diazepam 439-14-5 MSDS

Section 1. Chemical Product and Company Identification
    Common Name/
    Trade Name

Section 4. First Aid Measures
    Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
    Eye Contact
    15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention.
    In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove
    Skin Contact
    contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical
    Serious Skin Contact        Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate    
    medical attention.
    Inhalation        If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get    
    medical attention.
    Serious Inhalation        Not available.    
    Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
    unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
    clothing such as a collar, tie, belt or waistband.
    Serious Ingestion        Not available.    

Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Not available.
    Flash Points
    Not available.
    Flammable Limits
    These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds.
    Products of Combustion
    Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
    Non-flammable in presence of shocks.
    Various Substances
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards in
    Risks of explosion of the product in presence of static discharge: Not available.
    Presence of Various
    SMALL FIRE: Use DRY chemical powder.
    Fire Fighting Media
    LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    and Instructions
    Not available.
    Special Remarks on
    Fire Hazards
    Not available.
    Special Remarks on
    Explosion Hazards

Section 6. Accidental Release Measures
    Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading
    Small Spill
    water on the contaminated surface and dispose of according to local and regional authority requirements.
    Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on
    Large Spill
    the contaminated surface and allow to evacuate through the sanitary system.

Section 7. Handling and Storage
    Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk,
    evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not
    breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory
    equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with
    skin and eyes. Keep away from incompatibles such as oxidizing agents, alkalis.
    Light Sensitive. Store in light-resistant containers. Keep container tightly closed. Keep container in a cool,
    well-ventilated area. Do not store above 25°C (77° F).

Section 8. Exposure Controls/Personal Protection
    Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
    Engineering Controls
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
    Personal Protection
    Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to
    avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE
    of a Large Spill
    handling this product.
    Not available.
    Exposure Limits

Section 9. Physical and Chemical Properties
    Solid. (crystalline powder.)        Odorless.    
    Physical state and        O dor    
    Not available.
    284.7 g/mole
    Molecular Weight
    Off-white. Yellow.
    Not available.
    pH (1% soln/water)
    Not available.
    Boiling Point
    132°C (269.6°F)
    Melting Point
    Not available.
    Critical Temperature
    Not available.
    Specific Gravity
    Not applicable.
    Vapor Pressure
    Not available.
    Vapor Density
    Not available.
    Not available.
    Odor Threshold
    The product is more soluble in oil; log(oil/water) = 3
    Water/Oil Dist. Coeff.
    Not available.
    Ionicity (in Water)
    Not available.
    Dispersion Properties
    Very slightly soluble in cold water.
    Insoluble in diethyl ether.
    Solubility in Chloroform is 1 g/ 2 ml chloroform.
    Sparingly soluble in propylene glycol.
    Solubility in ether is 1mg/39 ml ether.
    Solubility in water is 3 mg/1 ml water at 25 C.
    Solubility in alcohol is 62.5 mg/ml alcohol at 25 C

Section 10. Stability and Reactivity Data
    The product is stable.
    Not available.
    Instability Temperature
    Conditions of Instability Excess heat
    Incompatibility with various Reactive with oxidizing agents, alkalis.
    Not available.
    Sensitive to light.
    Special Remarks on
    Incompatible with mineral acid.
    Not available.
    Special Remarks on
    Will not occur.

Section 11. Toxicological Information
    Inhalation. Ingestion.
    Routes of Entry
    Acute oral toxicity (LD50): 48 mg/kg [Mouse].
    Toxicity to Animals
    Acute dermal toxicity (LD50): 800 mg/kg [Mouse].
    CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC.
    Chronic Effects on Humans
    MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
    TERATOGENIC EFFECTS: Classified POSSIBLE for human.
    May cause damage to the following organs: central nervous system (CNS).
    Hazardous in case of ingestion.
    Other Toxic Effects on
    Slightly hazardous in case of skin contact (irritant), of inhalation.
    Special Remarks on        Not available.    
    Toxicity to Animals
    Special Remarks on        It crosses the placenta readily. May cause adverse reproductive effects and birth defects. It has been reported to    
    Chronic Effects on Humans        increase the risk of birth defects when used during the first trimester of pregancy. Chronic use or therapeutic use late    
    in pregnancy may also adversely affect the newborn.
    May cause cancer based on animal data. No human data found.
    Special Remarks on other        Acute Potential Health Effects:    
    Toxic Effects on Humans        Skin and Eyes: May cause skin and eye irritation.    
    Inhalation: May cause respiratory tract irritation.
    Ingestion: Harmful if swallowed. May cause gastrointestinal tract irritation. May affect behavior/central nervous
    system. Symptoms may include drowsiness, dizziness, slurred speech, muscle contraction, clumsiness, anxiety,
    confusion, weakness, mental depression, muscle spasm, false sense of well-being, decreased reflexes coma, seizures,
    shakiness, staggering, delirium, lethargy, hallucinations, excitement and irritability. It may also affect the
    cardiovascular system (fast pounding, irregular heartbeat, hypotension, hypertension, disarthria, cardiac arrest), the
    urinary system, respiratory system (respiratory depression) and may cause changes in vision (diplopia, visual field
    Chronic Potential Health Effects:
    Skin: Prolonged or repeated skin contact may cause allergic reaction.
    Ingestion: Prolonged or repeated ingestion may affect behavior/central nervous system( with symptoms similar to
    acute exposure), endrocrine system, brain, liver (fatty liver degeneration), urinary system, metabolism, blood
    (normocytic anemia) and may cause allergic reaction, and psychological or physical dependence.
    Inhalation: Prolonged or repeated inhalation may cause allergic reaction.

Section 12. Ecological Information
    Not available.
    Not available.
    BOD5 and COD
    Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
    The products of degradation are as toxic as the product itself.
    Toxicity of the Products
    of Biodegradation
    Not available.
    Special Remarks on the
    Products of Biodegradation

Section 13. Disposal Considerations
    Waste must be disposed of in accordance with federal, state and local environmental control
    Waste Disposal

Section 14. Transport Information
    CLASS 6.1: Poisonous material.
    DO T Cl assi fi cati on
    UNNA: 2811 : Toxic solid, organic, n.o.s. (Diazepam) PG: III
    Not available.
    Special Provisions for
    DO T (Pi ctograms)

Section 15. Other Regulatory Information and Pictograms
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    Federal and State
    cause cancer, birth defects or other reproductive harm, which would require a warning under the statute: Diazepam
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause birth defects which would require a warning under the statute: Diazepam
    Massachusetts RTK: Diazepam
    New Jersey: Diazepam
    TSCA 8(b) inventory: Diazepam
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause cancer which would require a warning under the statute: No products were found.
    Proposition 65
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause birth defects which would require a warning under the statute: Diazepam
    OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
    Other Regulations
    EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No.
    Canada: Listed on Canadian Domestic Substance List (DSL).
    China: Not listed on National Inventory.
    Japan: Not listed on National Inventory (ENCS).
    Korea: Listed on National Inventory (KECI).
    Philippines: Not listed on National Inventory (PICCS).
    Australia: Listed on AICS.
    WHMIS (Canada) CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
    Other Classifications
    DSCL (EEC)        R22- Harmful if swallowed.        S2- Keep out of the reach of children.    
    R63- Possible risk of harm to the unborn        S46- If swallowed, seek medical advice    
    child.        immediately and show this container or label.    
    Health Hazard
    HMIS (U.S.A.)        2 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    2 0 Reactivity
    Reactivity        0    
    Specific hazard
    Personal Protection
    WHMIS (Canada)
    DSCL (Europe)
    ADR (Europe)
    Protective Equipment
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or equivalent.
    CALL (310) 516-8000
    Notice to Reader
    All chemicals may pose unknown hazards and should be used withcaution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials,
    deteriorates, or becomes contaminated, it may pose hazards not mentioned inthis MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based onthe actual


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