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SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Ethyl acetate    
    REACH No.        : 01-2119475103-46-XXXX    
    CAS-No.        : 141-78-6    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

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SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Flammable liquids (Category 2), H225
    Eye irritation (Category 2), H319
    Specific target organ toxicity - single exposure (Category 3), H336
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    F Highly flammable        R11    
    Xi Irritant        R36    
    R66
    R67
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Danger    
    Hazard statement(s)
    H225        Highly flammable liquid and vapour.    
    H319        Causes serious eye irritation.    
    H336        May cause drowsiness or dizziness.    
    Precautionary statement(s)
    P210        Keep away from heat/sparks/open flames/hot surfaces. - No smoking.    
    P261        Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.    
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    Supplemental Hazard information (EU)
    EUH066        Repeated exposure may cause skin dryness or cracking.    
  Other hazards - none

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SECTION 3: Composition/information on ingredients
  Substances
    Formula        : C4H8O2    
    Molecular Weight        : 88,11 g/mol    
    CAS-No.        : 141-78-6    
    EC-No.        : 205-500-4    
    Registration number        : 01-2119475103-46-XXXX    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  Ethyl acetate
    CAS-No.        141-78-6        Flam. Liq. 2; Eye Irrit. 2; STOT <= 100 %    
    EC-No.        205-500-4        SE 3; H225, H319, H336,    
    Index-No.        607-022-00-5        EUH066    
    Registration number        01-2119475103-46-XXXX    
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  Ethyl acetate
    CAS-No.        141-78-6        F, Xi, R11 - R36 - R66 - R67        <= 100 %    
    EC-No.        205-500-4    
    Index-No.        607-022-00-5    
    Registration number        01-2119475103-46-XXXX    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

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SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

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SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    Use water spray to cool unopened containers.

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SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
    Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
    form explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13).
  Reference to other sections
    For disposal see section 13.

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SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    charge.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Derived No Effect Level (DNEL)
    Application Area        Exposure        Health effect        Value    
    routes
    Workers        Inhalation        Acute systemic effects        1468 mg/m3    
    Workers        Inhalation        Acute local effects        1468 mg/m3    
    Workers        Skin contact        Long-term systemic effects        63mg/kg BW/d    
    Workers        Inhalation        Long-term systemic effects        734 mg/m3    
    Workers        Inhalation        Long-term local effects        734 mg/m3    
    Consumers        Inhalation        Acute local effects, Acute systemic        734 mg/m3    
    effects
    Consumers        Skin contact        Long-term systemic effects        37mg/kg BW/d    
    Consumers        Inhalation        Long-term systemic effects        367 mg/m3    
    Consumers        Ingestion        Long-term systemic effects        4,5mg/kg BW/d    
    Consumers        Inhalation        Long-term local effects        367 mg/m3    
  Predicted No Effect Concentration (PNEC)
    Compartment        Value    
    Soil        0,24 mg/kg    
    Marine water        0,026 mg/l    
    Fresh water        0,26 mg/l    
    Marine sediment        0,125 mg/kg    
    Fresh water sediment        1,25 mg/kg    
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Splash contact
    Material: butyl-rubber
    Minimum layer thickness: 0,3 mm
    Break through time: 113 min
    Material tested:Butoject® (KCL 897 / Z677647, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    impervious clothing, Flame retardant antistatic protective clothing, The type of protective
    equipment must be selected according to the concentration and amount of the dangerous
    substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

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SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: clear, liquid    
    Colour: colourless
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        Melting point/range: -84 °C    
    point
    f) Initial boiling point and 76,5 - 77,5 °C
    boiling range
    g) Flash point        -3,0 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        Upper explosion limit: 11,5 %(V)    
    flammability or        Lower explosion limit: 2,2 %(V)    
    explosive limits
    k) Vapour pressure        97,3 hPa at 20,0 °C    
    l) Vapour density        no data available    
    m) Relative density        0,90 g/cm3    
    n) Water solubility        soluble    
    o) Partition coefficient: n- log Pow: 0,73
    octanol/water
    p) Auto-ignition        427,0 °C    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    Surface tension        24,0 mN/m at 20,0 °C    

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SECTION 10: Stability and reactivity
  Reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Heat, flames and sparks. Extremes of temperature and direct sunlight.
  Incompatible materials
    Strong oxidizing agents
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

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SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LD50 Oral - rat - 5.620 mg/kg
    LC50 Inhalation - mouse - 2 h - 45.000 mg/m3
    LD50 Dermal - rabbit - > 18.000 mg/kg
  Skin corrosion/irritation
    May cause skin irritation and/or dermatitis.
  Serious eye damage/eye irritation
    no data available
  Respiratory or skin sensitisation
    no data available
  Germ cell mutagenicity
    no data available
  Carcinogenicity
    This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC,
    ACGIH, NTP, or EPA classification.
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
  Reproductive toxicity
    no data available
  Specific target organ toxicity - single exposure
    May cause drowsiness or dizziness.
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Additional Information
    RTECS: AH5425000
    Inhalation of high concentrations may cause:, Headache, Drowsiness, Dizziness, Vomiting, narcosis,
    anemia, Central nervous system depression
    Kidney - Irregularities - Based on Human Evidence

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SECTION 12: Ecological information
  Toxicity
    Toxicity to fish        LC50 - Oncorhynchus mykiss (rainbow trout) - 350,00 - 600,00 mg/l - 96 h    
    LC50 - Pimephales promelas (fathead minnow) - 220,00 - 250,00 mg/l - 96 h
    Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 2.300,00 - 3.090,00 mg/l - 24 h
    other aquatic
    invertebrates
    LC50 - Daphnia magna (Water flea) - 560 mg/l - 48 h
    Toxicity to algae        EC50 - Algae - 4.300,00 mg/l - 24 h    
    EC50 - SELENASTRUM - 1.800,00 - 3.200,00 mg/l - 72 h
  Persistence and degradability
    Biodegradability        Result: 79 % - Readily biodegradable.    
    (OECD Test Guideline 301D)
  Bioaccumulative potential
    Bioaccumulation        -3d    
    Bioconcentration factor (BCF): 30
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    no data available

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SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
    as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
    company.
  Contaminated packaging
    Dispose of as unused product.

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SECTION 14: Transport information
  UN number
    ADR/RID: 1173        IMDG: 1173        IATA: 1173    
  UN proper shipping name
    ADR/RID: ETHYL ACETATE
    IMDG: ETHYL ACETATE
    IATA:        Ethyl acetate    
  Transport hazard class(es)
    ADR/RID: 3        IMDG: 3        IATA: 3    
  Packaging group
    ADR/RID: II        IMDG: II        IATA: II    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available

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SECTION 15 - REGULATORY INFORMATION
N/A

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SECTION 16 - ADDITIONAL INFORMATION
N/A