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Betahistine Mesylate
CAS No.: 54856-23-4
Synonyms:
Formula: C10H20N2O6S2
Exact Mass: 328.07600
Molecular Weight: 328.40600
PSA: 150.42000
LogP: 2.40400
Reference Price: $388/kg Inquiry Now
Betahistine Mesylate 54856-23-4 MSDS

Section I.Chemical Product and Company Identification
    Chemical Name Betahistine Methanesulfonate
    Portland OR
    Synonym        Betahistine Mesylate    
    C8H12N2•2CH3SO3H
    Chemical Formula
    54856-23-4
    CAS Number

Section II.        Composition and Information on Ingredients    
    Toxicology Data
    Chemical Name        CAS Number Percent (%)        TLV/PEL    
    Betahistine Methanesulfonate        54856-23-4        Min. 99.0 Not available.        Rat LD50 (oral) 3030 mg/kg    
    (HPLC,T)        Rat LD50 (intravenous) 604 mg/kg    
    Mouse LD50 (oral) 500 mg/kg
    Mouse LD50 (subcutaneous) 1630
    mg/kg
    Guinea pig LD50 (oral) 1400 mg/kg

Section III. Hazards Identification
    Acute Health Effects        No specific information is available in our data base regarding the toxic effects of this material for humans. However,    
    exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
    inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling
    this compound.
    CARCINOGENIC EFFECTS : Not available.
    Chronic Health Effects
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    There is no known effect from chronic exposure to this product. Repeated or prolonged exposure to this compound is not
    known to aggravate existing medical conditions.

Section IV.        First Aid Measures    
    Eye Contact        Check for and remove any contact lenses. IMMEDIATELY flush eyes with running water for at least 15 minutes, keeping    
    eyelids open. COLD water may be used. DO NOT use an eye ointment. Flush eyes with running water for a minimum of 15
    minutes, occasionally lifting the upper and lower eyelids. Seek medical attention. Treat symptomatically and supportively.
    Skin Contact        After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running    
    water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. COLD water may be used.
    Cover the irritated skin with an emollient. Seek medical attention. Treat symptomatically and supportively. Wash any
    contaminated clothing before reusing.
    If the victim is not breathing, perform artificial respiration. Loosen tight clothing such as a collar, tie, belt or waistband. If
    Inhalation
    breathing is difficult, oxygen can be administered. Seek medical attention. Treat symptomatically and supportively.
    INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
    Ingestion
    Loosen tight clothing such as a collar, tie, belt, or waistband. If the victim is not breathing, administer artificial respiration.
    Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material was
    ingested; the absence of such signs, however, is not conclusive. Seek immediate medical attention and, if possible, show the
    chemical label. Treat symptomatically and supportively.

Section V.        Fire and Explosion Data    
    Not available.
    Combustible.        Auto-Ignition    
    Flammability
    Flash Points        Flammable Limits        Not available.    
    Not available.
    Combustion Products        These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), sulfur oxides (SO2, SO3...).    
    Fire Hazards
    No specific information is available regarding the flammability of this compound in the presence of various materials.
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards
    Risks of explosion of the product in presence of static discharge: Not available.
    No additional information is available regarding the risks of explosion.
    Fire Fighting Media        SMALL FIRE: Use DRY chemicals, CO2, water spray or foam.    
    LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
    and Instructions
    Continued on Next Page
    Betahistine Methanesulfonate

Section VI.        Accidental Release Measures    
    Spill Cleanup        In case of a spill and/or a leak, always shut off any sources of ignition, ventilate the area, and exercise caution. Use a    
    shovel to put the material into a convenient waste disposal container. Finish cleaning the spill by rinsing any contaminated
    Instructions
    surfaces with copious amounts of water. Consult federal, state, and/or local authorities for assistance on disposal.

Section VII. Handling and Storage
    Handling and Storage        HYGROSCOPIC. Keep away from heat and sources of ignition. Mechanical exhaust required. When not in use, tightly seal    
    the container and store in a dry, cool place. Avoid excessive heat and light. DO NOT breathe dust. In case of insufficient
    Information
    ventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and show the label when possible.
    Treat symptomatically and supportively. Avoid contact with skin and eyes.
    Always store away from incompatible compounds such as oxidizing agents.

Section VIII. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended    
    exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
    below the exposure limit.
    Personal Protection        Splash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid    
    inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
    product.
    Exposure Limits        Not available.    

Section IX. Physical and Chemical Properties
    Physical state @ 20°C        Solid.        Solubility        Soluble in cold water, hot water.    
    Not available.
    Specific Gravity
    Molecular Weight        328.41        Partition Coefficient        Not available.    
    Boiling Point        Not available.        Not available.    
    Vapor Pressure
    Melting Point        112°C (233.6°F)        Vapor Density        Not available.    
    Not available.        Not available.    
    Refractive Index        Volatility    
    Critical Temperature        Not available.        Odor        Not available.    
    Not available.        Not available.    
    Viscosity        Taste    

Section X.        Stability and Reactivity Data    
    Stability    
This material is stable if stored under proper conditions. (See Section VII for instructions)    
    Conditions of Instability        Hygroscopic; keep container tightly closed. Avoid excessive heat and light.    
    Incompatibilities        Reactive with oxidizing agents, moisture.    

Section XI. Toxicological Information
    RTECS Number        UT2970200    
    Eye contact. Inhalation. Ingestion.
    Routes of Exposure
    Rat LD50 (oral) 3030 mg/kg
    Toxicity Data
    Rat LD50 (intravenous) 604 mg/kg
    Mouse LD50 (oral) 500 mg/kg
    Mouse LD50 (subcutaneous) 1630 mg/kg
    Guinea pig LD50 (oral) 1400 mg/kg
    CARCINOGENIC EFFECTS : Not available.
    Chronic Toxic Effects
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    There is no known effect from chronic exposure to this product. Repeated or prolonged exposure to this compound is not
    known to aggravate existing medical conditions.
    No specific information is available in our data base regarding the toxic effects of this material for humans. However,
    Acute Toxic Effects
    exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
    inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling this
    compound.
    Continued on Next Page
    Betahistine Methanesulfonate

Section XII.        Ecological Information    
    Ecotoxicity        Not available.    
    Not available.
    Environmental Fate

Section XIII. Disposal Considerations
    Recycle to process, if possible. Consult your local or regional authorities. You may be able to dissolve or mix material with a
    Waste Disposal
    combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
    federal, state, and local regulations when disposing of this substance.

Section XIV. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    Not applicable.
    PIN Number
    Proper Shipping Name        Not applicable.    
    Not applicable.
    Packing Group (PG)
    DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
    TSCA Chemical Inventory        This product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40    
    CFR 720.36 (C) for those products not on the inventory list:
    (EPA)
    (i) These products are supplied solely for use in research and development by or under the supervision of a technically
    qualified individual as defined in 40 CFR 720.0 et sec.
    (ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
    supplied on an MSDS sheet.
    WHMIS Classification        Not controlled under WHMIS (Canada).    
    (Canada)
    EINECS Number (EEC)        Not available.    
    EEC Risk Statements        Not available.    


SECTION 16 - ADDITIONAL INFORMATION
N/A

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