Nicotine 54-11-5 MSDS
Name: Nicotine pract. 95% Material Safety Data Sheet
Synonym: S-(-)-Nicotine; beta-Pyridyl-alpha-n-methylpyrrolidine
CAS: 54-11-5
Section 1 - Chemical Product   MSDS Name:Nicotine pract. 95% Material Safety Data Sheet
Synonym:S-(-)-Nicotine; beta-Pyridyl-alpha-n-methylpyrrolidine

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
54-11-5 Nicotine 95% 200-193-3
Hazard Symbols: T+ N
Risk Phrases: 25 27 51/53

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Toxic if swallowed. Very toxic in contact with skin. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
Causes eye irritation. Causes redness and pain.
Skin:
Causes skin irritation. May be fatal if absorbed through the skin.
May cause dermatitis.
Ingestion:
Poison by ingestion. May cause adverse effects of the musculature.
May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea. May cause tremors and convulsions.
May cause muscle paralysis, respiratory failure, and possible death.
Inhalation:
May cause effects similar to those described for ingestion.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. May cause digestive tract and cardiac disturbances. Prolonged or repeated exposure may cause nausea, dizziness, and headache.

Section 4 - FIRST AID MEASURES
  Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Can form explosive mixtures at temperatures above the flashpoint.
Extinguishing Media:
For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Water or foam may cause frothing.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section).
Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not reuse this container. Do not get on skin or in eyes. Do not ingest or inhale. Use only in a chemical fume hood.
Storage:
Keep away from sources of ignition. Keep under a nitrogen blanket.
Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from strong acids. Poison room locked.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 54-11-5: United Kingdom, WEL - TWA: 0.5 mg/m3 TWA United Kingdom, WEL - STEL: 1.5 ppm STEL United States OSHA: 0.5 mg/m3 TWA Belgium - TWA: 0.5 mg/m3 VLE France - VME: 0.5 mg/m3 VME Germany: 0.07 ppm TWA; 0.47 mg/m3 TWA Germany: Skin absorber Malaysia: 0.5 mg/m3 TWA Netherlands: 0.07 ppm MAC; 0.5 mg/m3 MAC Spain: 0.5 mg/m3 VLA-ED Personal Protective Equipment Eyes: Not available.
Skin:
Wear impervious gloves.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Clear liquid
Color: brown
Odor: fish-like - weak odor
pH: Not available.
Vapor Pressure: 1.3 mbar @ 62 deg C
Viscosity: Not available.
Boiling Point: 247 deg C @ 760.00M
Freezing/Melting Point: -80 deg C
Autoignition Temperature: 240 deg C ( 464.00 deg F)
Flash Point: 101 deg C ( 213.80 deg F)
Explosion Limits, lower: .70 vol %
Explosion Limits, upper: 4.00 vol %
Decomposition Temperature:
Solubility in water: IN WATER: MISCIBLE BELOW 60C
Specific Gravity/Density: 1.0100g/cm3
Molecular Formula:
Molecular Weight: 162.23

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable at normal temperatures in tightly closed containers under an inert atmosphere. Substance undergoes color change upon exposure to light and air.
Conditions to Avoid:
Incompatible materials, light, exposure to air, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 54-11-5: QS5250000 LD50/LC50:
CAS# 54-11-5: Oral, mouse: LD50 = 3340 ug/kg; Oral, rat: LD50 = 50 mg/kg; Skin, rabbit: LD50 = 50 mg/kg; Skin, rat: LD50 = 140 mg/kg.
Carcinogenicity:
Nicotine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Fish (fresh water) 3-29ppm toxic (time period not specified).
LC50 (96hr) rainbow trout ~ 4 mg/l (Edsall, C.C. Bull. Environ. Contam.
Toxicol. 1991, 46, 173-188).
Trout, bluegill sunfish 5 ppm caused death within 22, 7 hr respectively. 5 ppm (24 hr) goldfish no effect was observed (The Toxicity of 3400 Chemicals to Fish 1987, EPA560/6-87-002, PB87-200-275, Washington DC Steel trout, bridge sucker 2 mg/l caused death within 2 hr of exposure (Lethal Effects of 2014 Chemicals to Fish 1989, EPA 560/6-89-001, PB 89-156715, Washington DC).

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: NICOTINE
Hazard Class: 6.1
UN Number: 1654
Packing Group: II
IMO
Shipping Name: NICOTINE
Hazard Class: 6.1
UN Number: 1654
Packing Group: II
RID/ADR
Shipping Name: NICOTINE
Hazard Class: 6.1
UN Number: 1654
Packing group: II
USA RQ: CAS# 54-11-5: 100 lb final RQ; 45.4 kg final RQ

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+ N
Risk Phrases:
R 25 Toxic if swallowed.
R 27 Very toxic in contact with skin.
R 51/53 Toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 54-11-5: No information available.
Canada
CAS# 54-11-5 is listed on Canada's DSL List.
CAS# 54-11-5 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 54-11-5 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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