N,N-dimethylformamide 68-12-2 MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : N,N-Dimethylformamide    
    REACH No.        : 01-2119475605-32-XXXX    
    CAS-No.        : 68-12-2    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Flammable liquids (Category 3), H226
    Acute toxicity, Inhalation (Category 4), H332
    Acute toxicity, Dermal (Category 4), H312
    Eye irritation (Category 2), H319
    Reproductive toxicity (Category 1B), H360D
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    Xn Harmful        R20/21    
    Xi Irritant        R36    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Signal word        Danger    
    Hazard statement(s)
    H226        Flammable liquid and vapour.    
    H312 + H332        Harmful in contact with skin or if inhaled    
    H319        Causes serious eye irritation.    
    H360D        May damage the unborn child.    
    Precautionary statement(s)
    P201        Obtain special instructions before use.    
    P280        Wear protective gloves/ protective clothing.    
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    P308 + P313        IF exposed or concerned: Get medical advice/ attention.    
    Supplemental Hazard        none    
    Restricted to professional users.
  Other hazards
    This substance/mixture contains no components considered to be either persistent, bioaccumulative and
    toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
    Rapidly absorbed through skin.

SECTION 3: Composition/information on ingredients
    Synonyms        : DMF    
    Formula        : C3H7NO    
    Molecular weight        : 73,09 g/mol    
    CAS-No.        : 68-12-2    
    EC-No.        : 200-679-5    
    Index-No.        : 616-001-00-X    
    Registration number        : 01-2119475605-32-XXXX    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  N,N-Dimethylformamide Included in the Candidate List of Substances of Very High Concern (SVHC)
    according to Regulation (EC) No. 1907/2006 (REACH)
    CAS-No.        68-12-2        Flam. Liq. 3; Acute Tox. 4; Eye <= 100 %    
    EC-No.        200-679-5        Irrit. 2; Repr. 1B; H226, H319,    
    Index-No.        616-001-00-X        H312, H332, H360D, H226,    
    Registration number 01-2119475605-32-XXXX H312 + H332, H319, H360
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  N,N-Dimethylformamide Included in the Candidate List of Substances of Very High Concern (SVHC)
    according to Regulation (EC) No. 1907/2006 (REACH)
    CAS-No.        68-12-2        T, Repr.Cat.2, R61 - R20/21 - <= 100 %    
    EC-No.        200-679-5        R36    
    Index-No.        616-001-00-X    
    Registration number 01-2119475605-32-XXXX
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    No data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides, Nitrogen oxides (NOx)
  Advice for firefighters
    Wear self-contained breathing apparatus for firefighting if necessary.
  Further information
    Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
    Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
    form explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13).
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation
    of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
    Handle and store under inert gas.
    Storage class (TRGS 510): Flammable liquids
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Derived No Effect Level (DNEL)
    Application Area        Exposure        Health effect        Value    
    Workers        Skin contact        Acute systemic effects        26,3mg/kg BW/d    
    Workers        Inhalation        Acute systemic effects        30 mg/m3    
    Workers        Skin contact        Long-term systemic effects        3,31mg/kg BW/d    
    Workers        Inhalation        Long-term systemic effects        15 mg/m3    
    Workers        Inhalation        Long-term local effects        15 mg/m3    
    Workers        Inhalation        Acute local effects        30 mg/m3    
  Predicted No Effect Concentration (PNEC)
    Compartment        Value    
    Water        30 mg/l    
    Soil        16,235 mg/kg    
    Marine water        3 mg/kg    
    Fresh water        30 mg/l    
    Fresh water sediment        25,05 mg/kg    
    Onsite sewage treatment plant        123 mg/l    
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Full contact
    Material: butyl-rubber
    Minimum layer thickness: 0,3 mm
    Break through time: 480 min
    Material tested:Butoject® (KCL 897 / Z677647, Size M)
    Splash contact
    Material: Nature latex/chloroprene
    Minimum layer thickness: 0,6 mm
    Break through time: 30 min
    Material tested:Lapren® (KCL 706 / Z677558, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The
    type of protective equipment must be selected according to the concentration and amount of the
    dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: liquid, clear    
    Colour: colourless
    b) Odour        amine-like    
    c) Odour Threshold        No data available    
    d) pH        6,7    
    e) Melting point/freezing        Melting point/range: -61 °C    
    f) Initial boiling point and 153 °C
    boiling range
    g) Flash point        58 °C - closed cup    
    h) Evaporation rate        No data available    
    i) Flammability (solid, gas) No data available
    j) Upper/lower        Upper explosion limit: 15,2 %(V)    
    flammability or        Lower explosion limit: 2,2 %(V)    
    explosive limits
    k) Vapour pressure        3,60 hPa at 20 °C    
    5,16 hPa at 25 °C
    l) Vapour density        2,52 - (Air = 1.0)    
    m) Relative density        0,944 g/mL    
    n) Water solubility        completely miscible    
    o) Partition coefficient: n- log Pow: -1,01
    p) Auto-ignition        No data available    
    q) Decomposition        No data available    
    r) Viscosity        No data available    
    s) Explosive properties        No data available    
    t) Oxidizing properties        No data available    
  Other safety information
    Relative vapour density 2,52 - (Air = 1.0)

SECTION 10: Stability and reactivity
    No data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    No data available
  Conditions to avoid
    Heat, flames and sparks.
  Incompatible materials
    Strong oxidizing agents
  Hazardous decomposition products
    Other decomposition products - No data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LD50 Oral - Rat - 2.800 mg/kg
    LC50 Inhalation - Rat - 4 h - 9 - 15 mg/l
    LD50 Dermal - Rabbit - 1.500 mg/kg
  Skin corrosion/irritation
    Skin - Human
    Result: Mild skin irritation - 24 h
  Serious eye damage/eye irritation
    Eyes - Rabbit
    Result: Moderate eye irritation
  Respiratory or skin sensitisation
    No data available
  Germ cell mutagenicity
    Mutation in mammalian somatic cells.
    This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC,
    ACGIH, NTP, or EPA classification.
    IARC:        3 - Group 3: Not classifiable as to its carcinogenicity to humans (N,N-Dimethylformamide)    
  Reproductive toxicity
    May cause congenital malformation in the fetus.
  Specific target organ toxicity - single exposure
    No data available
  Specific target organ toxicity - repeated exposure
    No data available
  Aspiration hazard
    No data available
  Additional Information
    RTECS: LQ2100000
    Warning: intolerance for alcohol can occur up to 4 days after dimethylformamide exposure. N,N-
    dimethylformamide is considered to be a potent liver toxin., Vomiting, Diarrhoea, Abdominal pain, To the
    best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly

SECTION 12: Ecological information
    Toxicity to fish        LC50 - Oncorhynchus mykiss (rainbow trout) - 9.000 - 13.000 mg/l - 96 h    
    LC50 - Lepomis macrochirus (Bluegill) - 6.700 - 7.500 mg/l - 96 h
    LC50 - Pimephales promelas (fathead minnow) - 10.400 - 10.800 mg/l - 96 h
    LC50 - Oncorhynchus mykiss (rainbow trout) - 9.800 mg/l - 96 h
    LC50 - Lepomis macrochirus (Bluegill) - 6.300 mg/l - 96 h
    LC50 - Pimephales promelas (fathead minnow) - 10.600 mg/l - 96 h
    Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 9.600 - 13.100 mg/l - 48 h
    other aquatic
    EC50 - Daphnia magna (Water flea) - 15.700 mg/l - 48 h
    Toxicity to algae        LC50 - Desmodesmus subspicatus (green algae) - > 500 mg/l - 96 h    
  Persistence and degradability
    Biodegradability        Result: > 90 % - Readily biodegradable.    
  Bioaccumulative potential
    No data available
  Mobility in soil
    No data available
  Results of PBT and vPvB assessment
    This substance/mixture contains no components considered to be either persistent, bioaccumulative and
    toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
  Other adverse effects
    No data available

SECTION 13: Disposal considerations
  Waste treatment methods
    Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
    as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 2265        IMDG: 2265        IATA: 2265    
  UN proper shipping name
    IATA:        N,N-Dimethylformamide    
  Transport hazard class(es)
    ADR/RID: 3        IMDG: 3        IATA: 3    
  Packaging group
    ADR/RID: III        IMDG: III        IATA: III    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    No data available

SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
  Authorisations and/or restrictions on use
    N,N-Dimethylformamide        CAS-No.: 68-12-2    
    REACH - Candidate List of Substances of Very High Concern for Authorisation (Article 59).
    Toxic for reproduction (article 57c)
  Chemical Safety Assessment
    A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information
  Full text of H-Statements referred to under sections 2 and 3.
    Acute Tox.        Acute toxicity    
    Eye Irrit.        Eye irritation    
    Flam. Liq.        Flammable liquids    
    H226        Flammable liquid and vapour.    
    H312        Harmful in contact with skin.    
    H312 + H332        Harmful in contact with skin or if inhaled    
    H319        Causes serious eye irritation.    
    H332        Harmful if inhaled.    
    H360        May damage fertility or the unborn child.    
    H360D        May damage the unborn child.    
    Repr.        Reproductive toxicity    
  Full text of R-phrases referred to under sections 2 and 3
    T        Toxic    
    R20/21        Harmful by inhalation and in contact with skin.    
    R36        Irritating to eyes.    
    R61        May cause harm to the unborn child.    
    Repr.Cat.2        Toxic to Reproduction Category 2    
  Further information
    Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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