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β-propiolactone
CAS No.: 57-57-8
Synonyms:
Formula: C3H4O2
Exact Mass: 72.02110
Molecular Weight: 72.06270
PSA: 26.30000
LogP: -0.06670
Reference Price: $2,437/kg Inquiry Now
β-propiolactone 57-57-8 MSDS
Name: -Propiolactone 98% Material Safety Data Sheet
Synonym: 2-Oxetanone; beta-Propiolactone; BPL; Hydracrylic acid, beta-lactone; 3-Propanolide; 3-Propiolactone
CAS: 57-57-8
Section 1 - Chemical Product   MSDS Name:-Propiolactone 98% Material Safety Data Sheet
Synonym:2-Oxetanone; beta-Propiolactone; BPL; Hydracrylic acid, beta-lactone; 3-Propanolide; 3-Propiolactone

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
57-57-8 -Propiolactone 98 200-340-1
Hazard Symbols: T+
Risk Phrases: 26 36/38 45

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Very toxic by inhalation. Irritating to eyes and skin. May cause cancer.Heat sensitive.Cancer suspect agent.
Potential Health Effects
Eye:
Causes eye irritation and burns. May cause permanent corneal opacification.
Skin:
May be harmful if absorbed through the skin. Causes irritation with burning pain, scaling, itching and redness. May cause erythema (redness) and blistering.
Ingestion:
May be harmful if swallowed. May cause irritation of the digestive tract and possible burns. May cause nausea, vomiting, headache, cramps, chills and drowsiness.
Inhalation:
Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema.
Toxic if inhaled. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
Inhalation may cause sore throat, shortness of breath, labored breathing, coughing, and pulmonary edema.
Chronic:
Animal studies have reported the development of tumors.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water.
Remove contaminated clothing and shoes. Get medical aid. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
POISON material. If inhaled, get medical aid immediately. Remove victim to fresh air. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustible liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back.
Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Neutralize spill with sodium bicarbonate. Cover with sand, dry lime or soda ash and place in a closed container for disposal. Remove all sources of ignition. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Do not breathe vapor or mist. Pure vapor will be uninhibited and may polymerize in vents or other confined spaces. Use only with adequate ventilation or respiratory protection.
Storage:
Keep away from sources of ignition. Store in a tightly closed container. Deep freeze (below -20C). Store protected from light.
Store under argon.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. See 29CFR 1910.1003 for specific regulatory requirements applying to areas containing a listed carcinogen, signs, training, reports, and medical surveillance programs.
Exposure Limits CAS# 57-57-8: United States OSHA: ; (Cancer suspect agent - see 29 CFR 1910.101 Belgium - TWA: 0.5 ppm VLE; 1.5 mg/m3 VLE Spain: 0.5 ppm VLA-ED; 1.5 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Color: clear, colorless
Odor: strong, pungent - sweetish odor
pH: Not available.
Vapor Pressure: 3.4 mm Hg @ 25 deg C
Viscosity: Not available.
Boiling Point: 162 deg C (dec)
Freezing/Melting Point: -33 deg C
Autoignition Temperature: Not available.
Flash Point: 70 deg C ( 158.00 deg F)
Explosion Limits, lower: 2.90 vol %
Explosion Limits, upper: Not available.
Decomposition Temperature: 162 deg C
Solubility in water: 37% in water
Specific Gravity/Density: 1.1460 g/ml
Molecular Formula: C3H4O2
Molecular Weight: 72.06

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Not available.
Conditions to Avoid:
Ignition sources, moisture, heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases, strong acids, acetates, halogens, thiocyanates, 2-aminoethanol, ammonium hydroxide, aniline, chlorosulfonic acid, ethylene diamine, ethyleneimine, hydrochloric acid, hydrofluoric acid, nitric acid, oleum, pyridine, sodium hydroxide, sulfuric acid.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 57-57-8: RQ7350000 LD50/LC50:
CAS# 57-57-8: Inhalation, rat: LC50 = 25 ppm/6H.
The 30-minute LC50 value of BPL in rats was approximately 250 ppm.
(Documentation of the TLV - 7th edition.) Carcinogenicity:
-Propiolactone - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 1/1/88 NTP: Suspect carcinogen IARC: Group 2B carcinogen Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: TOXIC LIQUID, ORGANIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2810
Packing Group: II
IMO
Shipping Name: TOXIC LIQUID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2810
Packing Group: II
RID/ADR
Shipping Name: TOXIC LIQUID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2810
Packing group: II
USA RQ: CAS# 57-57-8: 10 lb final RQ; 4.54 kg final RQ

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+
Risk Phrases:
R 45 May cause cancer.
R 26 Very toxic by inhalation.
R 36/38 Irritating to eyes and skin.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 57-57-8: No information available.
Canada
CAS# 57-57-8 is listed on Canada's NDSL List.
CAS# 57-57-8 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 57-57-8 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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