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1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole 19387-91-8 MSDS
    Version 1.2
    Regulation (EC) No 1907/2006

    1 - Product and Company Information

    Product Name        TINIDAZOLE    

    2 - Hazards Identification

    SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
    Harmful by inhalation, in contact with skin and if swallowed.
    Limited evidence of a carcinogenic effect.

    3 - Composition/Information on Ingredients

    Product Name        CAS #        EC no        Annex I    
    Index Number
    TINIDAZOLE        19387-91-8 243-014-4 None    
    Formula        C8H13N3O4S    
    Molecular Weight 247,3000 AMU
    Synonyms        Bioshik * CP 12574 * Ethyl    
    (2-(2-methyl-5-nitro-1-imidazolyl)ethyl)sulfone
    *
    1-(2-(Ethylsulfonyl)-ethyl)-2-methyl-5-nitroimida
    zole * Fasigin * Fasigyn * 1H-Imidazole,
    1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro- *
    Pletil * Simplotan * Sorquetan * Tinidazol *
    Tinidazole * Tricolam * Trimonase

    4 - First Aid Measures

    AFTER INHALATION
    If inhaled, remove to fresh air. If not breathing give
    artificial respiration. If breathing is difficult, give oxygen.
    AFTER SKIN CONTACT
    In case of skin contact, flush with copious amounts of water for
    at least 15 minutes. Remove contaminated clothing and shoes.
    Call a physician.
    AFTER EYE CONTACT
    In case of contact with eyes, flush with copious amounts of
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    water for at least 15 minutes. Assure adequate flushing by
    separating the eyelids with fingers. Call a physician.
    AFTER INGESTION
    If swallowed, wash out mouth with water provided person is
    conscious. Call a physician.

    5 - Fire Fighting Measures

    EXTINGUISHING MEDIA
    Suitable: Water spray. Carbon dioxide, dry chemical powder, or
    appropriate foam.
    SPECIAL RISKS
    Specific Hazard(s): Emits toxic fumes under fire conditions.
    SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
    Wear self-contained breathing apparatus and protective clothing
    to prevent contact with skin and eyes.

    6 - Accidental Release Measures

    PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
    Evacuate area.
    PROCEDURE(S) OF PERSONAL PRECAUTION(S)
    Wear self-contained breathing apparatus, rubber boots, and heavy
    rubber gloves.
    METHODS FOR CLEANING UP
    Sweep up, place in a bag and hold for waste disposal. Avoid
    raising dust. Ventilate area and wash spill site after material
    pickup is complete.

    7 - Handling and Storage

    HANDLING
    Directions for Safe Handling: Do not breathe dust. Avoid contact
    with eyes, skin, and clothing. Avoid prolonged or repeated
    exposure.
    STORAGE
    Conditions of Storage: Keep tightly closed.

    8 - Exposure Controls / Personal Protection

    ENGINEERING CONTROLS
    Safety shower and eye bath. Mechanical exhaust required.
    GENERAL HYGIENE MEASURES
    Wash thoroughly after handling.
    PERSONAL PROTECTIVE EQUIPMENT
    Respiratory Protection: Use respirators and components tested and
    approved under appropriate government standards such as NIOSH (US)
    or CEN (EU). Where risk assessment shows air-purifying respirators
    are appropriate use a dust mask type N95 (US) or type P1 (EN 143)
    respirator.
    Hand Protection: Compatible chemical-resistant gloves.
    Eye Protection: Chemical safety goggles.
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    9 - Physical and Chemical Properties

    Appearance        Physical State: Solid    
    Property        Value        At Temperature or Pressure    
    pH N/A
    BP/BP Range        N/A    
    MP/MP Range        N/A    
    Flash Point        N/A    
    Flammability        N/A    
    Autoignition Temp        N/A    
    Oxidizing Properties N/A
    Explosive Properties N/A
    Explosion Limits        N/A    
    Vapor Pressure        N/A    
    Partition Coefficient N/A
    Viscosity        N/A    
    Vapor Density        N/A    
    Saturated Vapor Conc. N/A
    Evaporation Rate        N/A    
    Bulk Density        N/A    
    Decomposition Temp.        N/A    
    Solvent Content        N/A    
    Water Content        N/A    
    Surface Tension        N/A    
    Conductivity        N/A    
    Miscellaneous Data        N/A    
    Solubility        N/A    

    10 - Stability and Reactivity

    STABILITY
    Stable: Stable.
    Materials to Avoid: Strong oxidizing agents.
    HAZARDOUS DECOMPOSITION PRODUCTS
    Hazardous Decomposition Products: Carbon monoxide, carbon dioxide,
    and nitrogen oxides.
    HAZARDOUS POLYMERIZATION
    Hazardous Polymerization: Will not occur

    11 - Toxicological Information

    RTECS NUMBER: NI6255000
    ACUTE TOXICITY
    LD50
    Oral
    Rat
    2710,000000 mg/kg
    Remarks: Lungs, Thorax, or Respiration:Cyanosis.
    Behavioral:Convulsions or effect on seizure threshold.
    Gastrointestinal:Changes in structure or function of salivary
    glands.
    LD50
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    Intraperitoneal
    Rat
    2720 MG/KG
    Remarks: Behavioral:Convulsions or effect on seizure threshold.
    Lungs, Thorax, or Respiration:Cyanosis. Gastrointestinal:Changes
    in structure or function of salivary glands.
    LD50
    Subcutaneous
    Rat
    3 GM/KG
    Remarks: Behavioral:Convulsions or effect on seizure threshold.
    Lungs, Thorax, or Respiration:Cyanosis. Gastrointestinal:Changes
    in structure or function of salivary glands.
    LD50
    Intravenous
    Rat
    >250 MG/KG
    Remarks: Lungs, Thorax, or Respiration:Cyanosis.
    Behavioral:Somnolence (general depressed activity).
    Behavioral:Convulsions or effect on seizure threshold.
    LD50
    Oral
    Mouse
    3200,000000 mg/kg
    Remarks: Behavioral:Somnolence (general depressed activity).
    Behavioral:Tremor. Behavioral:Ataxia.
    LD50
    Intraperitoneal
    Mouse
    2730 MG/KG
    Remarks: Behavioral:Convulsions or effect on seizure threshold.
    Lungs, Thorax, or Respiration:Cyanosis. Gastrointestinal:Changes
    in structure or function of salivary glands.
    LD50
    Subcutaneous
    Mouse
    3940 MG/KG
    Remarks: Behavioral:Convulsions or effect on seizure threshold.
    Lungs, Thorax, or Respiration:Cyanosis. Gastrointestinal:Changes
    in structure or function of salivary glands.
    LD50
    Intravenous
    Mouse
    >250 MG/KG
    Remarks: Behavioral:Somnolence (general depressed activity).
    Behavioral:Convulsions or effect on seizure threshold. Lungs,
    Thorax, or Respiration:Cyanosis.
    SIGNS AND SYMPTOMS OF EXPOSURE
    Exposure can cause: Urticaria, flushing, pruritus, dysuria,
    cystitis, dryness of the mouth, dizziness, vertigo, and very
    rarely, incoordination and ataxia, a metallic, sharp, unpleasant
    taste, furry tongue, glossitis, and stomatitis. Exposure to
    and/or consumption of alcohol may increase toxic effects.
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    Gastrointestinal disturbances. Nausea, headache, and vomiting.
    To the best of our knowledge, the chemical, physical, and
    toxicological properties have not been thoroughly investigated.
    ROUTE OF EXPOSURE
    Skin Contact: May cause skin irritation.
    Skin Absorption: Harmful if absorbed through skin.
    Eye Contact: May cause eye irritation.
    Inhalation: Harmful if inhaled. Material may be irritating to
    mucous membranes and upper respiratory tract.
    Ingestion: Harmful if swallowed.
    CHRONIC EXPOSURE - MUTAGEN
    Mouse
    50 MG/KG
    Intraperitoneal
    Micronucleus test
    CHRONIC EXPOSURE - TERATOGEN
    Species: Rat
    Dose: 3 GM/KG
    Route of Application: Oral
    Exposure Time: (9-14D PREG)
    Result: Effects on Embryo or Fetus: Fetal death.
    Species: Rat
    Dose: 12 GM/KG
    Route of Application: Oral
    Exposure Time: (9-14D PREG)
    Result: Specific Developmental Abnormalities: Musculoskeletal
    system.
    Species: Mouse
    Dose: 3 GM/KG
    Route of Application: Oral
    Exposure Time: (7-12D PREG)
    Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
    e.g., stunted fetus).
    Species: Mouse
    Dose: 15 GM/KG
    Route of Application: Oral
    Exposure Time: (7-12D PREG)
    Result: Specific Developmental Abnormalities: Musculoskeletal
    system.

    12 - Ecological Information

    No data available.

    13 - Disposal Considerations

    SUBSTANCE DISPOSAL
    Contact a licensed professional waste disposal service to dispose
    of this material. Dissolve or mix the material with a combustible
    solvent and burn in a chemical incinerator equipped with an
    afterburner and scrubber. Observe all federal, state, and local
    environmental regulations.
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    14 - Transport Information

    RID/ADR
    Non-hazardous for road transport.
    IMDG
    Non-hazardous for sea transport.
    IATA
    Non-hazardous for air transport.

    15 - Regulatory Information

    CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
    INDICATION OF DANGER: Xn
    Harmful.
    R-PHRASES: 20/21/22-40
    Harmful by inhalation, in contact with skin and if swallowed.
    Limited evidence of a carcinogenic effect.
    S-PHRASES: 26-36
    In case of contact with eyes, rinse immediately with plenty of
    water and seek medical advice. Wear suitable protective
    clothing.
    COUNTRY SPECIFIC INFORMATION
    Germany
    WGK: 3
    Self-Classification

    16 - Other Information

    WARRANTY
    The above information is believed to be correct but does not
    purport to be all inclusive and shall be used only as a guide. The
    information in this document is based on the present state of our
    knowledge and is applicable to the product with regard to
    appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Inc.,
    shall not be held liable for any damage resulting from handling or
    from contact with the above product. See reverse side of invoice
    or packing slip for additional terms and conditions of sale.
    Copyright 2010 Co. License granted to make
    unlimitedpaper copies for internal use only.
    DISCLAIMER
    For R&D use only. Not for drug, household or other uses.
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SECTION 16 - ADDITIONAL INFORMATION
N/A

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