pyridine
CAS No.: 110-86-1
Synonyms:
Formula: C5H5N
Exact Mass: 79.04220
Molecular Weight: 79.09990
PSA: 12.89000
LogP: 1.08160
pyridine 110-86-1 MSDS
  Pyridine [Sequencing Solvent]      Revision number: 6    
  SAFETY DATA SHEET

Section 1. IDENTIFICATION
  Product name:        Pyridine [Sequencing Solvent]    
    
  Revision number:        6    

Section 2. HAZARDS IDENTIFICATION
  GHS classification
  PHYSICAL HAZARDS
    Category 2
  Flammable liquids
  HEALTH HAZARDS
    Category 4
  Acute toxicity (Oral)
  Acute toxicity (Dermal)        Category 3    
    Category 4
  Acute toxicity (Inhalation)
  Skin corrosion/irritation        Category 1B    
    Category 1
  Serious eye damage/eye irritation
  Carcinogenicity        Category 2    
    Category 2
  Reproductive toxicity
  Specific target organ toxicity        Respiratory system, Nervous system    
  - Single exposure [Category 1]
  Specific target organ toxicity        Narcotic effects    
  - Single exposure [Category 3]
  Specific target organ toxicity        Liver, Nervous system, Kidney    
  - Repeated exposure [Category 1]
  Specific target organ toxicity        Blood system    
  - Repeated exposure [Category 2]
  ENVIRONMENTAL HAZARDS
  Acute aquatic hazard        Category 1    
  GHS label elements, including precautionary statements
  Pictograms or hazard symbols
  Signal word        Danger    
  Hazard statements        Highly flammable liquid and vapour    
    Harmful if swallowed or if inhaled
    Toxic in contact with skin
    Causes severe skin burns and eye damage
    Suspected of causing cancer
    Suspected of damaging fertility or the unborn child
    Causes damage to organs : Respiratory system Nervous
    system
  Pyridine [Sequencing Solvent]

Section 2. HAZARDS IDENTIFICATION
    Causes damage to organs through prolonged or repeated
    exposure : Liver Nervous system Kidney
    May cause damage to organs through prolonged or
    repeated exposure : Blood system
    May cause drowsiness or dizziness
    Very toxic to aquatic life
  Precautionary statements:
  [Prevention]        Obtain special instructions before use.    
    Do not handle until all safety precautions have been read and understood.
    Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
    Keep container tightly closed.
    Use explosion-proof electrical/ventilating/lighting equipment. Take precautionary
    measures against ignition by the static discharge and the spark.
    Do not breathe dust/fume/gas/mist/vapours/spray.
    Use only outdoors or in a well-ventilated area.
    Avoid release to the environment.
    Do not eat, drink or smoke when using this product.
    Wash hands thoroughly after handling.
    Wear protective gloves and eye/face protection.
  [Response]        IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for    
    breathing. Call a POISON CENTER or doctor/physician if you feel unwell.
    IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
    IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
    if present and easy to do. Continue rinsing.
    IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse
    skin with water/shower.
    Remove/Take off immediately all contaminated clothing.
    Wash contaminated clothing before reuse.
    Immediately call a POISON CENTER or doctor/physician.
    Collect spillage.
  [Storage]        Store in a well-ventilated place. Keep container tightly closed.    
    Store locked up.
  [Disposal]        Dispose of contents/container through a waste management company authorized by    
    the local government.

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
  Substance/mixture:        Substance    
    Pyridine [Sequencing Solvent]
  Components:
  Percent:        >99.0%(GC)    
    110-86-1
  CAS Number:
  Chemical Formula:        C5H5N    

Section 4. FIRST AID MEASURES
  Inhalation:        Remove victim to fresh air and keep at rest in a position comfortable for breathing.    
    Immediately call a POISON CENTER or doctor/physician.
  Skin contact:        Remove/Take off immediately all contaminated clothing. Gently wash with plenty of    
    soap and water. Immediately call a POISON CENTER or doctor/physician.
  Eye contact:        Rinse cautiously with water for several minutes. Remove contact lenses, if present    
    and easy to do. Continue rinsing.Immediately call a POISON CENTER or
    doctor/physician.
    Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT
  Ingestion:
    induce vomiting.
  Most important        Cough, Dizziness, Headache, Nausea, Shortness of breath, Unconsciousness,    
  symptoms/effects, acute        Abdominal pain, Diarrhoea, Vomiting, Weakness, Redness, Burning sensation, Pain    
  and delayed:
  Pyridine [Sequencing Solvent]
  Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-
    tight goggles.
  Indication of immediate Depending on the degree of exposure, periodic medical examination is indicated.
  medical attantion and
  special treatment needed, if
  necessary:

Section 5. FIRE-FIGHTING MEASURES
  Suitable extinguishing        Dry chemical, foam, water in large amounts, carbon dioxide.    
  media:
  Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
  from the chemical:        generate poisonous fume.    
  Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
    method according to the surrounding situation is used. Uninvolved persons should
    evacuate to a safe place. In case of fire in the surroundings: Keep containers cool by
    spraying with water. Eliminate all ignition sources if safe to do so.
  Special protective        When extinguishing fire, be sure to wear personal protective equipment.    
  equipment for firefighters:

Section 6. ACCIDENTAL RELEASE MEASURES
  Personal precautions,        Use extra personal protective equipment (self-contained breathing apparatus). Keep    
  protective equipment and people away from and upwind of spill/leak. Ensure adequate ventilation. Entry to non-
  emergency procedures: involved personnel should be controlled around the leakage area by roping off, etc.
  Environmental precautions: Be careful not to let it flow into rivers, etc., since adverse effects on the environment
    are concerned.
  Methods and materials for Absorb spilled material in dry sand or inert absorbent before recovering it into an
  containment and cleaning airtight container. In case of large amount of spillage, contain a spill by bunding.
  up: Adhered or collected material should be promptly disposed of, in accordance with
    appropriate laws and regulations.
  Prevention of secondary Remove all sources of ignition. Fire-extinguishing devices should be prepared in
  hazards:        case of a fire. Use spark-proof tools and explosion-proof equipment.    

Section 7. HANDLING AND STORAGE
  Precautions for safe handling
  Technical measures:        Handling is performed in a well ventilated place. Wear suitable protective equipment.    
    Prevent generation of vapour or mist. Keep away from heat/sparks/open flame/hot
    surfaces. -No smoking. Take measures to prevent the build up of electrostatic
    charge. Use explosion-proof equipment. Wash hands and face thoroughly after
    handling.
    Use a closed system if possible. Use a ventilation, local exhaust if vapour or aerosol
    will be generated.
  Advice on safe handling: Avoid all contact!
  Conditions for safe storage, including any
  incompatibilities
    Keep container tightly closed. Store in a cool, dark and well-ventilated place.
  Storage conditions:
    Store locked up.
    Store away from incompatible materials such as oxidizing agents.
  Packaging material:        Comply with laws.    

Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
  Engineering controls:        Install a closed system or local exhaust. Also install safety shower and eye bath.    
  Exposure limits:
  ACGIH TLV(TWA):        5 ppm    
    5 ppm
  OSHA PEL(TWA):
  Personal protective equipment
  Respiratory protection:        Half or full facepiece respirator, self-contained breathing apparatus(SCBA), supplied    
    air respirator, etc. Use respirators approved under appropriate government standards
    and follow local and national regulations.
  Pyridine [Sequencing Solvent]

Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
  Hand protection:        Impervious gloves.    
  Eye protection:        Safety goggles. A face-shield, if the situation requires.    
  Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires.

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
  Physical state (20°C):        Liquid    
    Clear
  Form:
  Colour:        Colorless    
  Odour:        Unpleasant    
  pH: 8.5 (0.2 mol H2O soln.)
  Melting point/freezing point:-42°C
  Boiling point/range:        115°C    
  Flash point:        16°C    
  Flammability or explosive
  limits:
  Lower:        1.8%    
  Upper:        12.4%    
  Vapour pressure:        2.0kPa/20°C    
  Vapour density:        2.73    
  Relative density:        0.98    
  Solubility(ies):
  [Water]        Miscible    
  [Other solvents]
  Miscible:        Ether, Alcohols, Benzene, Petroleum ether, Many organic solvents    
  Log Pow:        0.65    
  Autoignition temperature:        482°C    

Section 10. STABILITY AND REACTIVITY
  Chemical stability:        Stable under proper conditions.    
  Possibility of hazardous No special reactivity has been reported.
  reactions:
    Spark, Open flame, Static discharge
  Conditions to avoid:
  Incompatible materials: Oxidizing agents, Strong acids
  Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx), Hydrogen cyanide
  products:

Section 11. TOXICOLOGICAL INFORMATION
    ihl-rat LC50:28500 mg/m3/1H
  Acute Toxicity:
    ipr-rat LC50:866 mg/kg
    orl-rat LD50:891 mg/kg
    skn-rbt LD50:1121 mg/kg
  Skin corrosion/irritation: skn-rbt 500 mg/24H MLD
    No data available
  Serious eye
  damage/irritation:
  Germ cell mutagenicity: mmo-sat 6 mmol/L/2H (-S9)
  Carcinogenicity:        orl-mus TDLo:11025mg/kg/105W-C    
    orl-rat TDLo:7350 mg/kg/105W-C
  IARC =        Group 3 (Not classifiable as carcinogenic to humans)    
    No data available
  NTP =
  Reproductive toxicity:        No data available    
    UR8400000
  RTECS Number:

Section 12. ECOLOGICAL INFORMATION
  Ecotoxicity:
  Fish:        96h LC50:>100 mg/L (Oryzias latipes)    
  Crustacea:        48h EC50:180 mg/L (Daphnia magna)    
  Algae:        72h EC50:0.041 mg/L (Selenastrum capricornutum)    
  Pyridine [Sequencing Solvent]

Section 12. ECOLOGICAL INFORMATION
  Persistence / degradability: 92 - 94% (by BOD), 100% (by HPLC), 98% (by TOC)
  Bioaccumulative        88    
  potential(BCF):
  Mobility in soil
  Log Pow:        0.65    
    50
  Soil adsorption (Koc):
  Henry's Law        1.1    
  constant(PaM3/mol):

Section 13. DISPOSAL CONSIDERATIONS
    Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
    incinerator equipped with an afterburner and scrubber system but exert extra care in igniting as this material is
    highly flammable. Observe all federal, state and local regulations when disposing of the substance

Section 14. TRANSPORT INFORMATION
  Hazards Class:        3: Flammable liquid.    
    1282
  UN-No:
  Proper shipping name:        Pyridine    
    II
  Packing group:
  Marine pollutant        Y    

Section 15. REGULATORY INFORMATION
  Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
  and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
    loading and unloading were prescribed.
  The list of a dangerous chemical(2002)/CN-No.: 32104


SECTION 16 - ADDITIONAL INFORMATION
N/A

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