Dextromethorphan Hydrobromide Monohydrate 6700-34-1 MSDS

Section 1. Chemical Product and Company Identification
    Dextromethorphan HBr monohydrate
    Common Name/
    Trade Name
    Commercial Name(s)
    Chemical Name
    Chemical Family
    Dextromethorphan HBr monohydrate

Section 4. First Aid Measures
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water    
    for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.
    Skin Contact        Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation    
    develops. Cold water may be used.
    Serious Skin Contact        Not available.    
    Inhalation        If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.    
    Get medical attention.
    Serious Inhalation        Not available.    
    Ingestion        Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to    
    an unconscious person. If large quantities of this material are swallowed, call a physician immediately.
    Loosen tight clothing such as a collar, tie, belt or waistband.
    Serious Ingestion        Not available.    

Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Not available.
    Flash Points
    Flammable Limits        Not available.    
    Products of Combustion        These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds.    
    Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
    Various Substances        Non-flammable in presence of shocks.    
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards in
    Slightly explosive in presence of open flames and sparks.
    Presence of Various
    SMALL FIRE: Use DRY chemical powder.
    Fire Fighting Media
    LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    and Instructions
    Special Remarks on        When heated to decomposition it emits toxic fumes of NOx and HBr.    
    As with most organic solids, fire is possible at elevated temperatures
    Fire Hazards
    Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a
    potential dust explosion hazard.

Section 6. Accidental Release Measures
    Small Spill        Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by    
    spreading water on the contaminated surface and dispose of according to local and regional authority
    Large Spill        Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading    
    water on the contaminated surface and allow to evacuate through the sanitary system.

Section 7. Handling and Storage
    Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
    residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust.
    Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If
    ingested, seek medical advice immediately and show the container or the label. Keep away from
    incompatibles such as oxidizing agents, alkalis.
    Storage        Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in    
    light-resistant containers.
    Dextromethorphan HBr monohydrate

Section 8. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels    
    below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep
    exposure to airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.    
    Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be
    a Large Spill        used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a    
    specialist BEFORE handling this product.
    Exposure Limits        Not available.    

Section 9. Physical and Chemical Properties
    Physical state and appearance Solid. (Crystalline powder.)        Odor        Slight.    
    Taste        Not available.    
    Molecular Weight        370.33 g/mole    
    White. Off-white.
    Not available.
    pH (1% soln/water)
    Boiling Point        Not available.    
    Decomposition temperature: 122°C (251.6°F)
    Melting Point
    Critical Temperature        Not available.    
    Not available.
    Specific Gravity
    Vapor Pressure        Not applicable.    
    Vapor Density        Not available.    
    Not available.
    Odor Threshold        Not available.    
    Not available.
    Water/Oil Dist. Coeff.
    Ionicity (in Water)        Not available.    
    Dispersion Properties        See solubility in water, methanol.    
    Solubility        Soluble in methanol.    
    Partially soluble in cold water.

Section 10. Stability and Reactivity Data
    The product is stable.
    Instability Temperature        Not available.    
    Excess heat, dust generation, incompatible materials
    Conditions of Instability
    Incompatibility with various Reactive with oxidizing agents, alkalis.
    Corrosivity        Non-corrosive in presence of glass.    
    Special Remarks on        Sensitive to light.    
    Special Remarks on        Not available.    
    Will not occur.
    Dextromethorphan HBr monohydrate

Section 11. Toxicological Information
    Routes of Entry        Inhalation. Ingestion.    
    Toxicity to Animals        Acute oral toxicity (LD50): 165 mg/kg [Mouse]. (for the anhydrous form)    
    Chronic Effects on Humans Not available.
    Other Toxic Effects on        Hazardous in case of ingestion, of inhalation.    
    Humans        Slightly hazardous in case of skin contact (irritant).    
    Special Remarks on        Not available.    
    Toxicity to Animals
    Special Remarks on        Not available.    
    Chronic Effects on Humans
    Special Remarks on other        Acute Potential Health Effects:    
    Toxic Effects on Humans        Skin: May cause skin irritation.    
    Eyes: May cause eye irritation.
    Inhalation: May cause respiratory tract irritation.
    Ingestion: May cause gastrointestinal tract irritation with stomach pain, severe nausea or vomiting, difficulty
    in urination. May affect behavior/central nervous system(headache, drowsiness or dizziness, unusual
    excitement, confusion, nervousness or irritability, shakiness and unsteady walk, coma, toxic psychosis
    (hyperactivity, vusual and auditory hallucinations), muscle contraction or spasticity, rigidity, somnolence,
    convulsions, ataxia), respiration (respiratory depression, dyspnea), eyes/vision (blurred vision, pupilliary
    Chronic Potential Health Effects:
    Prolonged or repeated skin contact, inhalation or ingestion can cause allergic reaction.
    Conditions aggravated by exposure may include hypersensitivity to material, asthma, bronchitis,
    emphysema, productive cough, and concurrent therapy with MAO inhibitors.

Section 12. Ecological Information
    Not available.
    Not available.
    BOD5 and COD
    Products of Biodegradation        Possibly hazardous short term degradation products are not likely. However, long term degradation    
    products may arise.
    Toxicity of the Products        The products of degradation are as toxic as the product itself.    
    of Biodegradation
    Special Remarks on the        Not available.    
    Products of Biodegradation

Section 13. Disposal Considerations
    Waste Disposal        Waste must be disposed of in accordance with federal, state and local environmental    
    control regulations.

Section 14. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    Identification        Not applicable.    
    Special Provisions for        Not applicable.    
    DOT (Pictograms)
    Dextromethorphan HBr monohydrate

Section 15. Other Regulatory Information and Pictograms
    No products were found.
    Federal and State
    California        California prop. 65: This product contains the following ingredients for which the State of California has    
    Proposition 65        found to cause cancer which would require a warning under the statute: No products were found.    
    California prop. 65: This product contains the following ingredients for which the State of California has
    found to cause birth defects which would require a warning under the statute: No products were found.
    Other Regulations        OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).    
    WHMIS (Canada) CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
    Other Classifications
    DSCL (EEC)        R22- Harmful if swallowed.        S46- If swallowed, seek medical advice    
    immediately and show this container or label.
    Health Hazard
    HMIS (U.S.A.)        2 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    2 0 Reactivity
    Specific hazard
    Personal Protection
    WHMIS (Canada)
    DSCL (Europe)
    TDG (Canada)
    ADR (Europe)
    Protective Equipment
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or
    Safety glasses.


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