phenobarbital 50-06-6 MSDS

Section 1. Chemical Product and Company Identification
    Phenobarbital
    Common Name/
    Trade Name
    Phenobarbital

Section 3. Hazards Identification
    Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of
    Potential Acute Health
    inhalation. Severe over-exposure can result in death.
    Effects
    CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC.
    Potential Chronic Health
    MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
    Effects
    TERATOGENIC EFFECTS: Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    The substance may be toxic to kidneys, liver, central nervous system (CNS).
    Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to a
    highly toxic material may produce general deterioration of health by an accumulation in one or many human organs.

Section 4. First Aid Measures
    Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
    Eye Contact
    15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention if irritation occurs.
    Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
    Skin Contact
    Not available.
    Serious Skin Contact
    Inhalation        If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get    
    medical attention.
    Serious Inhalation        Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband.    
    If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek
    medical attention.
    If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to
    Ingestion
    an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention
    immediately.
    Not available.
    Serious Ingestion

Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Not available.
    Flash Points
    Not available.
    Flammable Limits
    These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
    Products of Combustion
    Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
    Various Substances
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards in
    Risks of explosion of the product in presence of static discharge: Not available.
    Presence of Various
    Substances
    SMALL FIRE: Use DRY chemical powder.
    Fire Fighting Media
    LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    and Instructions
    When heated to decomposition it emits toxic fumes of nitrogen oxides.
    Special Remarks on
    Fire Hazards
    Not available.
    Special Remarks on
    Explosion Hazards
    Phenobarbital

Section 6. Accidental Release Measures
    Use appropriate tools to put the spilled solid in a convenient waste disposal container.
    Small Spill
    Large Spill        Poisonous solid.    
    Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to reduce
    for assistance on disposal.

Section 7. Handling and Storage
    Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
    Precautions
    ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and
    show the container or the label.
    Keep container tightly closed. Keep container in a cool, well-ventilated area.
    Storage

Section 8. Exposure Controls/Personal Protection
    Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
    Engineering Controls
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.    
    Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to
    avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE
    of a Large Spill
    handling this product.
    Not available.
    Exposure Limits

Section 9. Physical and Chemical Properties
    Solid. (Crystalline solid. Crystalline powder.)        Odorless.    
    Physical state and        O dor    
    appearance
    Bitter. (Slight.)
    Taste
    232.23 g/mole
    Molecular Weight
    White.
    Color
    Not available.
    pH (1% soln/water)
    Not available.
    Boiling Point
    174°C (345.2°F) - 178 C.
    Melting Point
    Not available.
    Critical Temperature
    Not available.
    Specific Gravity
    Not applicable.
    Vapor Pressure
    Not available.
    Vapor Density
    Not available.
    Volatility
    Not available.
    Odor Threshold
    The product is more soluble in oil; log(oil/water) = 1.5
    Water/Oil Dist. Coeff.
    Amphoteric.
    Ionicity (in Water)
    See solubility in water, diethyl ether.
    Dispersion Properties
    Phenobarbital
    Soluble in diethyl ether.
    Solubility
    Very slightly soluble in cold water.
    Solubility in Water: 1 gram is soluble in about 1 liter of water.
    Solubility in Alcohol: 1 gram is soluble in 8 ml of alcohol.
    Solubility in Benzene: 1gram is soluble in 700 ml Benzene.
    Solubility in Ether: 1 gram is soluble in 13 ml Ether.
    Soluble in alkalil hydroxides, and carbonates.

Section 10. Stability and Reactivity Data
    The product is stable.
    Stability
    Not available.
    Instability Temperature
    Conditions of Instability Excess heat, incompatible materials
    Incompatibility with various Reactive with oxidizing agents.
    substances
    Non-corrosive in presence of glass.
    Corrosivity
    Not available.
    Special Remarks on
    Reactivity
    Not available.
    Special Remarks on
    Corrosivity
    Will not occur.
    Polymerization

Section 11. Toxicological Information
    Inhalation. Ingestion.
    Routes of Entry
    Toxicity to Animals        Acute oral toxicity (LD50): 162 mg/kg [Rat].    
    Chronic Effects on Humans CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC.
    MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
    May cause damage to the following organs: kidneys, liver, central nervous system (CNS).
    Hazardous in case of ingestion.
    Other Toxic Effects on
    Slightly hazardous in case of skin contact (irritant), of inhalation.
    Humans
    Not available.
    Special Remarks on
    Toxicity to Animals
    Special Remarks on        May affect genetic material (mutagenic).    
    Chronic Effects on Humans        May cause adverse reproductive effects and birth defects (teratogenic).    
    May cause cancer.
    Excreted in maternal milk in human.
    Acute Potential Health Effects:
    Special Remarks on other
    Skin: May cause skin irritation.
    Toxic Effects on Humans
    Eyes: May cause eye irritation.
    Inhalation: May cause respiratory tract irritation.
    Ingestion: Harmful if swallowed. It is acutely toxic. Phenobarbital is a central nervous system (CNS) depressant.
    Moderate overdoses may resemble alcohol intoxication. It may cause loss of appetite, nausea, vomiting, diarrhea
    and/or constipation. It may cloud perception and distort judgement, induce drowsiness, somnolence, muscle
    contraction or spasticity, lethargy, dizziness, headache, nervousness, insomnia, memory problems, halllucinations,
    irritability, slurred speech, confusion, ataxia, sleep, nightmares and night terrors, depressed reflexes, and anesthesia.
    It may also cause respiratory depression (slow or rapid, shallow breathing), pulmonary edema, hypotension,
    hypothermia, coma, shock, and death from respiratory failure. Respiratory depression may lead to metabilic acidosis
    and hypoxia. Pupils may also be constricted and reactive to light with rapid involuntary movement (nystagmus), and
    in the late stages may be dilated due to hypoxia. It may also affect the kidneys (renal tubular transport). It may also
    cause fever or allergic reaction (dermatitis, and skin rashes)
    Chronic Potential Health Effects:
    Ingestion: Phenobarbital can be addictive and is a drug of abuse. Prolonged and repeated ingestion may cause
    loss of appetite/weight loss, hypocalcemia, and produce central nervous system effects similar to that of acute
    ingestion. It may also produce variable pupilary responses, most often with miosis or with mydriasis in cases of severe
    intoxication. It may also affect the bones (osteomalacia), thyhroid, kidneys, blood (anemia, leukopenia,
    Phenobarbital
    agranulocytosis, macrocytosis, methemglobinemia), brain (degenerative changes), liver and cause liver damage. It
    may also cause allergic reaction.
    Medical Conditions Aggravated by Exposure: Hypersensitivity to material or other barbiturates; liver or kidney
    disease; alcoholism/use of alcohol; use with other CNS depressants.

Section 12. Ecological Information
    Not available.
    Ecotoxicity
    Not available.
    BOD5 and COD
    Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
    arise.
    The products of degradation are less toxic than the product itself.
    Toxicity of the Products
    of Biodegradation
    Not available.
    Special Remarks on the
    Products of Biodegradation

Section 13. Disposal Considerations
    Waste Disposal        Waste must be disposed of in accordance with federal, state and local environmental control    
    regulations.

Section 14. Transport Information
    CLASS 6.1: Poisonous material.
    DO T Cl assi fi cati on
    UNNA: 2811 : Toxic solid, organic, n.o.s. (Phenobarbital) PG: III
    Identification
    Not available.
    Special Provisions for
    Transport
    DO T (Pi ctograms)

Section 15. Other Regulatory Information and Pictograms
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    Federal and State
    cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:
    Regulations
    Phenobarbital
    California prop. 65 (no significant risk level): Phenobarbital: 0.002 mg/day (value)
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause cancer which would require a warning under the statute: Phenobarbital
    Minnesota: Phenobarbital
    Massachusetts RTK: Phenobarbital
    California Director's List of Hazardous Substances: Phenobarbital
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    California
    cause cancer which would require a warning under the statute: Phenobarbital
    Proposition 65
    Warnings
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause birth defects which would require a warning under the statute: No products were found.
    Other Regulations
    Phenobarbital
    OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
    EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No.
    200-007-0).
    Canada: Listed on Canadian Domestic Substance List (DSL).
    China: Not listed on National Inventory.
    Japan: Listed on National Inventory (ENCS).
    Korea: Listed on National Inventory (KECI).
    Philippines: Listed on National Inventory (PICCS).
    Australia: Listed on AICS.
    WHMIS (Canada) CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
    Other Classifications
    CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
    R25- Toxic if swallowed.        S36/37- Wear suitable protective clothing and    
    DSCL (EEC)
    R40- Limited evidence of a        gloves.    
    carcinogenic effect.        S45- In case of accident or if you feel unwell,    
    seek medical advice immediately (show the
    label where possible).
    Health Hazard
    HMIS (U.S.A.)        2 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    2 0 Reactivity
    Health
    Reactivity        0    
    Specific hazard
    Personal Protection
    E
    WHMIS (Canada)
    (Pictograms)
    DSCL (Europe)
    (Pictograms)
    TDG(Canada)
    (Pictograms)
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or equivalent.
    Wear appropriate respirator when ventilation
    is inadequate.
    Safety glasses.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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