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Lithium triisobutylhydroborate 38721-52-7 MSDS

Section I.Chemical Product and Company Identification
    Chemical Name        Lithium Tri-sec-butylborohydride    
    (ca. 1.0mol/L THF Soln.)
    Portland OR
    Synonym        Not available.    
    Chemical Formula        LiB[CH(CH3)C2H5]3H    
    CAS Number        38721-52-7    
    109-99-9 (THF)

Section II.        Composition and Information on Ingredients    
    Toxicology Data
    Chemical Name        CAS Number Percent (%)        TLV/PEL    
    Lithium Tri-sec-butylborohydride        ----------        This chemical is classified as Tetrahydrofuran:    
    38721-52-7
    (ca. 1.0mol/L THF Soln.)        a possible carcinogen. There Rat LC50 (inhalation) 21000ppm/m3    
    109-99-9 (THF)
    is no acceptable exposure limit Rat LD50 (oral) 1650mg/kg
    for a carcinogen.        Guinea Pig LD50 (oral) 2300mg/kg    

Section III. Hazards Identification
    Acute Health Effects        Corrosive to skin, eyes, and respiratory system. Liquid or spray mist may produce tissue damage, particularly in mucous    
    membranes of the eyes, mouth and respiratory tract. Skin contact may produce burns. Eye contact can result in corneal
    damage or blindness. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by
    coughing, choking, or shortness of breath. Corrosive materials may cause serious injury if ingested.
    Harmful if ingested or inhaled. Minimize exposure to this material. Severe overexposure can result in injury or death.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
    CARCINOGENIC EFFECTS : Not available.
    Chronic Health Effects
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : TUMORIGENIC EFFECTS:
    Tetrahydrofuran:
    Rat TCLo (inhalation) 18900mg/kg/105 Weeks, intermittent.
    Toxic Effects:
    Tumorigenic- Equivocal tumorigenic agent by RTECS criteria.
    Kidney, Ureter, and Bladder- Kidney tumors.
    Rat TCLo (inhalation) 1800ppm/6 Hours/2 Years, intermittent.
    Tumorigenic- Equivocal tumorigenic agent by RTECS criteria.
    Kidney, Ureter, and Bladder- Tumors.
    Mouse TCLo (inhalation) 113400mg/kg/105 Weeks, intermittent.
    Toxic Effects:
    Tumorigenic- Carcinogenic by RTECS criteria.
    Liver- Tumors.
    DEVELOPMENTAL TOXICITY: REPRODUCTIVE EFFECTS:
    Tetrahydrofuran:
    Toxic Effects:
    Rat TCLo (inhalation) 5000ppm/6 Hours, female, 6-19 Days of pregnancy.
    Effects on Embryo or Fetus- Fetotoxicity.
    Mouse TCLo (inhalation) 1800ppm/6 Hours, female, 6-17 Days of pregnancy.
    Toxic Effects:
    Effects on Fertility- Post-implantation mortality.
    Repeated or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or
    prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial
    infection.
    Continued on Next Page
    Lithium Tri-sec-butylborohydride
    (ca. 1.0mol/L THF Soln.)

Section IV.        First Aid Measures    
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15    
    minutes. Get medical attention.
    Skin Contact        In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing    
    before reuse. Thoroughly clean shoes before reuse. Get medical attention.
    If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
    Inhalation
    waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
    improve.
    DO NOT INDUCE VOMITING. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing,
    Ingestion
    perform mouth-to-mouth resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a
    possible indication that the toxic material was ingested; the absence of such signs, however, is not conclusive.

Section V.        Fire and Explosion Data    
    Auto-Ignition        Not available.    
    Flammability        Flammable.    
    Flash Points        Flammable Limits        Not available.    
    -17°C (1.4°F).
    -21°C (-5.8°F) (THF)
    Combustion Products        These products are toxic carbon oxides (CO, CO2). Some metallic oxides.    
    Fire Hazards
    Not available.
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards
    Risks of explosion of the product in presence of static discharge: Not available.
    Fire Fighting Media
    Flammable liquid.
    and Instructions        DO NOT USE WATER.    
    SMALL FIRE: Use DRY chemical powder.
    LARGE FIRE: Use DRY chemical powder.
    Consult with local fire authorities before attempting large scale fire-fighting operations.

Section VI.        Accidental Release Measures    
    Spill Cleanup        Water-reactive material. Flammable liquid. Corrosive liquid. Possible carcinogenic material. Harmful material. May    
    form explosive peroxides. Do not distill to dryness. Air sensitive material.
    Instructions
    Keep away from heat. Mechanical exhaust required. Stop leak if without risk. Absorb with DRY earth, sand or other
    non-combustible material. DO NOT get water inside container. DO NOT touch spilled material. Use water spray curtain
    to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Consult federal, state,
    and/or local authorities for assistance on disposal.

Section VII. Handling and Storage
    Handling and Storage        WATER-REACTIVE. FLAMMABLE. CORROSIVE. POSSIBLE CARCINOGEN. HARMFUL. MAY FORM EXPLOSIVE    
    PEROXIDES. DO NOT DISTILL TO DRYNESS. AIR SENSITIVE. Keep under inert atmosphere. Keep container dry.
    Information
    Do not breathe gas/fumes/ vapor/spray. Never add water to this product. Wear suitable protective clothing. If you feel
    unwell, seek medical attention and show the label when possible. Treat symptomatically and supportively.
    Always store away from incompatible compounds such as oxidizing agents, acids.

Section VIII. Exposure Controls/Personal Protection
    Engineering Controls        Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their    
    respective threshold limit value. Ensure that eyewash station and safety shower is proximal to the work-station location.
    Face shield. Lab coat. Vapor respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a
    Personal Protection
    specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
    Exposure Limits        This chemical is classified as a possible carcinogen. There is no acceptable exposure limit for a carcinogen.    

Section IX. Physical and Chemical Properties
    Physical state @ 20°C        Liquid. (Colorless to light yellow.)        Solubility    
    Not available.
    0.890 (water=1)
    Specific Gravity
    Molecular Weight        190.10        Partition Coefficient    
    Not available.
    Boiling Point        Not available.        Vapor Pressure        Not available.    
    Not available.        Not available.    
    Melting Point        Vapor Density    
    Not available.        Not available.    
    Refractive Index        Volatility    
    Not available.
    Critical Temperature        Not available.        Odor    
    Viscosity        Not available.        Taste        Not available.    
    Continued on Next Page
    Lithium Tri-sec-butylborohydride
    (ca. 1.0mol/L THF Soln.)

Section X.        Stability and Reactivity Data    
    Stability    
This material is stable if stored under proper conditions. (See Section VII for instructions)    
    Conditions of Instability        Air sensitive. Avoid excessive heat and light.    
    Incompatibilities
    Reactive with oxidizing agents, acids, alcohols, water, oxygen.
    The product REACTS violently with water to emit FLAMMABLE BUT NON TOXIC GASES.

Section XI. Toxicological Information
    RTECS Number        OJ5585000    
    Eye Contact. Ingestion. Inhalation. Skin contact.
    Routes of Exposure
    Tetrahydrofuran:
    Toxicity Data
    Rat LC50 (inhalation) 21000ppm/m3
    Rat LD50 (oral) 1650mg/kg
    Guinea Pig LD50 (oral) 2300mg/kg
    CARCINOGENIC EFFECTS : Not available.
    Chronic Toxic Effects
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : TUMORIGENIC EFFECTS:
    Tetrahydrofuran:
    Rat TCLo (inhalation) 18900mg/kg/105 Weeks, intermittent.
    Toxic Effects:
    Tumorigenic- Equivocal tumorigenic agent by RTECS criteria.
    Kidney, Ureter, and Bladder- Kidney tumors.
    Rat TCLo (inhalation) 1800ppm/6 Hours/2 Years, intermittent.
    Tumorigenic- Equivocal tumorigenic agent by RTECS criteria.
    Kidney, Ureter, and Bladder- Tumors.
    Mouse TCLo (inhalation) 113400mg/kg/105 Weeks, intermittent.
    Toxic Effects:
    Tumorigenic- Carcinogenic by RTECS criteria.
    Liver- Tumors.
    DEVELOPMENTAL TOXICITY: REPRODUCTIVE EFFECTS:
    Tetrahydrofuran:
    Toxic Effects:
    Rat TCLo (inhalation) 5000ppm/6 Hours, female, 6-19 Days of pregnancy.
    Effects on Embryo or Fetus- Fetotoxicity.
    Mouse TCLo (inhalation) 1800ppm/6 Hours, female, 6-17 Days of pregnancy.
    Toxic Effects:
    Effects on Fertility- Post-implantation mortality.
    Repeated or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or
    prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection.
    Acute Toxic Effects        Corrosive to skin, eyes, and respiratory system. Liquid or spray mist may produce tissue damage, particularly in mucous    
    membranes of the eyes, mouth and respiratory tract. Skin contact may produce burns. Eye contact can result in corneal
    damage or blindness. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by
    coughing, choking, or shortness of breath. Corrosive materials may cause serious injury if ingested.
    Harmful if ingested or inhaled. Minimize exposure to this material. Severe overexposure can result in injury or death.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

Section XII.        Ecological Information    
    Ecotoxicity        Not available.    
    Tetrahydrofuran's production and use as a solvent for natural and synthetic resins and in organic synthesis may result in
    Environmental Fate
    its release to the environment through various waste streams. If released to air, a vapor pressure of 162 mm Hg at 25 deg
    C indicates tetrahydrofuran will exist solely as a vapor in the ambient atmosphere. Vapor-phase tetrahydrofuran will be
    degraded in the atmosphere by reaction with photochemically-produced hydroxyl and nitrate radicals; the half-life for these
    reactions in air are about 1 and 3 days, respectively. If released to soil, tetrahydrofuran is expected to have very high
    mobility based upon Koc values of 23 and 18. Volatilization from moist soil surfaces is expected to be an important fate
    process based upon a Henry's Law constant of 7.1X10-5 atm-cu m/mole. Tetrahydrofuran may volatilize from dry soil
    surfaces based upon its vapor pressure. Tetrahydrofuran added to surface soil had an abiotic half-life of 5.7 days. If
    released into water, tetrahydrofuran is not expected to adsorb to suspended solids and sediment based upon the Koc.
    Tetrahydrofuran is expected to biodegrade under aerobic conditions but may be resistant to biodegradation in anaerobic
    environments. In the modified MITI screening test, tetrahydrofuran at 30 mg/l was completely biodegraded in 14 days
    using an activated sludge inoculum. Tetrahydrofuran at 50 mg C/l was resistant to anaerobic biodegradation with a lag
    period of greater than 60 days using a primary digesting sludge as an inoculum. Volatilization from water surfaces is
    expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization
    half-lives for a model river and model lake are 13.1 hrs and 6.6 days, respectively. An estimated BCF of 3 suggests the
    potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to occur due to the lack of
    hydrolyzable functional groups. Occupational exposure to tetrahydrofuran may occur through inhalation and dermal
    contact with this compound at workplaces where tetrahydrofuran is produced or used. (HSDB)
    Continued on Next Page
    Lithium Tri-sec-butylborohydride
    (ca. 1.0mol/L THF Soln.)

Section XIII.        Disposal Considerations    
    Waste Disposal        Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a    
    combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
    federal, state and local regulations when disposing of the substance.

Section XIV. Transport Information
    DOT Classification        DOT CLASS 4.3: Dangerous when wet    
    DOT CLASS 3: Flammable liquid
    PIN Number
    Proper Shipping Name        Organometallic substance, liquid, water-reactive, flammable    
    Packing Group (PG)        I    
    DOT Pictograms
    DANGEROUS        W HEN    
    W ET
    4

Section XV. Other Regulatory Information and Pictograms
    TSCA Chemical Inventory        This compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list.    
    (EPA)
    WHMIS Classification
    CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).
    CLASS E: Corrosive liquid.
    (Canada)
    EINECS Number (EEC)        254-101-1    
    203-726-8 (THF)
    EEC Risk Statements        R10- Flammable.    
    R14/15- Reacts violently with water, liberating highly flammable gases.
    R17- Spontaneously flammable in air. 18- In use, may form flammable/explosive vapor-air mixture.
    R19- May form explosive peroxides.
    R20/21/22- Harmful by inhalation, in contact with skin and if swallowed.
    R34- Causes burns.
    R45- May cause cancer.
    Japanese Regulatory Data


SECTION 16 - ADDITIONAL INFORMATION
N/A

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