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6-propyl-2-thiouracil 51-52-5 MSDS
Name: 4-Hydroxy-2-mercapto-6-propylpyrimidine 98% Material Safety Data Sheet
Synonym: 6-Propyl-2-thiouracil; 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone; 2-Thio-4-oxo-6-propyl-1,3-pyrimidine; 2-Thio-6-propyl-1,3-pyrimidin-4-one; Propacil; Procasil; Propycil; Propyl-Thyracil; Thyreostat II; PTU; 2-Mercapto-4-hydroxy
CAS: 51-52-5
Section 1 - Chemical Product   MSDS Name:4-Hydroxy-2-mercapto-6-propylpyrimidine 98% Material Safety Data Sheet
Synonym:6-Propyl-2-thiouracil; 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone; 2-Thio-4-oxo-6-propyl-1,3-pyrimidine; 2-Thio-6-propyl-1,3-pyrimidin-4-one; Propacil; Procasil; Propycil; Propyl-Thyracil; Thyreostat II; PTU; 2-Mercapto-4-hydroxy

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
51-52-5 Propylthiouracil 98 200-103-2
Hazard Symbols: XN
Risk Phrases: 33

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Danger of cumulative effects.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. If absorbed, may cause symptoms similar to those for ingestion. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed. The most serious reaction to propylthiouracil is agranulocytosis, a severe decrease in the number of white blood cells that are a part of the immune system. Symptoms are sore throat and/or fever, and oral ulcers.
stiffness in the joints, paresthesias, headache, nausea, and loss or depigmentation of hair. Other effects include pulmonary lesions, hepatitis and nephritis.
Inhalation:
May cause respiratory tract irritation. May cause effects similar to those described for ingestion. May be harmful if inhaled.
Chronic:
Prolonged or repeated exposure may cause thyroid inhibition.
Propylthiouracil has induced malignant thyroid tumors in experimental animals. There are no adequate data available to evaluate the carcinogenicity of PTU in humans.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Hormones and antibiotics room. Store protected from light and air.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits CAS# 51-52-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystalline powder
Color: white
Odor: odorless
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 218.00 - 220.00 deg C
Autoignition Temperature: Not available.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: 0.1% @ 20C
Specific Gravity/Density:
Molecular Formula: C7H10N2OS
Molecular Weight: 170.23

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Light, prolonged exposure to air.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 51-52-5: YR1400000 LD50/LC50:
CAS# 51-52-5: Oral, rat: LD50 = 1250 mg/kg.
Carcinogenicity:
Propylthiouracil - California: carcinogen, initial date 1/1/88 NTP: Suspect carcinogen IARC: Group 2B carcinogen Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 33 Danger of cumulative effects.
Safety Phrases:
S 23 Do not inhale gas/fumes/vapour/spray.
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 51-52-5: 1
Canada
CAS# 51-52-5 is listed on Canada's NDSL List.
CAS# 51-52-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 51-52-5 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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