (HPLC,T)        Mouse LD50 (intraperitoneal) 1064    
    mg/kg
    Rat LD50 (intravenous) 245 mg/kg

Section III. Hazards Identification
    No specific information is available in our data base regarding the toxic effects of this material for humans. However,
    Acute Health Effects
    exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
    inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling
    this compound.
    CARCINOGENIC EFFECTS : Not available.
    Chronic Health Effects
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Not available.
    DEVELOPMENTAL TOXICITY: Reproductive effects.
    Rat TDLo Oral 1375 mg/kg, female 7-17 days of pregnancy
    Toxic Effects:
    Specific Developmental Abnormalities - Musculoskeletal system
    Effects on Newborn - Behavioral
    Rabbit Oral 1300 mg/kg, female 6-18 days of pregnancy
    Toxic Effects:
    Effects on Fertility - Litter size
    Effects on Embryo or Fetus - Fetotoxicity
    Effects on Embryo or Fetus - Fetal death
    Rabbit Oral 1625 mg/kg, female 13 days prior to mating
    Toxic Effects:
    Maternal Effects - Ovaries, fallopian tubes
    Maternal Effects - Uterus, cervix, vagina
    Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.

Section IV.        First Aid Measures    
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15    
    minutes. Get medical attention.
    Skin Contact        In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing    
    before reuse. Thoroughly clean shoes before reuse. Get medical attention.
    Inhalation        If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or    
    waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
    improve.
    INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
    Ingestion
    Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
    resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
    material was ingested; the absence of such signs, however, is not conclusive.
    Continued on Next Page
    Norfloxacin

Section V.        Fire and Explosion Data    
    Not available.
    Flammability        May be combustible at high temperature.        Auto-Ignition    
    Flammable Limits        Not available.    
    Flash Points        Not available.    
    Combustion Products        These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), halogenated compounds.    
    WARNING: Highly toxic HF gas is produced during combustion.
    Fire Hazards        Not available.    
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards
    Risks of explosion of the product in presence of static discharge: Not available.
    Fire Fighting Media
    SMALL FIRE: Use DRY chemical powder.
    LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
    and Instructions
    Consult with local fire authorities before attempting large scale fire-fighting operations.

Section VI.        Accidental Release Measures    
    Spill Cleanup        Hygroscopic material.    
    Use a shovel to put the material into a convenient waste disposal container. Finish cleaning the spill by rinsing any
    Instructions
    contaminated surfaces with copious amounts of water. Consult federal, state, and/or local authorities for assistance on
    disposal.

Section VII. Handling and Storage
    HYGROSCOPIC. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store
    Handling and Storage
    in a dry, cool place. Avoid excessive heat and light. Do not breathe dust.
    Information
    Always store away from incompatible compounds such as oxidizing agents, moisture.

Section VIII. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended    
    exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
    below the exposure limit.
    Personal Protection        Splash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a    
    specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
    Not available.
    Exposure Limits

Section IX. Physical and Chemical Properties
    Physical state @ 20°C        Solid. (Very pale yellow ~ pale yellow,        Solubility        Solubility at 25°C (mg/ml): water 0.28;    
    crystal ~ powder.)
    methanol 0.98; ethanol 1.9; acetone 5.1;
    chloroform 5.5; diethyl ether 0.1; benzene
    Not available.
    Specific Gravity
    0.15; ethyl acetate 0.94; octyl alcohol 5.1;
    glacial acetic acid 340.
    Solubility in water is pH dependent,
    increasing sharply at pH <5 or at pH >10.
    Molecular Weight        319.33        Partition Coefficient        LOG Pow: 0.46    
    Boiling Point        Not available.        Not applicable.    
    Vapor Pressure
    Melting Point        221°C (429.8°F)        Vapor Density        Not available.    
    Not available.        Not available.    
    Refractive Index        Volatility    
    Critical Temperature        Not available.        Odor        Not available.    
    Not available.        Not available.    
    Viscosity        Taste    

Section X.        Stability and Reactivity Data    

This material is stable if stored under proper conditions. (See Section VII for instructions)
    Stability
    Conditions of Instability        Avoid excessive heat and light. Hygroscopic; keep container tightly closed.    
    Incompatibilities        Reactive with oxidizing agents, moisture.    
    Continued on Next Page
    Norfloxacin

Section XI. Toxicological Information
    RTECS Number        VB2005000    
    Eye Contact. Ingestion. Inhalation.
    Routes of Exposure
    Toxicity Data        Rat LD50 (oral) >4 gm/kg    
    Mouse LD50 (intraperitoneal) 1064 mg/kg
    Rat LD50 (intravenous) 245 mg/kg
    Chronic Toxic Effects        CARCINOGENIC EFFECTS : Not available.    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Not available.
    DEVELOPMENTAL TOXICITY: Reproductive effects.
    Rat TDLo Oral 1375 mg/kg, female 7-17 days of pregnancy
    Toxic Effects:
    Specific Developmental Abnormalities - Musculoskeletal system
    Effects on Newborn - Behavioral
    Rabbit Oral 1300 mg/kg, female 6-18 days of pregnancy
    Toxic Effects:
    Effects on Fertility - Litter size
    Effects on Embryo or Fetus - Fetotoxicity
    Effects on Embryo or Fetus - Fetal death
    Rabbit Oral 1625 mg/kg, female 13 days prior to mating
    Toxic Effects:
    Maternal Effects - Ovaries, fallopian tubes
    Maternal Effects - Uterus, cervix, vagina
    Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
    Acute Toxic Effects        No specific information is available in our data base regarding the toxic effects of this material for humans. However,    
    exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
    inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling this
    compound.

Section XII.        Ecological Information    
    Not available.
    Ecotoxicity
    Not available.
    Environmental Fate

Section XIII. Disposal Considerations
    Waste Disposal        Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a    
    combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
    federal, state and local regulations when disposing of the substance.

Section XIV. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    PIN Number        Not applicable.    
    Proper Shipping Name        Not applicable.    
    Packing Group (PG)        Not applicable.    
    DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
    TSCA Chemical Inventory        This product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40    
    CFR 720.36 (C) for those products not on the inventory list:
    (EPA)
    (i) These products are supplied solely for use in research and development by or under the supervision of a technically
    qualified individual as defined in 40 CFR 720.0 et sec.
    (ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
    supplied on an MSDS sheet.
    WHMIS Classification        On DSL.    
    (Canada)
    EINECS Number (EEC) 274-614-4
    EEC Risk Statements        Not available.    
    Japanese Regulatory Data Not available.
    Continued on Next Page


SECTION 16 - ADDITIONAL INFORMATION
N/A

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