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Cortisone acetate 50-04-4 MSDS

Section 1. Chemical Product and Company Identification
    Cortisone acetate
    Common Name/
    Trade Name
    Cortisone acetate

Section 3. Hazards Identification
    Potential Acute Health Effects Slightly hazardous in case of skin contact (irritant, sensitizer), of eye contact (irritant), of ingestion, of
    Potential Chronic Health        Slightly hazardous in case of skin contact (sensitizer).    
    Effects        CARCINOGENIC EFFECTS: Not available.    
    MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
    TERATOGENIC EFFECTS: Not available.

Section 4. First Aid Measures
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for    
    at least 15 minutes. Get medical attention if irritation occurs.
    Skin Contact        Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation    
    Serious Skin Contact        Not available.    
    If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
    Get medical attention.
    Serious Inhalation        Not available.    
    Ingestion        Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an    
    unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen
    tight clothing such as a collar, tie, belt or waistband.
    Serious Ingestion        Not available.    

Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Flash Points        Not available.    
    Flammable Limits        Not available.    
    Products of Combustion        These products are carbon oxides (CO, CO2).    
    Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
    Various Substances
    Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
    of Various Substances        Slightly explosive in presence of open flames and sparks.    
    Fire Fighting Media        SMALL FIRE: Use DRY chemical powder.    
    LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    and Instructions
    Special Remarks on        As with most organic solids, fire is possible at elevated temperatures    
    Fire Hazards
    Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential
    Hazards        dust explosion hazard.    
    Cortisone acetate

Section 6. Accidental Release Measures
    Small Spill        Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by    
    spreading water on the contaminated surface and dispose of according to local and regional authority
    Large Spill        Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading    
    water on the contaminated surface and allow to evacuate through the sanitary system.

Section 7. Handling and Storage
    Precautions        Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not    
    breathe dust. Wear suitable protective clothing. If you feel unwell, seek medical attention and show the label
    when possible.
    Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 25°C (77°F).
    Do not freeze. Sensitive to light. Store in light-resistant containers.

Section 8. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below    
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep
    exposure to airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.    
    Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be
    a Large Spill        used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a    
    specialist BEFORE handling this product.
    Exposure Limits        Not available.    

Section 9. Physical and Chemical Properties
    Physical state and appearance Solid. (Solid crystalline powder.)        Odor        Odorless.    
    Taste        Not available.    
    402.48 g/mole
    Molecular Weight
    Color        White.    
    pH (1% soln/water)        Not applicable.    
    Boiling Point        Not available.    
    Melting Point        235°C (455°F) - 238 C.    
    Not available.
    Critical Temperature
    Specific Gravity        Not available.    
    Not applicable.
    Vapor Pressure
    Vapor Density        Not available.    
    Volatility        Not available.    
    Odor Threshold        Not available.    
    Water/Oil Dist. Coeff.        Not available.    
    Not available.
    Ionicity (in Water)
    Dispersion Properties        See solubility in water, acetone.    
    Partially soluble in acetone.
    Slightly soluble in methanol, diethyl ether.
    Insoluble in cold water.
    Soluble 1 in 350 of alcohol, 1 in 75 of acetone, 1 in 4 of chloroform, 1 in 30 of dioxan.
    Cortisone acetate

Section 10. Stability and Reactivity Data
    The product is stable.
    Instability Temperature        Not available.    
    Conditions of Instability        Excess heat, light    
    Incompatibility with various        Not available.    
    Non-corrosive in presence of glass.
    Special Remarks on        Sensitive to light.    
    Not available.
    Special Remarks on
    Polymerization        Will not occur.    

Section 11. Toxicological Information
    Routes of Entry        Inhalation. Ingestion.    
    Toxicity to Animals        LD50: Not available.    
    LC50: Not available.
    Chronic Effects on Humans MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
    Other Toxic Effects on        Slightly hazardous in case of skin contact (irritant, sensitizer), of ingestion, of inhalation.    
    Special Remarks on        Not available.    
    Toxicity to Animals
    Special Remarks on        May cause adverse reproductive effects and birth defects (teratogenic).    
    Chronic Effects on Humans        May affect genetic material (mutagenic).    
    May cause cancer based on animal test data
    Special Remarks on other        Acute Potential Health Effects:    
    Toxic Effects on Humans        Skin: May cause skin irritation. May cause skin sensitization, an allergic reaction.    
    Eyes: May cause eye irritation.
    Inhalation: May cause respiratory tract irritation.
    Ingestion: May affect metabolism and cause disturbance of electrolyte balance which is manifest in the
    retention of sodium and water, with edema and hypertension, and in the increased excretion of potassium with
    the possibility of hypokalaemic alkalosis. Cardiac faillure may be induced in sensitive individuals.
    Chronic Potential Health Effects:
    Skin: Prolonged or repeated skin contact may cause sensitization, an allergic reaction. it may also cause
    thinning of skin.
    Eyes: Prolonged contact with eyes may affect vision (cataracts). Prolonged or repeated eye contact (e.g
    ophthalmic use of corticosteroids) may also raise intraocular pressure.
    Inhalation/Ingestion: May cause hypersensitivity or sometimes anaphylaxis, an allergic reaction. Prolonged
    or repeated inhalation of corticosteroids may also cause thinning of the skin, and may also affect
    behavior/central nervous system (depression, mania, euphoria and delirium).
    Ingestion: Prolonged or repeated ingestion of corticosteroids lead to peptic ulcers, and may cause acute
    adrenal insufficiency, osteoporosis, effect glucose tolerance, the liver, pancreas (pancreatitis),
    behavior/central nervous system (mental disturbances such as psychosis, euphoria, depression). It may also
    effect the immune system (immunosuppressant), metabolism (effects similar to that of acute ingestion in
    addition to weight loss). Repeated large doses of corticosteroids may produce Cushingoid symptoms typical
    of hyperactivity of the adrenal cortex, with moon-face, sometimes hirsutism, buffalo hump, flushing, increased
    bruising, ecchymoses, striae, and acne.
    Note: The above information was extrapolated from information for Corticosteriods found in a reference called
    Cortisone acetate

Section 12. Ecological Information
    Ecotoxicity        Not available.    
    BOD5 and COD        Not available.    
    Products of Biodegradation        Possibly hazardous short term degradation products are not likely. However, long term degradation products    
    may arise.
    Toxicity of the Products        The product itself and its products of degradation are not toxic.    
    of Biodegradation
    Special Remarks on the        Not available.    
    Products of Biodegradation

Section 13. Disposal Considerations
    Waste Disposal        Waste must be disposed of in accordance with federal, state and local environmental    
    control regulations.

Section 14. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    Not applicable.
    Special Provisions for        Not applicable.    
    DOT (Pictograms)

Section 15. Other Regulatory Information and Pictograms
    No products were found.
    Federal and State
    California        California prop. 65: This product contains the following ingredients for which the State of California has    
    found to cause cancer which would require a warning under the statute: No products were found.
    Proposition 65
    California prop. 65: This product contains the following ingredients for which the State of California has
    found to cause birth defects which would require a warning under the statute: No products were found.
    Other Regulations        EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.    
    WHMIS (Canada) Not controlled under WHMIS (Canada).
    Other Classifications
    DSCL (EEC)        This product is not classified        Not applicable.    
    according to the EU regulations.
    Health Hazard
    HMIS (U.S.A.)        1 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    1 0 Reactivity
    Specific hazard
    Personal Protection
    WHMIS (Canada)
    Cortisone acetate
    DSCL (Europe)
    TDG (Canada)
    ADR (Europe)
    Protective Equipment
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or


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