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hydroquinone 123-31-9 MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Hydroquinone    
    Index-No.        : 604-005-00-4    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
    CAS-No.        : 123-31-9    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Acute toxicity, Oral (Category 4), H302
    Serious eye damage (Category 1), H318
    Skin sensitisation (Category 1), H317
    Germ cell mutagenicity (Category 2), H341
    Carcinogenicity (Category 2), H351
    Acute aquatic toxicity (Category 1), H400
    Chronic aquatic toxicity (Category 1), H410
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    Xn Harmful        R22    
    Xi Irritant        R41    
    N Dangerous for the        R50    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Signal word        Danger    
    Hazard statement(s)
    H302        Harmful if swallowed.    
    H317        May cause an allergic skin reaction.    
    H318        Causes serious eye damage.    
    H341        Suspected of causing genetic defects.    
    H351        Suspected of causing cancer.    
    H410        Very toxic to aquatic life with long lasting effects.    
    Precautionary statement(s)
    P273        Avoid release to the environment.    
    P280        Wear protective gloves/ eye protection/ face protection.    
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    P501        Dispose of contents/ container to an approved waste disposal plant.    
    Supplemental Hazard        none    
  Other hazards - none

SECTION 3: Composition/information on ingredients
    Synonyms        : 1,4-Benzenediol    
    Formula        : C6H6O2    
    Molecular Weight        : 110,11 g/mol    
    CAS-No.        : 123-31-9    
    EC-No.        : 204-617-8    
    Index-No.        : 604-005-00-4    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
    CAS-No.        123-31-9        Acute Tox. 4; Eye Dam. 1;        <= 100 %    
    EC-No.        204-617-8        Skin Sens. 1; Muta. 2; Carc. 2;    
    Index-No.        604-005-00-4        Aquatic Acute 1; Aquatic    
    Chronic 1; H302, H317, H318,
    H341, H351, H410
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
    CAS-No.        123-31-9        Xn, N, Carc.Cat.3, Mut.Cat.3, <= 100 %    
    EC-No.        204-617-8        R22 - R40 - R41 - R43 - R68 -    
    Index-No.        604-005-00-4        R50    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    no data available

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
    adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
    environment must be avoided.
  Methods and materials for containment and cleaning up
    Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
    containers for disposal.
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
    Provide appropriate exhaust ventilation at places where dust is formed.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
    Air and light sensitive.
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Full contact
    Material: Nitrile rubber
    Minimum layer thickness: 0,11 mm
    Break through time: 480 min
    Material tested:Dermatril® (KCL 740 / Z677272, Size M)
    Splash contact
    Material: Nitrile rubber
    Minimum layer thickness: 0,11 mm
    Break through time: 480 min
    Material tested:Dermatril® (KCL 740 / Z677272, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    Complete suit protecting against chemicals, The type of protective equipment must be selected
    according to the concentration and amount of the dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face particle
    respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering
    controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use
    respirators and components tested and approved under appropriate government standards such
    as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
    the environment must be avoided.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: crystalline    
    Colour: colourless
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        3,7 at 70 g/l    
    e) Melting point/freezing        Melting point/range: 172 - 175 °C - lit.    
    f) Initial boiling point and 285 °C - lit.
    boiling range
    g) Flash point        165 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        no data available    
    flammability or
    explosive limits
    k) Vapour pressure        1 hPa at 132 °C    
    l) Vapour density        3,80 - (Air = 1.0)    
    m) Relative density        1,332 g/cm3    
    n) Water solubility        50 g/l    
    o) Partition coefficient: n- log Pow: 0,59
    p) Auto-ignition        515,56 °C    
    q) Decomposition        no data available    
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    Bulk density        550 - 650 kg/m3    
    Solubility in other        Methanol    
    solvents        Diethylether    
    Relative vapour density 3,80 - (Air = 1.0)

SECTION 10: Stability and reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Air Light.
  Incompatible materials
    Strong bases, Strong oxidizing agents
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LD50 Oral - rat - 367,3 mg/kg
    (OECD Test Guideline 401)
    LD50 Dermal - rabbit - > 2.000 mg/kg
    (OECD Test Guideline 402)
  Skin corrosion/irritation
    no data available
  Serious eye damage/eye irritation
    Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
  Respiratory or skin sensitisation
    in vivo assay - mouse
    Result: May cause sensitisation by skin contact.
    May cause allergic skin reaction.
    (OECD Test Guideline 429)
  Germ cell mutagenicity
    Laboratory experiments have shown mutagenic effects.
    In vitro tests showed mutagenic effects
    DNA repair
    rat - Liver cells
    Result: negative
    Mutagenicity (micronucleus test)
    Result: positive
    This product is or contains a component that has been reported to be possibly carcinogenic based on its
    IARC, ACGIH, NTP, or EPA classification.
    Limited evidence of carcinogenicity in animal studies
    IARC:        3 - Group 3: Not classifiable as to its carcinogenicity to humans (Hydroquinone)    
  Reproductive toxicity
    no data available
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Additional Information
    RTECS: MX3500000
    Absorption into the body leads to the formation of methemoglobin which in sufficient concentration causes
    cyanosis. Onset may be delayed 2 to 4 hours or longer.
    Liver - Irregularities - Based on Human Evidence

SECTION 12: Ecological information
    Toxicity to fish        LC50 - Oncorhynchus mykiss (rainbow trout) - 0,04 - 0,1 mg/l - 96,0 h    
    Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 0,13 mg/l - 48 h
    other aquatic
    Toxicity to algae        EC50 - Pseudokirchneriella subcapitata (green algae) - 0,335 mg/l - 72 h    
  Persistence and degradability
    Biodegradability        Biotic/Aerobic - Exposure time 14 d    
    Result: 86 % - Readily biodegradable.
  Bioaccumulative potential
    Bioaccumulation        Leuciscus idus (Golden orfe) - 3 d    
    - 50 µg/l
    Bioconcentration factor (BCF): 40
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    Very toxic to aquatic life with long lasting effects.

SECTION 13: Disposal considerations
  Waste treatment methods
    Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
    with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 3077        IMDG: 3077        IATA: 3077    
  UN proper shipping name
    IATA:        Environmentally hazardous substance, solid, n.o.s. (Hydroquinone)    
  Transport hazard class(es)
    ADR/RID: 9        IMDG: 9        IATA: 9    
  Packaging group
    ADR/RID: III        IMDG: III        IATA: III    
  Environmental hazards
    ADR/RID: yes        IMDG Marine pollutant: yes        IATA: yes    
  Special precautions for user
  Further information
    EHS-Mark required (ADR, IMDG code 2.10.3) for single packagings and combination
    packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids.

SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
    no data available
  Chemical Safety Assessment
    For this product a chemical safety assessment was not carried out

SECTION 16: Other information
  Full text of H-Statements referred to under sections 2 and 3.
    Acute Tox.        Acute toxicity    
    Aquatic Acute        Acute aquatic toxicity    
    Aquatic Chronic        Chronic aquatic toxicity    
    Carc.        Carcinogenicity    
    Eye Dam.        Serious eye damage    
    H302        Harmful if swallowed.    
    H317        May cause an allergic skin reaction.    
    H318        Causes serious eye damage.    
    H341        Suspected of causing genetic defects.    
    H351        Suspected of causing cancer.    
    H400        Very toxic to aquatic life.    
    H410        Very toxic to aquatic life with long lasting effects.    
  Full text of R-phrases referred to under sections 2 and 3
    N Dangerous for the environment
    Xn Harmful
    R22 Harmful if swallowed.
    R40 Limited evidence of a carcinogenic effect.
    R41 Risk of serious damage to eyes.
    R43 May cause sensitisation by skin contact.
    R50 Very toxic to aquatic organisms.
    R68 Possible risk of irreversible effects.
  Further information
    Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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