methyl isothiocyanate
CAS No.: 556-61-6
Synonyms:
Formula: C2H3NS
Exact Mass: 72.99860
Molecular Weight: 73.11690
PSA: 44.45000
LogP: 0.71900
methyl isothiocyanate 556-61-6 MSDS
Name: Methyl Isothiocyanate Material Safety Data Sheet
Synonym: Isothiocyanatomethane; Isothiocyanic Acid, Methyl Ester; Methyl Mustard Oil
CAS: 556-61-6
Section 1 - Chemical Product   MSDS Name:Methyl Isothiocyanate Material Safety Data Sheet
Synonym:Isothiocyanatomethane; Isothiocyanic Acid, Methyl Ester; Methyl Mustard Oil

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
556-61-6 Methyl Isothiocyanate ca 100 209-132-5
Hazard Symbols: T
Risk Phrases: 23/25 34 43

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Toxic by inhalation and if swallowed. Causes burns. May cause sensitization by skin contact.Corrosive.
Potential Health Effects
Eye:
Causes eye burns. May cause chemical conjunctivitis and corneal damage.
Skin:
May be fatal if absorbed through the skin. Causes skin burns. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. This material is a vesicant, that is, it will induce blistering. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
Harmful if swallowed. May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. Human fatalities have been reported from acute poisoning. May cause systemic effects.
Inhalation:
Harmful if inhaled. Causes chemical burns to the respiratory tract.
Aspiration may lead to pulmonary edema. May cause systemic effects.
Chronic:
Repeated exposure may cause sensitization dermatitis. Effects may be delayed.

Section 4 - FIRST AID MEASURES
  Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Will react with water to form toxic and corrosive fumes. Vapors may be heavier than air.
They can spread along the ground and collect in low or confined areas. Contact with metals may evolve flammable hydrogen gas.
Containers may explode when heated. Runoff to sewer may create fire or explosion hazard.
Extinguishing Media:
For large fires, use water spray, fog, or alcohol-resistant foam. Do NOT get water inside containers. Do NOT use straight streams of water. For small fires, use carbon dioxide, dry chemical, dry sand, or alcohol-resistant foam. Most foams will react with the material and release corrosive/toxic gases. Cool containers with flooding quantities of water until well after fire is out.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Remove all sources of ignition. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Discard contaminated shoes.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Keep away from water. Corrosives area. Do not store in metal containers.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 556-61-6: Russia: 0.1 mg/m3 TWA Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear polyethylene gloves, apron, and/or clothing.
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear polyethylene gloves, apron, and/or clothing.
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystals
Color: colorless
Odor: pungent odor
pH: Not available.
Vapor Pressure: 19 mm Hg @ 25C
Viscosity: Not available.
Boiling Point: 119 deg C @ 758mmHg
Freezing/Melting Point: 35.00 - 37.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Slightly soluble.
Specific Gravity/Density: 1.0690g/cm3
Molecular Formula: C2H3NS
Molecular Weight: 73.12

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Water, strong oxidizing agents, acids, strong bases, alcohols, amines.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 556-61-6: PA9625000 LD50/LC50:
CAS# 556-61-6: Draize test, rabbit, eye: 100 mg Severe; Draize test, rabbit, skin: 500 mg/24H Moderate; Inhalation, rat: LC50 = 1900 mg/m3/1H; Oral, mouse: LD50 = 90 mg/kg; Oral, rat: LD50 = 72 mg/kg; Skin, rabbit: LD50 = 33 mg/kg; Skin, rat: LD50 = 2780 mg/kg.
Carcinogenicity:
Methyl Isothiocyanate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Fish: Bluegill/Sunfish: 0.13mg/L; 96HFish: Carp: 37mg/L; 96H Other For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND EXPOSURE DATA."

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: METHYL ISOTHIOCYANATE
Hazard Class: 6.1 (3)
UN Number: 2477
Packing Group:
IMO
Shipping Name: METHYL ISOTHIOCYANATE
Hazard Class: 6.1 (3)
UN Number: 2477
Packing Group: I
RID/ADR
Shipping Name: METHYL ISOTHIOCYANATE
Hazard Class: 6.1
UN Number: 2477
Packing group: II

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 23/25 Toxic by inhalation and if swallowed.
R 34 Causes burns.
R 43 May cause sensitization by skin contact.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
S 38 In case of insufficient ventilation, wear
suitable respiratory equipment.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 556-61-6: 3
Canada
CAS# 556-61-6 is listed on Canada's DSL List.
CAS# 556-61-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 556-61-6 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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