ketamine hydrochloride 1867-66-9 MSDS

Section 1. Chemical Product and Company Identification
    Ketamine Hydrochloride        Catalog    
    Common Name/
    Trade Name
    CAS#        1867-66-9    
    RTECS        GW1400000    
    TSCA        TSCA 8(b) inventory: No    
    products were found.
    Commercial Name(s)        Not available.    
    CI# Not available.
    Synonym        [2-(2-Chlorophenyl)-2-(methylamino)-cyclohexanone Hydrochloride]    
    Ketamine Hydrochloride
    Chemical Name
    Chemical Family        Not available.        CALL (310) 516-8000    
    C13-H16-Cl-N-O. HCL
    Chemical Formula

Section 2.Composition and Information on Ingredients
    Exposure Limits
    TWA (mg/m3)        STEL (mg/m3) CEIL (mg/m3)    
    Name        CAS #        % by Weight    
    1) Ketamine Hydrochloride        1867-66-9        100    
    Toxicological Data        Ketamine Hydrochloride:    
    on Ingredients        ORAL (LD50):        Acute: 447 mg/kg [Rat]. 617 mg/kg [Mouse].    

Section 3. Hazards Identification
    Potential Acute Health Effects Hazardous in case of skin contact (irritant, sensitizer), of eye contact (irritant), of ingestion, of inhalation (lung
    Potential Chronic Health        CARCINOGENIC EFFECTS: Not available.    
    MUTAGENIC EFFECTS: Not available.
    TERATOGENIC EFFECTS: Not available.
    DEVELOPMENTAL TOXICITY: Classified Development toxin [POSSIBLE].
    The substance is toxic to lungs, peripheral nervous system, cardiovascular system, upper respiratory tract.
    Repeated or prolonged exposure to the substance can produce target organs damage.
    Ketamine Hydrochloride

Section 4. First Aid Measures
    Eye Contact        Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes,    
    keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention.
    Skin Contact        After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin    
    with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.
    Cover the irritated skin with an emollient. If irritation persists, seek medical attention.
    Serious Skin Contact        Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate    
    medical attention.
    Inhalation        Allow the victim to rest in a well ventilated area. Seek immediate medical attention.    
    Serious Inhalation        Not available.    
    Ingestion        Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible    
    indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen
    tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
    resuscitation. Seek immediate medical attention.
    Serious Ingestion        Not available.    

Section 5. Fire and Explosion Data
    Flammability of the Product Non-flammable.
    Auto-Ignition Temperature Not applicable.
    Flash Points        Not applicable.    
    Flammable Limits        Not applicable.    
    Products of Combustion        These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds.    
    Fire Hazards in Presence of Flammable in presence of open flames and sparks, of heat.
    Various Substances
    Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
    of Various Substances        Risks of explosion of the product in presence of static discharge: Not available.    
    Fire Fighting Media        SMALL FIRE: Use DRY chemical powder.    
    LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    and Instructions
    Special Remarks on        Not available.    
    Fire Hazards
    Special Remarks on Explosion Not available.

Section 6. Accidental Release Measures
    Small Spill        Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by    
    spreading water on the contaminated surface and dispose of according to local and regional authority
    Large Spill        Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary    
    Ketamine Hydrochloride

Section 7. Handling and Storage
    Precautions        Keep locked up Do not ingest. Do not breathe gas/fumes/ vapour/spray. Wear suitable protective clothing In    
    case of insufficient ventilation, wear suitable respiratory equipment If ingested, seek medical advice immediately
    and show the container or the label. Keep container tightly closed and in a well-ventilated place. Avoid contact
    with skin and eyes
    Storage        Carcinogenic, teratogenic or mutagenic materials should be stored in a separate locked safety storage cabinet or    

Section 8. Exposure Controls/Personal Protection
    Engineering Controls        No special ventilation requirements.    
    Personal Protection        Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent.    
    Personal Protection in Case of Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be
    a Large Spill        used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist    
    BEFORE handling this product.
    Exposure Limits        Not available.    

Section 9. Physical and Chemical Properties
    Physical state and appearance Not available.        Odor        Not available.    
    Taste        Not available.    
    Molecular Weight        274.2 g/mole    
    Not available.
    pH (1% soln/water)
    Boiling Point        Not available.    
    262.5°C (504.5°F)
    Melting Point
    Critical Temperature        Not available.    
    Specific Gravity        Not available.    
    Vapor Pressure        Not available.    
    Vapor Density        Not available.    
    Volatility        Not available.    
    Odor Threshold        Not available.    
    Not available.
    Water/Oil Dist. Coeff.
    Ionicity (in Water)        Not available.    
    Dispersion Properties        Partially dispersed in hot water.    
    Very slightly dispersed in cold water, methanol.
    Solubility        Partially soluble in hot water.    
    Very slightly soluble in cold water, methanol, n-octanol.

Section 10. Stability and Reactivity Data
    Stability        The product is stable.    
    Instability Temperature        Not available.    
    Conditions of Instability        Not available.    
    Incompatibility with various        Slightly reactive to reactive with oxidizing agents.    
    Corrosivity        Non-corrosive in presence of glass.    
    Ketamine Hydrochloride
    Special Remarks on        Not available.    
    Not available.
    Special Remarks on
    Polymerization        No.    

Section 11. Toxicological Information
    Routes of Entry        Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.    
    Toxicity to Animals        Acute oral toxicity (LD50): 447 mg/kg [Rat].    
    Chronic Effects on Humans        DEVELOPMENTAL TOXICITY: Classified Development toxin [POSSIBLE].    
    The substance is toxic to lungs, peripheral nervous system, cardiovascular system, upper respiratory tract.
    Other Toxic Effects on        Hazardous in case of skin contact (irritant, sensitizer), of ingestion, of inhalation (lung irritant).    
    Special Remarks on
    Not available.
    Toxicity to Animals
    Special Remarks on        Not available.    
    Chronic Effects on Humans
    Special Remarks on other        Not available.    
    Toxic Effects on Humans

Section 12. Ecological Information
    Ecotoxicity        Not available.    
    BOD5 and COD        Not available.    
    Possibly hazardous short term degradation products are not likely. However, long term degradation products may
    Products of Biodegradation
    The products of degradation are as toxic as the product itself.
    Toxicity of the Products
    of Biodegradation
    Special Remarks on the        Not available.    
    Products of Biodegradation

Section 13. Disposal Considerations
    Waste Disposal

Section 14. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    Not applicable.
    Not applicable.
    Special Provisions for
    DOT (Pictograms)
    Ketamine Hydrochloride

Section 15. Other Regulatory Information and Pictograms
    TSCA 8(b) inventory: No products were found.
    Federal and State
    Proposition 65
    Other Regulations        OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).    
    CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
    Other Classifications        WHMIS (Canada)    
    CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
    DSCL (EEC)        R22- Harmful if swallowed.    
    R36/37/38- Irritating to eyes,
    respiratory system and skin.
    R40- Possible risks of irreversible
    Health Hazard
    HMIS (U.S.A.)        2 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    2 1 Reactivity
    Specific hazard
    Personal Protection
    WHMIS (Canada)
    DSCL (Europe)
    TDG (Canada)
    ADR (Europe)
    Protective Equipment
    Lab coat.
    Vapor respirator. Be sure to use an
    approved/certified respirator or
    equivalent. Wear appropriate respirator
    when ventilation is inadequate.
    Ketamine Hydrochloride


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