ethyl acetate |
|
| CAS No.: | 141-78-6 |
|---|---|
| Synonyms: | |
| Formula: | C4H8O2 |
| Exact Mass: | 88.05240 |
| Molecular Weight: | 88.10510 |
| PSA: | 26.30000 |
| LogP: | 0.56940 |
ethyl acetate 141-78-6 MSDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name : Ethyl acetate
REACH No. : 01-2119475103-46-XXXX
CAS-No. : 141-78-6
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
Eye irritation (Category 2), H319
Specific target organ toxicity - single exposure (Category 3), H336
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
F Highly flammable R11
Xi Irritant R36
R66
R67
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal word Danger
Hazard statement(s)
H225 Highly flammable liquid and vapour.
H319 Causes serious eye irritation.
H336 May cause drowsiness or dizziness.
Precautionary statement(s)
P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard information (EU)
EUH066 Repeated exposure may cause skin dryness or cracking.
Other hazards - none
SECTION 3: Composition/information on ingredients
Substances
Formula : C4H8O2
Molecular Weight : 88,11 g/mol
CAS-No. : 141-78-6
EC-No. : 205-500-4
Registration number : 01-2119475103-46-XXXX
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
Ethyl acetate
CAS-No. 141-78-6 Flam. Liq. 2; Eye Irrit. 2; STOT <= 100 %
EC-No. 205-500-4 SE 3; H225, H319, H336,
Index-No. 607-022-00-5 EUH066
Registration number 01-2119475103-46-XXXX
Hazardous ingredients according to Directive 1999/45/EC
Component Classification Concentration
Ethyl acetate
CAS-No. 141-78-6 F, Xi, R11 - R36 - R66 - R67 <= 100 %
EC-No. 205-500-4
Index-No. 607-022-00-5
Registration number 01-2119475103-46-XXXX
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16
SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available
SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
Use water spray to cool unopened containers.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
form explosive concentrations. Vapours can accumulate in low areas.
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13).
Reference to other sections
For disposal see section 13.
SECTION 7: Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Derived No Effect Level (DNEL)
Application Area Exposure Health effect Value
routes
Workers Inhalation Acute systemic effects 1468 mg/m3
Workers Inhalation Acute local effects 1468 mg/m3
Workers Skin contact Long-term systemic effects 63mg/kg BW/d
Workers Inhalation Long-term systemic effects 734 mg/m3
Workers Inhalation Long-term local effects 734 mg/m3
Consumers Inhalation Acute local effects, Acute systemic 734 mg/m3
effects
Consumers Skin contact Long-term systemic effects 37mg/kg BW/d
Consumers Inhalation Long-term systemic effects 367 mg/m3
Consumers Ingestion Long-term systemic effects 4,5mg/kg BW/d
Consumers Inhalation Long-term local effects 367 mg/m3
Predicted No Effect Concentration (PNEC)
Compartment Value
Soil 0,24 mg/kg
Marine water 0,026 mg/l
Fresh water 0,26 mg/l
Marine sediment 0,125 mg/kg
Fresh water sediment 1,25 mg/kg
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Splash contact
Material: butyl-rubber
Minimum layer thickness: 0,3 mm
Break through time: 113 min
Material tested:Butoject® (KCL 897 / Z677647, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
contact the supplier of the CE approved gloves. This recommendation is advisory only and must
be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
anticipated use by our customers. It should not be construed as offering an approval for any
specific use scenario.
Body Protection
impervious clothing, Flame retardant antistatic protective clothing, The type of protective
equipment must be selected according to the concentration and amount of the dangerous
substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) Appearance Form: clear, liquid
Colour: colourless
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing Melting point/range: -84 °C
point
f) Initial boiling point and 76,5 - 77,5 °C
boiling range
g) Flash point -3,0 °C - closed cup
h) Evapouration rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower Upper explosion limit: 11,5 %(V)
flammability or Lower explosion limit: 2,2 %(V)
explosive limits
k) Vapour pressure 97,3 hPa at 20,0 °C
l) Vapour density no data available
m) Relative density 0,90 g/cm3
n) Water solubility soluble
o) Partition coefficient: n- log Pow: 0,73
octanol/water
p) Auto-ignition 427,0 °C
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
Surface tension 24,0 mN/m at 20,0 °C
SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
Heat, flames and sparks. Extremes of temperature and direct sunlight.
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5
SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
LD50 Oral - rat - 5.620 mg/kg
LC50 Inhalation - mouse - 2 h - 45.000 mg/m3
LD50 Dermal - rabbit - > 18.000 mg/kg
Skin corrosion/irritation
May cause skin irritation and/or dermatitis.
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC,
ACGIH, NTP, or EPA classification.
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
May cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: AH5425000
Inhalation of high concentrations may cause:, Headache, Drowsiness, Dizziness, Vomiting, narcosis,
anemia, Central nervous system depression
Kidney - Irregularities - Based on Human Evidence
SECTION 12: Ecological information
Toxicity
Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - 350,00 - 600,00 mg/l - 96 h
LC50 - Pimephales promelas (fathead minnow) - 220,00 - 250,00 mg/l - 96 h
Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 2.300,00 - 3.090,00 mg/l - 24 h
other aquatic
invertebrates
LC50 - Daphnia magna (Water flea) - 560 mg/l - 48 h
Toxicity to algae EC50 - Algae - 4.300,00 mg/l - 24 h
EC50 - SELENASTRUM - 1.800,00 - 3.200,00 mg/l - 72 h
Persistence and degradability
Biodegradability Result: 79 % - Readily biodegradable.
(OECD Test Guideline 301D)
Bioaccumulative potential
Bioaccumulation -3d
Bioconcentration factor (BCF): 30
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available
SECTION 13: Disposal considerations
Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
company.
Contaminated packaging
Dispose of as unused product.
SECTION 14: Transport information
UN number
ADR/RID: 1173 IMDG: 1173 IATA: 1173
UN proper shipping name
ADR/RID: ETHYL ACETATE
IMDG: ETHYL ACETATE
IATA: Ethyl acetate
Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available
SECTION 15 - REGULATORY INFORMATION
N/A
SECTION 16 - ADDITIONAL INFORMATION
N/A