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hexamethylphosphoric triamide 680-31-9 MSDS
Name: Hexamethylphosphoramide 99% Material Safety Data Sheet
Synonym: Hexametapol; Hexamethylphosphoric triamide; HEMPA; HMPA; Phosphoric acid hexamethyltriamide; Tris(dimethylamino)-phosphine oxide; Hexamethyl phosphoramide
CAS: 680-31-9
Section 1 - Chemical Product   MSDS Name:Hexamethylphosphoramide 99% Material Safety Data Sheet
Synonym:Hexametapol; Hexamethylphosphoric triamide; HEMPA; HMPA; Phosphoric acid hexamethyltriamide; Tris(dimethylamino)-phosphine oxide; Hexamethyl phosphoramide

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
680-31-9 Hexamethylphosphoramide 99 211-653-8
Hazard Symbols: T
Risk Phrases: 45 46

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
May cause cancer. May cause heritable genetic damage.Cancer suspect agent.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be absorbed through the skin in harmful amounts.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation.
Chronic:
Possible cancer hazard based on tests with laboratory animals.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Use only with adequate ventilation. Avoid breathing vapor or mist.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 680-31-9: Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Color: clear, colorless
Odor: amine-like
pH: Not available.
Vapor Pressure: 0.046 mm Hg @ 25 deg C
Viscosity: Not available.
Boiling Point: 233 deg C
Freezing/Melting Point: 7.2 deg C
Autoignition Temperature: 230 deg C ( 446.00 deg F)
Flash Point: 105 deg C ( 221.00 deg F)
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density: 1.0300 g/cm3
Molecular Formula: C6H18N3OP
Molecular Weight: 179.20

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, sodium, potassium.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of phosphorus, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 680-31-9: TD0875000 LD50/LC50:
CAS# 680-31-9: Dermal, guinea pig: LD50 = 1175 mg/kg; Oral, mouse: LD50 = 2400 mg/kg; Oral, rat: LD50 = 2650 mg/kg; Skin, rabbit: LD50 = 2600 mg/kg.
Carcinogenicity:
Hexamethylphosphoramide - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 1/1/88 NTP: Suspect carcinogen IARC: Group 2B carcinogen Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Other No information available.

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: NOT REGULATED
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: NOT REGULATED
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: NOT REGULATED
Hazard Class: 6.1
UN Number:
Packing group: I
USA RQ: CAS# 680-31-9: 1 lb final RQ; 0.454 kg final RQ

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 45 May cause cancer.
R 46 May cause heritable genetic damage.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 680-31-9: No information available.
Canada
CAS# 680-31-9 is listed on Canada's NDSL List.
CAS# 680-31-9 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 680-31-9 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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