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aristolochic acid 313-67-7 MSDS
Name: Aristolochic acid mixture of I and II (approx. 1:1) Material Safety Data Sheet
Synonym: 3,4-Methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid mixed with 3,4-Methylenedioxy-10-nitro-1-phenanthrenecarboxylic acid
CAS: 313-67-7
Section 1 - Chemical Product   MSDS Name:Aristolochic acid mixture of I and II (approx. 1:1) Material Safety Data Sheet
Synonym:3,4-Methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid mixed with 3,4-Methylenedioxy-10-nitro-1-phenanthrenecarboxylic acid

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
313-67-7 Aristolochic acid I 50 206-238-3
Hazard Symbols: T
Risk Phrases: 23/24/25 36/37/38 45 68

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin. May cause cancer.Possible risk of irreversible effects.Cancer suspect agent.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
May cause kidney damage.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. May cause kidney damage.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container. Store at room temperature or below.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 313-67-7: CAS# 475-80-9: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Powder
Color: orange-yellow
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 260-265 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 281-286 deg C
Solubility in water: Slightly soluble.
Specific Gravity/Density:
Molecular Formula: C17H11NO7
Molecular Weight: 341.27

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 313-67-7: CF3325000 CAS# 475-80-9: SF8281600 LD50/LC50:
CAS# 313-67-7: Oral, mouse: LD50 = 55900 ug/kg; Oral, rat: LD50 = 184 mg/kg.
CAS# 475-80-9.
Carcinogenicity:
Aristolochic acid I - California: carcinogen, initial date 7/9/04 (listed as Aristolochic ac IARC: Group 2A carcinogen (listed as Aristolochic acids (natural Aristolochic acid II - California: carcinogen, initial date 7/9/04 (listed as Aristolochic ac IARC: Group 2A carcinogen (listed as Aristolochic acids (natural Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: ALKALOID SALTS, SOLID, N.O.S.*
Hazard Class: 6.1
UN Number: 1544
Packing Group: I
IMO
Shipping Name: ALKALOID SALTS, SOLID, N.O.S.
Hazard Class: 6.1
UN Number: 1544
Packing Group: I
RID/ADR
Shipping Name: ALKALOID SALTS, SOLID, N.O.S.
Hazard Class: 6.1
UN Number: 1544
Packing group: I

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 45 May cause cancer.
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
R 68 Possible risk of irreversible effects.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 313-67-7: No information available.
CAS# 475-80-9: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 313-67-7 is not listed on Canada's Ingredient Disclosure List.
CAS# 475-80-9 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 313-67-7 is not listed on the TSCA inventory.
It is for research and development use only.
CAS# 475-80-9 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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