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3-Isocyanatopropyltriethoxysilane 24801-88-5 MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : 3-(Triethoxysilyl)propyl isocyanate    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
    CAS-No.        : 24801-88-5    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Acute toxicity, Oral (Category 4), H302
    Acute toxicity, Inhalation (Category 1), H330
    Acute toxicity, Dermal (Category 4), H312
    Skin corrosion (Category 1B), H314
    Respiratory sensitisation (Category 1), H334
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    T+ Very toxic        R26    
    C Corrosive        R34    
    Xn Harmful        R21/22, R42    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Signal word        Danger    
    Hazard statement(s)
    H302 + H312        Harmful if swallowed or in contact with skin    
    H314        Causes severe skin burns and eye damage.    
    H330        Fatal if inhaled.    
    H334        May cause allergy or asthma symptoms or breathing difficulties if inhaled.    
    Precautionary statement(s)
    P260        Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.    
    P280        Wear protective gloves/ protective clothing/ eye protection/ face    
    P284        Wear respiratory protection.    
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    P310        Immediately call a POISON CENTER or doctor/ physician.    
    Supplemental Hazard        none    
  Other hazards
    This substance/mixture contains no components considered to be either persistent, bioaccumulative and
    toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients
    Synonyms        : Triethoxy(3-isocyanatopropyl)silane    
    Formula        : C10H21NO4Si    
    Molecular weight        : 247,36 g/mol    
    CAS-No.        : 24801-88-5    
    EC-No.        : 246-467-6    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
    CAS-No.        24801-88-5        Acute Tox. 4; Acute Tox. 1;        <= 100 %    
    EC-No.        246-467-6        Acute Tox. 4; Skin Corr. 1B;    
    Resp. Sens. 1; H302 + H312,
    H314, H330, H334
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
    CAS-No.        24801-88-5        T+, R26 - R21/22 - R34 - R42 <= 100 %    
    EC-No.        246-467-6    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take
    victim immediately to hospital. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    No data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides, Nitrogen oxides (NOx), silicon oxides
  Advice for firefighters
    Wear self-contained breathing apparatus for firefighting if necessary.
  Further information
    Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove
    all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form
    explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13). Keep in suitable, closed
    containers for disposal.
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
    Store under inert gas. Moisture sensitive.
    Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
    the product.
  Personal protective equipment
  Eye/face protection
    Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection
    tested and approved under appropriate government standards such as NIOSH (US) or EN
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Full contact
    Material: butyl-rubber
    Minimum layer thickness: 0,3 mm
    Break through time: 480 min
    Material tested:Butoject® (KCL 897 / Z677647, Size M)
    Splash contact
    Material: Nitrile rubber
    Minimum layer thickness: 0,2 mm
    Break through time: 30 min
    Material tested:Dermatril® P (KCL 743 / Z677388, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    Complete suit protecting against chemicals, The type of protective equipment must be selected
    according to the concentration and amount of the dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: liquid    
    b) Odour        No data available    
    c) Odour Threshold        No data available    
    d) pH        No data available    
    e) Melting point/freezing        No data available    
    f) Initial boiling point and 283 °C - lit.
    boiling range
    g) Flash point        77 °C - closed cup    
    h) Evaporation rate        No data available    
    i) Flammability (solid, gas) No data available
    j) Upper/lower        No data available    
    flammability or
    explosive limits
    k) Vapour pressure        No data available    
    l) Vapour density        No data available    
    m) Relative density        0,999 g/mL at 25 °C    
    n) Water solubility        No data available    
    o) Partition coefficient: n- No data available
    p) Auto-ignition        No data available    
    q) Decomposition        No data available    
    r) Viscosity        No data available    
    s) Explosive properties        No data available    
    t) Oxidizing properties        No data available    
  Other safety information
    No data available

SECTION 10: Stability and reactivity
    No data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    No data available
  Conditions to avoid
    Heat, flames and sparks.
  Incompatible materials
    Oxidizing agents, Alcohols
  Hazardous decomposition products
    Other decomposition products - No data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LD50 Oral - Rat - 707 mg/kg
    Remarks: Behavioral:Somnolence (general depressed activity). Lungs, Thorax, or Respiration:Dyspnea.
    Gastrointestinal:Other changes.
    LC50 Inhalation - Rat - 4 h - 360 mg/m3
    Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Conjunctive irritation.
    Lungs, Thorax, or Respiration:Fibrosis, focal (pneumoconiosis). Blood: Hemorrhage.
    LD50 Dermal - Rabbit - 1.260 mg/kg
    Remarks: Behavioral:Irritability. Lungs, Thorax, or Respiration:Acute pulmonary edema. Prolonged skin
    contact may cause skin irritation and/or dermatitis.
  Skin corrosion/irritation
    No data available
  Serious eye damage/eye irritation
    Eyes - Rabbit
    Result: Severe eye irritation
  Respiratory or skin sensitisation
  Germ cell mutagenicity
    No data available
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
  Reproductive toxicity
    No data available
  Specific target organ toxicity - single exposure
    No data available
  Specific target organ toxicity - repeated exposure
    No data available
  Aspiration hazard
    No data available
  Additional Information
    RTECS: VV6691000
    Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and
    skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi,
    pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath,
    Headache, Nausea
    To the best of our knowledge, the chemical, physical, and toxicological properties have not been
    thoroughly investigated.

SECTION 12: Ecological information
    No data available
  Persistence and degradability
    No data available
  Bioaccumulative potential
    No data available
  Mobility in soil
    No data available
  Results of PBT and vPvB assessment
    This substance/mixture contains no components considered to be either persistent, bioaccumulative and
    toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
  Other adverse effects
    No data available

SECTION 13: Disposal considerations
  Waste treatment methods
    This combustible material may be burned in a chemical incinerator equipped with an afterburner and
    scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 3390        IMDG: 3390        IATA: 3390    
  UN proper shipping name
    ADR/RID: TOXIC BY INHALATION LIQUID, CORROSIVE, N.O.S. (Triethoxy(3-isocyanatopropyl)silane)
    IMDG: TOXIC BY INHALATION LIQUID, CORROSIVE, N.O.S. (Triethoxy(3-isocyanatopropyl)silane)
    IATA:        Toxic by inhalation liquid, corrosive, n.o.s. (Triethoxy(3-isocyanatopropyl)silane)    
    Passenger Aircraft: Not permitted for transport
    Cargo Aircraft: Not permitted for transport
  Transport hazard class(es)
    ADR/RID: 6.1 (8)        IMDG: 6.1 (8)        IATA: 6.1 (8)    
  Packaging group
    ADR/RID: I        IMDG: I        IATA: -    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    No data available

SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
    No data available
  Chemical Safety Assessment
    For this product a chemical safety assessment was not carried out

SECTION 16: Other information
  Full text of H-Statements referred to under sections 2 and 3.
    Acute Tox.        Acute toxicity    
    H302        Harmful if swallowed.    
    H302 + H312        Harmful if swallowed or in contact with skin    
    H312        Harmful in contact with skin.    
    H314        Causes severe skin burns and eye damage.    
    H330        Fatal if inhaled.    
    H334        May cause allergy or asthma symptoms or breathing difficulties if inhaled.    
    Resp. Sens.        Respiratory sensitisation    
    Skin Corr.        Skin corrosion    
  Full text of R-phrases referred to under sections 2 and 3
    T+        Very toxic    
    R21/22        Harmful in contact with skin and if swallowed.    
    R26        Very toxic by inhalation.    
    R34        Causes burns.    
    R42        May cause sensitisation by inhalation.    
  Further information
    Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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