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4-Fluorophenyl isocyanate 1195-45-5 MSDS
Name: 4-Fluorophenyl isocyanate 99% Material Safety Data Sheet
Synonym: p-Fluorophenyl isocyanate
CAS: 1195-45-5
Section 1 - Chemical Product   MSDS Name:4-Fluorophenyl isocyanate 99% Material Safety Data Sheet
Synonym:p-Fluorophenyl isocyanate

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
1195-45-5 4-Fluorophenyl isocyanate 99 214-799-0
Hazard Symbols: T+
Risk Phrases: 26 36/37/38 42

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Very toxic by inhalation. Irritating to eyes, respiratory system and skin. May cause sensitization by inhalation.Moisture sensitive.
Potential Health Effects
Eye:
Vapors cause eye irritation. Lachrymator (substance which increases the flow of tears). May cause severe eye irritation and possible injury.
Skin:
Causes skin irritation. Organic isocyanates can cause local irritation and allergic reactions. Isocyanates, in general, can cause skin discoloration (staining) and hardening of the skin after repeated exposures.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed.
Inhalation:
May be fatal if inhaled. Causes respiratory tract irritation. May cause allergic respiratory reaction. At high concentrations, isocyanates affect mucous membranes of the respiratory tract and may lead to fatal pulmonary edema.
Chronic:
Chronic overexposure to isocyanates has been reported to cause lung damage, including decreased lung fuction, which may be permanent.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with soap and plenty of water. Remove contaminated clothing and shoes. Get medical aid if symptoms occur. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
POISON material. If inhaled, get medical aid immediately. Remove victim to fresh air. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Flammable liquid and vapor. Fire or excessive heat may result in violent rupture of the container due to bulk polymerization. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use carbon dioxide or dry chemical.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not get water inside containers. Evacuate unnecessary personnel.
Approach spill from upwind.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep away from heat, sparks and flame. Do not breathe vapor or mist. Inform laundry personnel of contaminant's hazards. Isocyanates react with water to form CO2 gas. This gas can cause sealed containers to expand and possibly rupture. Use only with adequate ventilation or respiratory protection. Never work alone with this chemical.
Storage:
Refrigerator/flammables. Store in tightly closed containers to prevent moisture contamination. Do not reseal if contamination is suspected.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits CAS# 1195-45-5: Personal Protective Equipment Eyes: Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Color: clear light yellow to yellow orange
Odor: irritating odor
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 68 deg C
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 60 deg C ( 140.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Hydrolysis.
Specific Gravity/Density: 1.206 g/cm3
Molecular Formula: C7H4FNO
Molecular Weight: 137.11

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures. May polymerize.
Conditions to Avoid:
Ignition sources, moisture, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, strong bases, amines, alcohols, water.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride gas.
Hazardous Polymerization: May occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 1195-45-5 unlisted.
LD50/LC50:
Not available.
Data for similar chemical, 4-chlorophenyl isocyanate, CAS 104-12-1: Carcinogenicity:
4-Fluorophenyl isocyanate - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: ISOCYANATES, TOXIC, FLAMMABLE, N.O.S.*
Hazard Class: 6.1 (3)
UN Number: 3080
Packing Group: II
IMO
Shipping Name: ISOCYANATES, TOXIC, FLAMMABLE, N.O.S.
Hazard Class: 6.1 (3)
UN Number: 3080
Packing Group: II
RID/ADR
Shipping Name: ISOCYANATES, TOXIC, FLAMMABLE, N.O.S.
Hazard Class: 6.1
UN Number: 3080
Packing group: II

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+
Risk Phrases:
R 26 Very toxic by inhalation.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
R 42 May cause sensitization by inhalation.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28A After contact with skin, wash immediately with
plenty of water.
S 38 In case of insufficient ventilation, wear
suitable respiratory equipment.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 1195-45-5: No information available.
Canada
CAS# 1195-45-5 is listed on Canada's DSL List.
CAS# 1195-45-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1195-45-5 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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