Acetic anhydride
CAS No.: 108-24-7
Synonyms:
Formula: C4H6O3
Exact Mass: 102.03200
Molecular Weight: 102.08900
PSA: 43.37000
LogP: 0.09600
Acetic anhydride 108-24-7 MSDS
Name: Acetic anhydride, p.a. Material Safety Data Sheet
Synonym: Acetic oxide; Acetyl oxide; Ethanoic anhydride; Acetic acid anhydride.
CAS: 108-24-7
Section 1 - Chemical Product MSDS Name: Acetic anhydride, p.a. Material Safety Data Sheet
Synonym: Acetic oxide; Acetyl oxide; Ethanoic anhydride; Acetic acid anhydride.
SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
108-24-7 Acetic anhydride ca 100 203-564-8
Hazard Symbols: C
Risk Phrases: 10 20/22 34
SECTION 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Flammable. Harmful by inhalation and if swallowed. Causes burns.Corrosive.Moisture sensitive. Potential Health Effects
Eye:
Eye damage may be delayed. Contact with liquid is corrosive to the eyes and causes severe burns. When substance becomes wet or comes in contact with moisture of the mucous membranes, it will cause irritation. May cause chemical conjunctivitis and corneal damage.
Skin:
Contact with skin causes irritation and possible burns, especially if the skin is wet or moist. Prolonged skin contact may be painless with reddening of the skin followed be a white appearance of the skin. Skin burns may be delayed. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May be harmful if swallowed. Ingestion of large amounts may cause CNS depression. May cause systemic effects.
Inhalation:
Harmful if inhaled. Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. Causes chemical burns to the respiratory tract. May cause lung damage. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause systemic effects. May cause burning sensation in the chest.
Chronic:
Effects may be delayed.
SECTION 4 - FIRST AID MEASURES
Eyes:
Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Discard contaminated clothing in a manner which limits further exposure. If water-reactive products are embedded in the skin, no water should be applied. The embedded products should be covered with a light oil.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:


SECTION 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. Wear appropriate protective clothing to prevent contact with skin and eyes. Wear a self-contained breathing apparatus (SCBA) to prevent contact with thermal decomposition products. Containers may explode in the heat of a fire. Flammable liquid and vapor. May ignite or explode on contact with steam or moist air.
Extinguishing Media:
Use dry sand or earth to smother fire. If water is the only media available, use in flooding amounts. DO NOT USE WATER! Do NOT use straight streams of water. Contact professional fire-fighters immediately. Cool containers with flooding quantities of water until well after fire is out.
SECTION 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not expose spill to water. Spill may be carefully neutralized with lime (calcium oxide, CaO). Cover with material such as dry soda ash or calcium carbonate and place into a closed container for disposal. A vapor suppressing foam may be used to reduce vapors.
SECTION 7 - HANDLING and STORAGE
Handling:
Remove contaminated clothing and wash before reuse. Do not allow water to get into the container because of violent reaction. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep away from heat, sparks and flame. Use with adequate ventilation. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Do not store in direct sunlight. Keep container closed when not in use. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Flammables-area.
SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels. Personal Protective Equipment
Eyes:
Wear chemical goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless
Odor: strong odor - pungent odor - acetic odor
pH: Not available.
Vapor Pressure: 3.9 mm Hg @68F
Viscosity: Not available.
Boiling Point: 137 deg C
Freezing/Melting Point: Not available.
Autoignition Temperature: 630 deg F ( 332.22 deg C)
Flash Point: 126 deg F ( 52.22 deg C)
Explosion Limits, lower: 2.9%
Explosion Limits, upper: 10.3%
Decomposition Temperature:
Solubility in water: Decomposes.
Specific Gravity/Density: 1.0820g/cm3
Molecular Formula: C4H6O3
Molecular Weight: 102.09
SECTION 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable. However, may decompose if exposed to moist air or water. Substance is readily hydrolyzed. Reacts with water to form corresponding acid.
Conditions to Avoid:
Ignition sources, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Alcohols, moisture, bases, strong oxidizing agents, strong reducing agents, metal powders.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
SECTION 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 108-24-7: AK1925000
LD50/LC50:
CAS# 108-24-7: Inhalation, rat: LC50 = 1000 ppm/4H; Oral, rat: LD50 = 1780 mg/kg; Skin, rabbit: LD50 = 4 mL/kg.
Carcinogenicity:
Acetic anhydride - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
SECTION 12 - ECOLOGICAL INFORMATION Other For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND EXPOSURE DATA."
SECTION 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations.
SECTION 14 - TRANSPORT INFORMATION IATA
Shipping Name: ACETIC ANHYDRIDE
Hazard Class: 8
UN Number: 1715
Packing Group: II IMO
Shipping Name: ACETIC ANHYDRIDE
Hazard Class: 8
UN Number: 1715
Packing Group: II RID/ADR
Shipping Name: ACETIC ANHYDRIDE
Hazard Class: 8
UN Number: 1715
Packing group: II
USA RQ:CAS# 108-24-7: 5000 lb final RQ; 2270 kg final RQ
SECTION 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 10 Flammable. R 20/22 Harmful by inhalation and if swallowed. R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 108-24-7: 1 United Kingdom Occupational Exposure Limits CAS# 108-24-7: OES-United Kingdom, TWA 0.5 ppm TWA; 2.5 mg/m3 TWA CAS# 108-24-7: OES-United Kingdom, STEL 2 ppm STEL; 10 mg/m3 STEL United Kingdom Maximum Exposure Limits Canada CAS# 108-24-7 is listed on Canada's DSL List. CAS# 108-24-7 is listed on Canada's Ingredient Disclosure List. Exposure Limits US FEDERAL TSCA CAS# 108-24-7 is listed on the TSCA inventory.
SECTION 16 - ADDITIONAL INFORMATION
MSDS Creation Date: 9/02/1997 Revision #6 Date: 3/18/2003 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages.

SECTION 16 - ADDITIONAL INFORMATION
N/A

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