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lomustine 13010-47-4 MSDS
  Lomustine      Revision number: 5    
  SAFETY DATA SHEET

Section 1. IDENTIFICATION
  Product name:        Lomustine    
    
  Revision number:        5    

Section 2. HAZARDS IDENTIFICATION
  GHS classification
  PHYSICAL HAZARDS        Not classified    
  HEALTH HAZARDS
  Acute toxicity (Oral)        Category 3    
    Category 1B
  Germ cell mutagenicity
  Carcinogenicity        Category 1B    
    Category 1B
  Reproductive toxicity
  Specific target organ toxicity        Liver, Bone marrow    
  - Single exposure [Category 1]
  Specific target organ toxicity        Organs    
  - Single exposure [Category 2]
  Specific target organ toxicity        Bone marrow    
  - Repeated exposure [Category 1]
  Specific target organ toxicity        Liver, Nervous system, Kidney, Lung    
  - Repeated exposure [Category 2]
  ENVIRONMENTAL HAZARDS        Not classified    
  GHS label elements, including precautionary statements
  Pictograms or hazard symbols
    Danger
  Signal word
  Hazard statements        Toxic if swallowed    
    May cause genetic defects
    May cause cancer
    May damage fertility or the unborn child
    Causes damage to organs : Liver Bone marrow
    May cause damage to organs : Organs
    Causes damage to organs through prolonged or repeated
    exposure : Bone marrow
    May cause damage to organs through prolonged or
    repeated exposure : Liver Nervous system Kidney Lung
  Precautionary statements:
  Lomustine

Section 2. HAZARDS IDENTIFICATION
  [Prevention]        Obtain special instructions before use.    
    Do not handle until all safety precautions have been read and understood.
    Do not breathe dust/fume/gas/mist/vapours/spray.
    Do not eat, drink or smoke when using this product.
    Wash hands thoroughly after handling.
    Use personal protective equipment as required.
  [Response]        IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Rinse    
    mouth.
    IF exposed or concerned: Get medical advice/attention.
  [Storage]        Store locked up.    
  [Disposal]        Dispose of contents/container through a waste management company authorized by    
    the local government.

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
    Substance
  Substance/mixture:
  Components:        Lomustine    
    >98.0%(LC)
  Percent:
  CAS Number:        13010-47-4    
  Synonyms:        1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea    
  Chemical Formula:        C9H16ClN3O2    

Section 4. FIRST AID MEASURES
  Inhalation:        Remove victim to fresh air and keep at rest in a position comfortable for breathing.    
    Get medical advice/attention.
  Skin contact:        Remove/Take off immediately all contaminated clothing. Gently wash with plenty of    
    soap and water. Get medical advice/attention.
  Eye contact:        Rinse cautiously with water for several minutes. Remove contact lenses, if present    
    and easy to do. Get medical advice/attention.
  Ingestion:        Immediately call a POISON CENTER or doctor/physician. Rinse mouth.    
  Protection of first-aiders:        A rescuer should wear personal protective equipment, such as rubber gloves and air-    
    tight goggles.

Section 5. FIRE-FIGHTING MEASURES
  Suitable extinguishing        Dry chemical, foam, water spray, carbon dioxide.    
  media:
  Specific hazards arising Explosion risk in case of fire. Fight fire remotely due to the risk of explosion.
  from the chemical:        Take care as it may decompose upon combustion or in high temperatures to    
    generate poisonous fume.
  Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
    method according to the surrounding situation is used. Uninvolved persons should
    evacuate to a safe place. In case of fire in the surroundings: Keep containers cool by
    spraying with water. Eliminate all ignition sources if safe to do so.
  Special protective        When extinguishing fire, be sure to wear personal protective equipment.    
  equipment for firefighters:

Section 6. ACCIDENTAL RELEASE MEASURES
  Personal precautions,        Use extra personal protective equipment (P3 filter respirator for toxic particles). Keep    
  protective equipment and people away from and upwind of spill/leak. Entry to non-involved personnel should
  emergency procedures: be controlled around the leakage area by roping off, etc.
  Environmental precautions: Prevent product from entering drains.
  Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
  containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
  up: appropriate laws and regulations.

Section 7. HANDLING AND STORAGE
  Precautions for safe handling
  Lomustine

Section 7. HANDLING AND STORAGE
  Technical measures:        Handling is performed in a well ventilated place. Wear suitable protective equipment.    
    Be careful not to cause leakage, overflow, or dispersion. Steam should not be
    generated unnecessarily. Keep away from heat/sparks/open flame/hot surfaces. -No
    smoking. Take measures to prevent the build up of electrostatic charge. Use
    explosion-proof equipment. Avoid shock and friction. Wash hands and face before
    breaks and immediately after handling the product.
    Use a closed system if possible. Use a local exhaust if dust or aerosol will be
    generated.
  Advice on safe handling: Avoid all contact!
  Conditions for safe storage, including any
  incompatibilities
  Storage conditions:        Keep container tightly closed. Store in a freezer.    
    Store locked up.
    Be sure not to give the container unexpected impacts, such as falling down or falling
    off.
    Store away from incompatible materials such as oxidizing agents.
    Heat-sensitive
  Packaging material:        Comply with laws.    

Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
  Engineering controls:        Install a closed system or local exhaust. Also install safety shower and eye bath.    
  Personal protective equipment
  Respiratory protection: Dust respirator, self-contained breathing apparatus(SCBA), supplied air respirator,
    etc. Use respirators approved under appropriate government standards and follow
    local and national regulations.
  Hand protection:        Impervious gloves.    
    Safety goggles. A face-shield, if the situation requires.
  Eye protection:
  Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires.

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
  Physical state (20°C):        Solid    
    Crystal- Powder
  Form:
  Colour:        Slightly pale yellow - Yellow    
    No data available
  Odour:
  pH: No data available
  Melting point/freezing point:91°C
  Boiling point/range:        No data available    
  Flash point:        No data available    
  Flammability or explosive
  limits:
  Lower:        No data available    
  Upper:        No data available    
  Relative density:        No data available    
  Solubility(ies):
  [Water]        No data available    
  [Other solvents]        No data available    
  Log Pow:        2.83    

Section 10. STABILITY AND REACTIVITY
  Chemical stability:        Stable under proper conditions.    
  Possibility of hazardous May explosively decompose on heating, shock, friction, etc.
  reactions:
    Heat, Shock, Friction
  Conditions to avoid:
  Incompatible materials: Oxidizing agents, Strong bases
  Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx), Hydrogen chloride
  products:
  Lomustine

Section 11. TOXICOLOGICAL INFORMATION
  Acute Toxicity:        orl-rat LD50:70 mg/kg    
    ipr-rat LD50:50350 ug/kg
    scu-mus LD50:54 mg/kg
  Skin corrosion/irritation: No data available
  Serious eye        No data available    
  damage/irritation:
  Germ cell mutagenicity: mmo-sat 100 ug/plate (+S9)
    mmo-sat 7 ug/plate (-S9)
    cyt-hmn-lym 700 ug/L
    dnd-mus-ivn 48 mg/kg
  Carcinogenicity:        orl-rat TDLo:50 mg/kg    
    skn-mus TDLo:276 mg/kg/23W-I
  IARC =        Group 2A (Probably carcinogenic to humans)    
  NTP =        b (Reasonably anticipated to be carcinogens)    
    No data available
  Reproductive toxicity:
  RTECS Number:        YS4900000    

Section 12. ECOLOGICAL INFORMATION
  Ecotoxicity:
  Fish:        No data available    
  Crustacea:        No data available    
  Algae:        No data available    
  Persistence / degradability: No data available
  Bioaccumulative        34    
  potential(BCF):
  Mobility in soil
    2.83
  Log Pow:
  Soil adsorption (Koc):        200    
    1.8 x 10-5
  Henry's Law
  constant(PaM3/mol):

Section 13. DISPOSAL CONSIDERATIONS
    Recycle to process, if possible. Consult your local regional authorities and an expert of disposal. You may be able
    to dissolve or mix material with a combustible solvent and little by little burn in a chemical incinerator equipped with
    an afterburner and scrubber system. If a large amount of the substance is burned at a time, an explosion may
    occur. Observe all federal, state and local regulations when disposing of the substance.

Section 14. TRANSPORT INFORMATION
  Hazards Class:        6.1: Toxic substance.    
  UN-No:        2811    
  Proper shipping name:        Toxic solid, organic, n.o.s.    
  Packing group:        III    

Section 15. REGULATORY INFORMATION
  Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
  and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
    loading and unloading were prescribed.
  Lomustine


SECTION 16 - ADDITIONAL INFORMATION
N/A

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