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CAS No.: 53-03-2
Formula: C21H26O5
Exact Mass: 358.17800
Molecular Weight: 358.42800
PSA: 91.67000
LogP: 1.76580
Reference Price: $1,806/kg Post Buying Request
prednisone 53-03-2 MSDS

Section 1. Chemical Product and Company Identification
    Common Name/
    Trade Name

Section 4. First Aid Measures
    Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
    Eye Contact
    15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention if irritation occurs.
    Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
    Skin Contact
    Serious Skin Contact        Not available.    
    Inhalation        If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get    
    medical attention.
    Not available.
    Serious Inhalation
    Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
    unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
    clothing such as a collar, tie, belt or waistband.
    Not available.
    Serious Ingestion

Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Not available.
    Flash Points
    Not available.
    Flammable Limits
    These products are carbon oxides (CO, CO2).
    Products of Combustion
    Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
    Various Substances
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards in
    Slightly explosive in presence of open flames and sparks.
    Presence of Various
    SMALL FIRE: Use DRY chemical powder.
    Fire Fighting Media
    LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    and Instructions
    Material in powder form, capable of creating a dust explosion. As with most organic solids, fire is possible at elevated
    Special Remarks on
    Fire Hazards
    Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
    Special Remarks on
    explosion hazard.
    Explosion Hazards

Section 6. Accidental Release Measures
    Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading
    Small Spill
    water on the contaminated surface and dispose of according to local and regional authority requirements.
    Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on
    Large Spill
    the contaminated surface and allow to evacuate through the sanitary system.

Section 7. Handling and Storage
    Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
    breathe dust. Wear suitable protective clothing. If you feel unwell, seek medical attention and show the label when
    possible. Keep away from incompatibles such as oxidizing agents.
    Keep container tightly closed. Keep container in a cool, well-ventilated area. Material should be stored at a
    temperature less than 40 deg C., preferably between 15-30 deg. C.

Section 8. Exposure Controls/Personal Protection
    Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
    Engineering Controls
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.    
    Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to
    avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE
    of a Large Spill
    handling this product.
    Not available.
    Exposure Limits

Section 9. Physical and Chemical Properties
    Solid. (Solid crystalline powder.)        Odorless.    
    Physical state and        O dor    
    Bitter. Aftertaste.
    358.43 g/mole
    Molecular Weight
    White or nearly white.
    Not available.
    pH (1% soln/water)
    Not available.
    Boiling Point
    Decomposition temperature: 230°C (446°F) - 235 C.
    Melting Point
    Not available.
    Critical Temperature
    Not available.
    Specific Gravity
    Not applicable.
    Vapor Pressure
    Not available.
    Vapor Density
    Not available.
    Not available.
    Odor Threshold
    Not available.
    Water/Oil Dist. Coeff.
    Not available.
    Ionicity (in Water)
    Not available.
    Dispersion Properties
    Very slightly soluble in cold water.
    Slightly soluble in methanol.
    1 g soluble in 150 ml alcohol.
    1 g soluble in 200 ml chloroform.

Section 10. Stability and Reactivity Data
    The product is stable.
    Not available.
    Instability Temperature
    Conditions of Instability Excess heat, incompatible materials.
    Incompatibility with various Reactive with oxidizing agents.
    Non-corrosive in presence of glass.
    Not available.
    Special Remarks on
    Not available.
    Special Remarks on
    Will not occur.

Section 11. Toxicological Information
    Inhalation. Ingestion.
    Routes of Entry
    Toxicity to Animals        LD50: Not available.    
    LC50: Not available.
    Chronic Effects on Humans CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC.
    MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
    Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
    Other Toxic Effects on
    Not available.
    Special Remarks on
    Toxicity to Animals
    May cause adverse reproductive effects and cancer based on animal test data.
    Special Remarks on
    Chronic Effects on Humans May affect genetic material (mutagenic).
    Human: small amount excreted in maternal milk.
    Acute Potential Health Effects:
    Special Remarks on other
    Skin: May cause skin irritation. May cause skin sensitization, an allergic reaction.
    Toxic Effects on Humans
    Eyes: May cause eye irritation.
    Inhalation: May cause respiratory tract irritation.
    Ingestion: May cause gastritis with nausea, vomiting, abdominal distention, ulcerative esophagitis, increased
    sweating. May affect metabolism and cause disturbance of electrolyte balance which is manifest in the retention of
    sodium and water, with edema and hypertension, and in the increased excretion of potassium with the possibility of
    hypokalaemic alkalosis. Cardiac faillure may be induced in sensitive individuals.
    Chronic Potential Health Effects:
    Skin: Prolonged or repeated skin contact may cause sensitization, an allergic reaction.
    Eyes: Prolonged contact with eyes may affect vision (cataracts)
    Inhalation/Ingestion: May cause anaphylaxis, an allergic reaction. Prolonged or repeated inhalation or ingestion of
    corticosteroids may also cause thinning of the skin, inpaired wound healing and other dermatologic reactions
    (erythema, petechiae and ecchymoses).
    Ingestion: Prolonged or repeated ingestion of corticosteroids may cause nausea, vomiting, abdominal distention,
    peptic ulcer with possible perforation and hemorrhage, possible hypersensitization, swelling of the feet and lower legs
    due to electrolyte imbalance and sodium retention, irregular hearbeat, acute adrenal insufficiency, osteoporosis,
    muscle weakness, loss of muscle mass, vertebral compression fractures, pathologic fracture of long bones, aseptic
    necrosis of femoral and humeral heads, effect glucose tolerance (causing decreased carbohydrate tolerance resulting
    in manifestations of latent Diabetes melliltus, increased requirements for insulin or oral hypoglycemifcagents in
    diabetes), the liver, pancreas (pancreatitis), eyes/vision (cataracts, glaucoma, increased intraocular pressure),
    behavior/central nervous system/nervous system (mental disturbances such as psychosis, euphoria, depression, vertigo,
    headache, convulsions, increased intracranial pressure with papilledema). It may also effect the immune system
    (immunosuppressant). Repeated large doses of corticosteroids may produce Cushingoid symptoms typical of
    hyperactivity of the adrenal cortex, with moon-face, sometimes hirsutism, buffalo hump, flushing, increased bruising,
    ecchymoses, striae, and acne.
    Medical Conditions Aggravated by Exposure: Hypersensivity to material, ocular herpes simplex, active alcoholism,
    AIDS or HIV infection, heart disease or hypertension, diabetes mellitus, myasthenia gravis, impaired kidney or liver
    function, esophagitis, gastritis or peptic ulcer, chickenpox or measles (including recent exposure), recent intestinal
    surgery, tuberculosis, and system fungal infections.
    Note: The above information came from Physicians GenRx - Drug Information, 1995 or was extrapolated from
    information for Corticosteriods found in a reference called Martindale.

Section 12. Ecological Information
    Not available.
    Not available.
    BOD5 and COD
    Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
    The product itself and its products of degradation are not toxic.
    Toxicity of the Products
    of Biodegradation
    Not available.
    Special Remarks on the
    Products of Biodegradation

Section 13. Disposal Considerations
    Waste must be disposed of in accordance with federal, state and local environmental control
    Waste Disposal

Section 14. Transport Information
    Not a DOT controlled material (United States).
    DO T Cl assi fi cati on
    Not applicable.
    Not applicable.
    Special Provisions for
    DO T (Pi ctograms)

Section 15. Other Regulatory Information and Pictograms
    New Jersey: Prednisone
    Federal and State
    TSCA 8(b) inventory: Prednisone
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause cancer which would require a warning under the statute: No products were found.
    Proposition 65
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause birth defects which would require a warning under the statute: No products were found.
    EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No.
    Other Regulations
    Canada: Listed on Canadian Non-Domestic Substance List (NDSL).
    China: Not listed on National Inventory.
    Japan: Listed on National Inventory (ENCS).
    Korea: Listed on National Inventory (KECI).
    Philippines: Not listed on National Inventory (PICCS).
    Australia: Listed on AICS.
    WHMIS (Canada) Not controlled under WHMIS (Canada).
    Other Classifications
    Not available        Not applicable.    
    DSCL (EEC)
    Health Hazard
    HMIS (U.S.A.)        1 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    1 0 Reactivity
    Reactivity        0    
    Specific hazard
    Personal Protection
    WHMIS (Canada)
    DSCL (Europe)
    ADR (Europe)
    Protective Equipment
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or equivalent.
    CALL (310) 516-8000
    Notice to Reader
    All chemicals may pose unknown hazards and should be used withcaution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials,
    deteriorates, or becomes contaminated, it may pose hazards not mentioned inthis MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based onthe actual


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