Ethyl diazoacetate

CAS No.: 623-73-4
Formula: C4H6N2O2
Exact Mass: 114.04300
Molecular Weight: 114.10300
PSA: 63.69000
LogP: -0.06884
Ethyl diazoacetate 623-73-4 MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Ethyl diazoacetate    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
    CAS-No.        : 623-73-4    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Flammable liquids (Category 3), H226
    Self reactive substances (Type E), H242
    Acute toxicity, Oral (Category 4), H302
    Carcinogenicity (Category 2), H351
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    Xn Harmful        R22    
    Xn Harmful        R40    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Signal word        Warning    
    Hazard statement(s)
    H226        Flammable liquid and vapour.    
    H242        Heating may cause a fire.    
    H302        Harmful if swallowed.    
    H351        Suspected of causing cancer.    
    Precautionary statement(s)
    P281        Use personal protective equipment as required.    
    Supplemental Hazard        none    
  Other hazards
    Heating may cause an explosion.

SECTION 3: Composition/information on ingredients
    Formula        : C4H6N2O2    
    Molecular Weight        : 114,10 g/mol    
    CAS-No.        : 623-73-4    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  Ethyl diazoacetate
    CAS-No.        623-73-4        Flam. Liq. 3; Acute Tox. 4;        50 - 100 %    
    EC-No.        210-810-8        H226, H302    
  Methylene chloride
    CAS-No.        75-09-2        Carc. 2; H351        20 - 25 %    
    EC-No.        200-838-9    
    Index-No.        602-004-00-3    
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  Ethyl diazoacetate
    CAS-No.        623-73-4        Xn, R 5 - R10 - R22        50 - 100 %    
    EC-No.        210-810-8    
  Methylene chloride
    CAS-No.        75-09-2        Xn, Carc.Cat.3, R40        20 - 25 %    
    EC-No.        200-838-9    
    Index-No.        602-004-00-3    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
    Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
    form explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13).
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    charge.Keep away from heat and sources of ignition.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
    Recommended storage temperature: 2 - 8 °C
  Specific end use(s)
    A part from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
  Body Protection
    Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type
    of protective equipment must be selected according to the concentration and amount of the
    dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: clear, liquid    
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        Melting point/range: -22 °C - lit.    
    f) Initial boiling point and 140 - 141 °C at 960 hPa - lit.
    boiling range
    g) Flash point        47 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        no data available    
    flammability or
    explosive limits
    k) Vapour pressure        no data available    
    l) Vapour density        no data available    
    m) Relative density        1,085 g/mL at 25 °C    
    n) Water solubility        slightly soluble    
    o) Partition coefficient: n- no data available
    p) Auto-ignition        no data available    
    q) Decomposition        Type E    
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    no data available

SECTION 10: Stability and reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Heat, flames and sparks.
  Incompatible materials
    Strong oxidizing agents, Alkali metals, Aluminum, Bases
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LD50 Oral - rat - 400 mg/kg (Ethyl diazoacetate)
    LD50 Intravenous - rat - 280 mg/kg (Ethyl diazoacetate)
    Remarks: Behavioral:Somnolence (general depressed activity). Lungs, Thorax, or Respiration:Dyspnea.
  Skin corrosion/irritation
    no data available
  Serious eye damage/eye irritation
    no data available (Ethyl diazoacetate)
  Respiratory or skin sensitisation
    no data available (Ethyl diazoacetate)
  Germ cell mutagenicity
    no data available (Ethyl diazoacetate)
    Carcinogenicity classification not possible from current data. (Ethyl diazoacetate)
    IARC:        2B - Group 2B: Possibly carcinogenic to humans (Methylene chloride)    
  Reproductive toxicity
    no data available (Ethyl diazoacetate)
  Specific target organ toxicity - single exposure
    no data available (Ethyl diazoacetate)
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available (Ethyl diazoacetate)
  Additional Information
    RTECS: Not available
    Dichloromethane is metabolized in the body producing carbon monoxide which increases and sustains
    carboxyhemoglobin levels in the blood, reducing the oxygen-carrying capacity of the blood., Acts as a
    simple asphyxiant by displacing air., Acute symptoms of overexposure include:, Difficulty in breathing,
    Headache, Dizziness, Prolonged or repeated exposure to skin causes defatting and dermatitis., Contact
    with eyes can cause:, Redness, Effects due to ingestion may include:, Gastrointestinal disturbance,
    Central nervous system depression, Paresthesia., Convulsions, pulmonary edema, Symptoms may be
    delayed., Increased liver enzymes. (Ethyl diazoacetate)

SECTION 12: Ecological information
    no data available
  Persistence and degradability
    no data available
  Bioaccumulative potential
    no data available
  Mobility in soil
    no data available (Ethyl diazoacetate)
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    no data available

SECTION 13: Disposal considerations
  Waste treatment methods
    Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
    as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 3227        IMDG: 3227        IATA: 3227    
  UN proper shipping name
    ADR/RID: SELF-REACTIVE LIQUID TYPE E (Ethyl diazoacetate)
    IMDG: SELF-REACTIVE LIQUID TYPE E (Ethyl diazoacetate)
    IATA:        Self-reactive liquid type E (Ethyl diazoacetate)    
    Special Provisions: “Keep away from heat” label required.
  Transport hazard class(es)
    ADR/RID: 4.1        IMDG: 4.1        IATA: 4.1 (HEAT)    
  Packaging group
    ADR/RID: -        IMDG: -        IATA: -    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
  Further information
    Special competent authority approval required!

SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
    no data available
  Chemical Safety Assessment
    For this product a chemical safety assessment was not carried out

SECTION 16: Other information
  Full text of H-Statements referred to under sections 2 and 3.
    Acute Tox.        Acute toxicity    
    Carc.        Carcinogenicity    
    Flam. Liq.        Flammable liquids    
    H226        Flammable liquid and vapour.    
    H242        Heating may cause a fire.    
    H302        Harmful if swallowed.    
    H351        Suspected of causing cancer.    
  Full text of R-phrases referred to under sections 2 and 3
    Xn Harmful
    R 5 Heating may cause an explosion.
    R10 Flammable.
    R22 Harmful if swallowed.
    R40 Limited evidence of a carcinogenic effect.
  Further information
    Copyright 2013 Co. LLC. License granted to make unlimited paper copies for internal use
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.